Major infrastructures such as levee, dam, bridge, road, etc. have a significant meaning in that they are the means to support ordinary social and industrial activities and also protect human and physical assets at the...Major infrastructures such as levee, dam, bridge, road, etc. have a significant meaning in that they are the means to support ordinary social and industrial activities and also protect human and physical assets at the occurrence of disaster. Especially, integrated risk management of SOC facilities provides the policy maker in charge of SOC facility safety and related disaster prevention with a reasonable means of decision making and ultimately contributes to improving the safety of the applicable SOC facility. Furthermore, a variety of issues raised in the Sewol ferry disaster that occurred recently in Korea, such as, a proper response method and the relevant Golden time decision making at the occurrence of disaster, rapid grasping and reporting the situation on disaster sites, management and mobilization of resources for rescue and recover, loss of integrated control tower function, etc., might occur as well in facility disaster management. As the method of solving such issues adequately, this study suggests a strategy of new disaster response and management system. The analyses of Hazus-MH (FEMA) and DIMSuS (Purdue University) were comprehensively conducted, and based on the results required functions of new disaster response system of major infrastructure and its development directions were suggested.展开更多
Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue therapy.The ionically rich glass component of PAC encourages bioactive interaction via.the release of essential ions.However,PAC bioactivit...Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue therapy.The ionically rich glass component of PAC encourages bioactive interaction via.the release of essential ions.However,PAC bioactivity is restricted owing to(i)structurally inherent cationic network formers and(ii)surface bacterial biofilm formation.These two factors cause a deficiency in ion release,further complicated by secondary infections and premature therapeutic failure.Here,a multivalent zwitterionic network modifier(mZM)is presented for upregulation of ionic exchange and bioactivity enhancement.By introducing a non-zero charged mZM into PACs,an increase in the proportion of non-bridging oxygen occurs.The network modification promotes ion channel formation,causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite(ca.74%).Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the mZM.Furthermore,divalent cationic interaction results in bacterial biofilm reduction(ca.68%)while also influencing a shift in the biofilm species composition,which favors commensal growth.Therefore,PAC modification with mZM offers a promising solution for upregulation of bioactivity,even aiding in customization by targeting site-specific regenerative therapy in future applications.展开更多
文摘Major infrastructures such as levee, dam, bridge, road, etc. have a significant meaning in that they are the means to support ordinary social and industrial activities and also protect human and physical assets at the occurrence of disaster. Especially, integrated risk management of SOC facilities provides the policy maker in charge of SOC facility safety and related disaster prevention with a reasonable means of decision making and ultimately contributes to improving the safety of the applicable SOC facility. Furthermore, a variety of issues raised in the Sewol ferry disaster that occurred recently in Korea, such as, a proper response method and the relevant Golden time decision making at the occurrence of disaster, rapid grasping and reporting the situation on disaster sites, management and mobilization of resources for rescue and recover, loss of integrated control tower function, etc., might occur as well in facility disaster management. As the method of solving such issues adequately, this study suggests a strategy of new disaster response and management system. The analyses of Hazus-MH (FEMA) and DIMSuS (Purdue University) were comprehensively conducted, and based on the results required functions of new disaster response system of major infrastructure and its development directions were suggested.
基金supported by the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health and Welfare,the Ministry of Food and Drug Safety)(Project Number:KMDF_PR_20200901_0067-01)by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2021R1A2C2091260)by faculty research grant of Yonsei University College of Dentistry(6-2021-0037).
文摘Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue therapy.The ionically rich glass component of PAC encourages bioactive interaction via.the release of essential ions.However,PAC bioactivity is restricted owing to(i)structurally inherent cationic network formers and(ii)surface bacterial biofilm formation.These two factors cause a deficiency in ion release,further complicated by secondary infections and premature therapeutic failure.Here,a multivalent zwitterionic network modifier(mZM)is presented for upregulation of ionic exchange and bioactivity enhancement.By introducing a non-zero charged mZM into PACs,an increase in the proportion of non-bridging oxygen occurs.The network modification promotes ion channel formation,causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite(ca.74%).Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the mZM.Furthermore,divalent cationic interaction results in bacterial biofilm reduction(ca.68%)while also influencing a shift in the biofilm species composition,which favors commensal growth.Therefore,PAC modification with mZM offers a promising solution for upregulation of bioactivity,even aiding in customization by targeting site-specific regenerative therapy in future applications.