Improved ecological development model for lower Yellow River floodplain,China

In this study,a model for the development of the wide floodplain in the lower Yellow River Basin,in China was developed.This model includes flood control schemes using grading criteria,enables sediment deposition in partitioned zones,and allows free exchange between channel runoff and sediment.The wide floodplain located between the main channel and levees is divided into three typical regions:the tender,low,and high floodplains.Different ecological models should be applied when these floodplains are constructed.This paper describes the associated research ideas and methodology,and clarifies several key issues,including sediment prediction and regulation,land planning,land use,and a multi-dimensional framework of safeguard measures for industries on the lower Yellow River floodplain.A refined ecological development model is proposed for the lower Yellow River floodplain,and future work on ecological and sustainable development of the lower floodplain is suggested.To establish a comprehensive system integrating runoff and sediment resource regulation in the Yellow River Basin,future work should focus on runoff and sediment exchange mechanisms in the wandering lower reaches.Furthermore,it is necessary to improve theories on floodplain planning and ecological construction,and these theories should be integrated with the research findings on land development across the lower Yellow River floodplain.©2020 Hohai University.Production and hosting by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).

Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer

AIM To explore the effects of omeprazole on chemoradiotherapy efficacy and tumor recurrence in rectal cancer. METHODS The medical data of 125 rectal cancer patients who received the same neoadjuvant chemoradiotherapy(CRT) followed by surgery were retrospectively collected. Patients who received omeprazole(OME) orally at a dose of 20 mg at least once daily for six days and/or intravenously at 40 mg a day were recognized as eligible OME users(EOU). Otherwise, patients were regarded as non-eligible OME users(non-EOU).Moreover, a preferred OME dose cut-off of 200 mg on tumor recurrence was obtained by receiver operating characteristic(ROC) curves. Patients were divided into two groups: the effective OME group(EOG, OME ≥ 200 mg) and the non-effective OME group(non-EOG, OME < 200 mg). RESULTS The good response rate of CRT efficacy(50.8%) in EOU was significantly increased compared with nonEOU(30.6%)(P = 0.02). The recurrence rate in the EOG was 10.3%, which was significantly lower compared with 31.3% in non-EOG(P = 0.025). The good response rate of CRT efficacy in EOG was 55.2%, which was obviously higher compared with 36.5% in non-EOG, with a significant difference(P = 0.072). Multivariate Cox analysis demonstrated that OME(nonEOG and EOG) was an independent and significant impact factor for DFS(P = 0.048, HR = 0.30, 95%CI: 0.09-0.99).CONCLUSION When applied as an adjuvant drug in cancer treatment for relieving common side effects of chemotherapy, omeprazole has a synergetic effect in improving CRT efficacy and decreasing rectal cancer recurrence.

Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer

AIM: To investigate the clinical significance of methylmethanesulfonate sensitivity 19(MMS19) expression in esophageal squamous cell carcinoma(ESCC).METHODS: Between June 2008 and May 2013, specimens from 103 patients who underwent endoscopic biopsy for the diagnosis of ESCC at the endoscopy center of Sun Yat-Sen University Cancer Center were collected; 52 matched-normal esophageal squamous epithelium samples were biopsied as controls.MMS19 protein expression was measured by immunohistochemistry.Of the 103 cases of ESCC, 49 received radical surgery following neoadjuvant chemoradiotherapy consisting of concurrent radiation in a total dose of 40 Gy and two cycles of chemotherapy with vinorelbine and cisplatin.Relationships between MMS19 expression, clinicopathologic characteristics and chemoradiotherapy response were analyzed.RESULTS: The MMS19 protein could be detected in both the cytoplasm and nucleus of most specimens.High cytoplasmic expression of MMS19 was detected in 63.1% of ESCC samples, whereas high nuclearexpression of MMS19 was found in 35.0%.High cytoplasmic MMS19 expression was associated with regional lymph node metastases(OR = 11.3, 95%CI: 2.3-54.7; P < 0.001) and distant metastases(OR = 13.1, 95%CI: 1.7-103.0; P = 0.002).Furthermore, high cytoplasmic MMS19 expression was associated with a response of ESCC to chemoradiotherapy(OR = 11.5, 95%CI: 3.0-44.5; P < 0.001), with a high cytoplasmic MMS19 expression rates in 79.3% and 25.0% of patients from the good chemoradiotherapy response group and poor response group, respectively.Nuclear MMS19 expression did not show any significant association with clinicopathologic characteristics or chemoradiotherapy response in ESCC.CONCLUSION: The results of our preliminary study suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in ESCC.

Base level changes based on Basin Filling Modelling:a case study from the Paleocene Lishui Sag,East China Sea Basin

Estimation of base level changes in geological records is an important topic for petroleum geologists.Taking the Paleocene Upper Lingfeng Member of Lishui Sag as an example,this paper conducted a base level reconstruction based on Basin Filling Modelling(BFM).The reconstruction was processed on the ground of a previously interpreted seismic stratigraphic framework with several assumptions and simplification.The BFM is implemented with a nonlinear diffusion equation solver written in R coding that excels in shallow marine stratigraphic simulation.The modeled results fit the original stratigraphy very well.The BFM is a powerful tool for reconstructing the base level,and is an effective way to check the reasonableness of previous interpretations.Although simulation solutions may not be unique,the BFM still provides us a chance to gain some insights into the mechanism and dynamic details of the stratigraphy of sedimentary basins.

Additive manufacturing and foundry innovation

Additive manufacturing is expected to transform and upgrade the traditional foundry industry to realize the integrated manufacturing and rapid and low-cost development of high-performance components with complex shapes.The additive manufacturing technology commonly applied in casting mold preparation(fusible molds,sand molds/cores and ceramic cores)mainly includes selective laser sintering(SLS)and binder injection three-dimensional printing(3DP).In this work,the research status of SLS/3DP-casting processes on material preparation,equipment development,process optimization,simulation and application cases in aerospace,automotive and other fields were elaborated.Finally,the developing trends of the additive manufacturing technology in the future of foundry field are introduced,including multi-material sand molds(metal core included),ceramic core-shell integration and die-casting dies with conformal cooling runners.

Identification of waterflooded zones and the impact of waterflooding on reservoir properties of the Funing Formation in the Subei Basin,China

This paper describes the identification of waterflooded zones and the impact of waterflooding on reservoir properties of sandstones of the Funing Formation at the Gao 6 Fault-block of the Gaoji Oilfield,in the Subei Basin,east China.This work presents a new approach based on a back-propagation neural network using well log data to train the network,and then generating a cross-plot plate to identify waterflooded zones.A neural network was designed and trained,and the results show that the new method is better than traditional methods.For a comparative study,two representative wells at the Gao 6 Fault-block were chosen for analysis:one from a waterflooded zone,and the other from a zone without waterflooding.Results from this analysis were used to develop a better understanding of the impact of waterflooding on reservoir properties.A range of changes are shown to have taken place in the waterflooded zone,including changes in microscopic pore structure,fluids,and minerals.

The rudist buildup depositional model,reservoir architecture and development strategy of the cretaceous Sarvak formation of Southwest Iran

This paper studies the lithofacies,sedimentary facies,depositional models and reservoir architecture of the rudist-bearing Sar-3 zone of Cretaceous Sarvak in the Southwest of Iran by utilizing coring,thin section,XRD data of five coring wells and 3D seismic data.Research results include the following:According to lithofacies features and their association,the rudist-mound and tidal flat are the main microfacies in the Sar-3 depositional time.By investigating the regional tectonic setting and seismic interpretation,a depositional model was built for the Sar-3 zone,which highlights four key points:1)The distribution of the rudist-buildup is controlled by the paleo-high.2)The build-up outside of the wide colonize stage but reached the wave-base level in a short time by regression and formation uplift,and was destroyed by the high energy current,then forming the moundy allochthonous deposition after being dispersed and redeposited.3)The tidal flat develops widely in the upper Sar-3,and the deposition thickness depends on the paleo-structure.The tidal channel develops in the valley and fringe of the Paleo-structure.4)The exposure within the leaching effect by the meteoric water of the top of Sar-3 is the main controlling factor of the reservoir vertical architecture.The Sar-3 zone featured as the dualistic architecture consists of two regions:the lower is the rudist reef limestone reservoir and the upper is the tidal condense limestone interlayer.The thickness of each is controlled by the paleo-structure.The Paleo-high zone is the preferential development zone.Based on reservoir characteristics of the different zones,a targeted development strategy has been proposed.Keeping the trajectory in the middle of the oillayer in the paleo-high,and in the paleo-low,make the trajectory crossing the oil-zone and then keep it in the lower.

Advances in surface markers of liver cancer stem cell

Liver cancer stem cells(LCSCs),a small subpopulation that constitutes liver cancer heterogeneity,play a vital role in cancer initiation,invasion,recurrence,metastasis,and resistance to chemo-radiotherapy.It is believed that therapies targeting LCSCs can improve the efficacy of conventional chemotherapy and radiotherapy by completely eliminating tumors while preventing recurrence.Therefore,during last decades,numerous surface markers for LCSCs have been identified and characterized in many subtypes of liver cancer,especially in hepatocellular carcinoma(HCC).These well-recognized surface markers significantly promote the therapeutic efficacy that identifies,targets and destroys LCSCs.Meanwhile,there have been intensive studies that aim to investigate the molecular mechanism of how stemness contributes to liver cancer relapse,recurrence and resistance.However,liver cancer stemness seems to be regulated by a hierarchical organization and crosstalk of a wide variety of signaling pathways.Using individual or few LCSC surface markers may not be able to completely reveal the intrinsic stemness hierarchy.From an integrated perspective,understanding of recent advances in LCSC surface markers remains important and urgent.In this review,we concentrate on demonstrating the indispensable roles of LCSC surface markers in identification and characterization of multiple cancer stages including initiation,invasion,metastasis,resistance and highlighting the cutting-edge therapeutic strategies against cancer stem cells in HCC.

Cyclooxygenase-2 gene -1195G/A genotype is associatedwith the risk of HBV-induced HCC: A case-control study in HanChinese people

This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma(HCC)with hepatitis B virus(HBV)infection.We conducted a population-based,case-control study enrolling 630 Han Chinese people in Hubei province.Subjects included primary HCC patients with HBV infection(n=210),chronic hepatitis B cases(n=210)and healthy Han Chinese(n=210).-1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and sequencing analysis.We found-1195A allele carriers had a higher risk of HCC with HBV infection(OR,0.72;95%CI,0.548–0.946).The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.

A new method of preparing NdB_(6)ultra-fine powders

Combustion synthesis method was used to prepare NdB_(6)ultra-fine powders with B_(2)O_(3),Nd_(2)O_(3)and Mg powders as the raw materials.The basic thermody-namic data of NdB_(6) were estimated.The standard forma-tion heat of NdB_(6) is-357.48 kJ·mol^(-1).The values of the heat capacity and the standard entropy are 96.87 and 86.60 J·K^(-1)·mol^(-1),respectively.The adiabatic tempera-ture of the reaction is 2726 K,which is higher than the thermodynamic criterion of 1800 K.This indicates that the combustion synthesis reaction of the B_(2)O_(3)-Nd_(2)O_(3)-Mg system could spontaneously take place by itself to generate NdB_(6).The NdB_(6) powders were characterized by X-ray diffractometer(XRD),scanning electron microscopy(SEM)and differential scanning calorimetry-thermo-gravimetry(DSC-TG).The results indicate that the com-bustion products consist of NdB_(6),MgO,and a few Mg_(3)B_(2)O_(6)and Nd_(2)B_(2)O_(6).The leached products consist of single NdB_(6) phase,and its purity is 98.6 wt%.When the sample preparation pressure is 20 MPa,the average parti-cle size of NdB_(6) powders is less than 500 nm.The antioxidant ability of NdB_(6) is very strong,which is oxi-dized step by step.The apparent activation energies of the oxidation reactions are 986.14 and 313.83 kJ·mol^(-1),respectively.In addition,the reaction orders are 4.10 and 3.75,respectively.