Professor Heng Li(李恒,March 9,1929-January 12,2023)was a legendary plant taxonomist and phytogeographer at the Kunming Institute of Botany,Chinese Academy of Sciences(Fig.1).She made important contributions to our un...Professor Heng Li(李恒,March 9,1929-January 12,2023)was a legendary plant taxonomist and phytogeographer at the Kunming Institute of Botany,Chinese Academy of Sciences(Fig.1).She made important contributions to our understanding of China's flora,including the biodiversity and biogeography of Dulong Valley and the Gaoligong Mountains,as well as the vegetation of plateau lakes and wetlands in Southwest China.Professor Heng Li received her Bachelor's degree in Russian from Beijing Foreign Studies University in 1956 and immediately joined the Institute of Geography(now Institute of Geographic Sciences and Natural Resources Research),Chinese Academy of Sciences,as a Russian translator.In 1961,Prof.展开更多
Objective:To explore the protective effect of Linggui Zhugan Decoction(LGZGD)medicated serum on myocardial fibrosis induced by transforming growth factor-β1(TGF-β1).Methods:Using enzyme digestion method,combined wit...Objective:To explore the protective effect of Linggui Zhugan Decoction(LGZGD)medicated serum on myocardial fibrosis induced by transforming growth factor-β1(TGF-β1).Methods:Using enzyme digestion method,combined with differential adherence to isolate and culture Sprague-Dawley(SD)suckling mouse Cardiac fibroblasys(CFB)in vitro.Divided into:blank group,blank rat serum group,model group,and LGZGD medicated serum group(5%、10%、20%).Except for blank group and blank rat serum group,they were stimulated with 5 ng/ml TGF-β1 for 12 hours,and then then intervene with LGZGD medicated serum(5%、10%、20%)and continue to culture for 24 hours.Use immunofluorescence and Western blot(WB)to detect the expression ofα-smooth muscle actin(α-SMA),Enzyme-linked immunosorbent assay(ELISA)and WB to detect type Ⅰ collagen(Collagen Ⅰ),type Ⅰ collagen(Collagen Ⅲ)and fibronectin(FN)expression.Results:Compared with the blank group,the expressions of Collagen Ⅰ,Collagen Ⅲ,α-SMA and FN in the model group were significantly increased(P<0.01);Compared with the model group,the expressions of Collagen Ⅰ and Collagen Ⅲ in each concentration group of the experiment were significantly reduced(P<0.01);the expression ofα-SMA and FN were significantly reduced(P<0.01).Conclusions:LGZGD has an inhibitory effect on collagen synthesis and the expression ofα-SMA and FN,indicating that the anti-fibrosis effect of LGZGD is related to it.展开更多
Objective:To explore the characteristics of ZHANG Zhongjing's medication for constipation by analyzing the prescriptions of treatise on Shanghan Lun and Jingui Yaolue.Methods:the formulations that met the inclusio...Objective:To explore the characteristics of ZHANG Zhongjing's medication for constipation by analyzing the prescriptions of treatise on Shanghan Lun and Jingui Yaolue.Methods:the formulations that met the inclusion criteria were selected to establish a database,and the regularity of ZHANG Zhongjing's medication for constipation was analyzed by the methods of frequency,association rules and clustering.Results:In this study,11 prescriptions and 24 medicines were included.High-frequency use of drugs rhubarb,licorice,CortexMagnoliae Officinalis,fructus aurantii immaturus,mirabilis,ginger,jujube,white atractylodes rhizome,cassia twig,Chinese herbaceous peony.A total of 17 association rules(11 rules for 2 drugs and 6 rules for 3 drugs)were obtained by mining,including"Rhubarb+Mirabilite","fructus aurantii immaturus+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis+fructus aurantii immaturus",and so on,and 7 groups of drug pair association group and 2 groups of multi-flavor drug association group were obtained.Network link analysis shows that there are 7 groups of strong link compatibility.Medium link compatibility 46 groups.Cluster analysis obtained 14 groups,including 8 single-taste drug groups,3 drug-pair polymerization groups and 3 multi-taste drug polymerization groups.Conclusions:ZHANG Zhongjing is not only good at using purgative medicine in treating constipation treating constipation,but also pays attention to invigorating qi and activating blood circulation,resolving the surface and regulating dampness,soothing the liver and regulating qi.展开更多
Cotton is not only an important source of textile fibre and edible oil, but also a valuable source of high-quality protein and fodder, because 45%00～500%00 of the cotton seed powder is protein.However, the seeds ... Cotton is not only an important source of textile fibre and edible oil, but also a valuable source of high-quality protein and fodder, because 45%00～500%00 of the cotton seed powder is protein.However, the seeds of cultivated cotton usually contain a special polyphenol compound called gossypol, which is poisonous and hinders the utilization of the seeds. Therefore breeding new cotton species with no or low gossypol in seeds with gossypol in plant body is drawing more and more attention from both in China and abroad.
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文摘Professor Heng Li(李恒,March 9,1929-January 12,2023)was a legendary plant taxonomist and phytogeographer at the Kunming Institute of Botany,Chinese Academy of Sciences(Fig.1).She made important contributions to our understanding of China's flora,including the biodiversity and biogeography of Dulong Valley and the Gaoligong Mountains,as well as the vegetation of plateau lakes and wetlands in Southwest China.Professor Heng Li received her Bachelor's degree in Russian from Beijing Foreign Studies University in 1956 and immediately joined the Institute of Geography(now Institute of Geographic Sciences and Natural Resources Research),Chinese Academy of Sciences,as a Russian translator.In 1961,Prof.
基金National natural science foundation of China(No.81973844)。
文摘Objective:To explore the protective effect of Linggui Zhugan Decoction(LGZGD)medicated serum on myocardial fibrosis induced by transforming growth factor-β1(TGF-β1).Methods:Using enzyme digestion method,combined with differential adherence to isolate and culture Sprague-Dawley(SD)suckling mouse Cardiac fibroblasys(CFB)in vitro.Divided into:blank group,blank rat serum group,model group,and LGZGD medicated serum group(5%、10%、20%).Except for blank group and blank rat serum group,they were stimulated with 5 ng/ml TGF-β1 for 12 hours,and then then intervene with LGZGD medicated serum(5%、10%、20%)and continue to culture for 24 hours.Use immunofluorescence and Western blot(WB)to detect the expression ofα-smooth muscle actin(α-SMA),Enzyme-linked immunosorbent assay(ELISA)and WB to detect type Ⅰ collagen(Collagen Ⅰ),type Ⅰ collagen(Collagen Ⅲ)and fibronectin(FN)expression.Results:Compared with the blank group,the expressions of Collagen Ⅰ,Collagen Ⅲ,α-SMA and FN in the model group were significantly increased(P<0.01);Compared with the model group,the expressions of Collagen Ⅰ and Collagen Ⅲ in each concentration group of the experiment were significantly reduced(P<0.01);the expression ofα-SMA and FN were significantly reduced(P<0.01).Conclusions:LGZGD has an inhibitory effect on collagen synthesis and the expression ofα-SMA and FN,indicating that the anti-fibrosis effect of LGZGD is related to it.
基金National Natural Science Foundation of China(No.81173171,81573864,81373533).
文摘Objective:To explore the characteristics of ZHANG Zhongjing's medication for constipation by analyzing the prescriptions of treatise on Shanghan Lun and Jingui Yaolue.Methods:the formulations that met the inclusion criteria were selected to establish a database,and the regularity of ZHANG Zhongjing's medication for constipation was analyzed by the methods of frequency,association rules and clustering.Results:In this study,11 prescriptions and 24 medicines were included.High-frequency use of drugs rhubarb,licorice,CortexMagnoliae Officinalis,fructus aurantii immaturus,mirabilis,ginger,jujube,white atractylodes rhizome,cassia twig,Chinese herbaceous peony.A total of 17 association rules(11 rules for 2 drugs and 6 rules for 3 drugs)were obtained by mining,including"Rhubarb+Mirabilite","fructus aurantii immaturus+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis","Rhubarb+Cortex Magnoliae Officinalis+fructus aurantii immaturus",and so on,and 7 groups of drug pair association group and 2 groups of multi-flavor drug association group were obtained.Network link analysis shows that there are 7 groups of strong link compatibility.Medium link compatibility 46 groups.Cluster analysis obtained 14 groups,including 8 single-taste drug groups,3 drug-pair polymerization groups and 3 multi-taste drug polymerization groups.Conclusions:ZHANG Zhongjing is not only good at using purgative medicine in treating constipation treating constipation,but also pays attention to invigorating qi and activating blood circulation,resolving the surface and regulating dampness,soothing the liver and regulating qi.
文摘 Cotton is not only an important source of textile fibre and edible oil, but also a valuable source of high-quality protein and fodder, because 45%00～500%00 of the cotton seed powder is protein.However, the seeds of cultivated cotton usually contain a special polyphenol compound called gossypol, which is poisonous and hinders the utilization of the seeds. Therefore breeding new cotton species with no or low gossypol in seeds with gossypol in plant body is drawing more and more attention from both in China and abroad.
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