Osteoporosis is caused by unbalanced bone reconstruction processes which leads to areduction in bone mineral density and changes in bone microstructure,resulting in increased fracture risk.Osteoclasts are the only bon...Osteoporosis is caused by unbalanced bone reconstruction processes which leads to areduction in bone mineral density and changes in bone microstructure,resulting in increased fracture risk.Osteoclasts are the only bone resorption cells in the body of human being,and are closely related to the pathogenesis of osteoporosis.In recent years,there have been more in-depth studies on osteoclasts and bone resorption.The pathogenesis of osteoporosis has always been an important research topic for many medical specialists.Cytokines,as important humoral factors that regulate bone metabolism,play an important role in osteoporosis,especially in the formation,differentiation,and apoptosis of osteoclasts.On the basis of referring to the related studies at home and abroad,this paper analyzes the action mechanism of cytokines such as interleukin-1,interleukin-6,nuclear factor KB ligand receptor activator(RANKL)and tumor necrosis factor(TNF)family members on osteoclasts,and clarifies the relationship between cytokines and osteoporosis,which provides a new angle for the prophylaxis and therapy of osteoporosis.展开更多
文摘Osteoporosis is caused by unbalanced bone reconstruction processes which leads to areduction in bone mineral density and changes in bone microstructure,resulting in increased fracture risk.Osteoclasts are the only bone resorption cells in the body of human being,and are closely related to the pathogenesis of osteoporosis.In recent years,there have been more in-depth studies on osteoclasts and bone resorption.The pathogenesis of osteoporosis has always been an important research topic for many medical specialists.Cytokines,as important humoral factors that regulate bone metabolism,play an important role in osteoporosis,especially in the formation,differentiation,and apoptosis of osteoclasts.On the basis of referring to the related studies at home and abroad,this paper analyzes the action mechanism of cytokines such as interleukin-1,interleukin-6,nuclear factor KB ligand receptor activator(RANKL)and tumor necrosis factor(TNF)family members on osteoclasts,and clarifies the relationship between cytokines and osteoporosis,which provides a new angle for the prophylaxis and therapy of osteoporosis.
