The first enantioselective synthesis of axially chiral styrene-type allylamines was achieved through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols.This protocol ...The first enantioselective synthesis of axially chiral styrene-type allylamines was achieved through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols.This protocol features a broad substrate scope,good enantioselectivities(up to 90%ee)and mild reaction conditions,thus providing a new entry to the challenging atropisomeric acyclic styrene scaffolds.展开更多
基金We thank the National Natural Science Foundation of China(No.21602097 and 21601006)for financial support.Financial support from Heze University and Anhui University of Chinese Medicine is also gratefully acknowledged.
文摘The first enantioselective synthesis of axially chiral styrene-type allylamines was achieved through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols.This protocol features a broad substrate scope,good enantioselectivities(up to 90%ee)and mild reaction conditions,thus providing a new entry to the challenging atropisomeric acyclic styrene scaffolds.
