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血清LncRNA PVT1、LncRNA H19表达与前列腺癌患者术后复发转移的关系 被引量:3
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作者 陈金玉 张平 +2 位作者 孙颖昕 潘敏杰 周珊 《中国现代医学杂志》 CAS 北大核心 2021年第22期44-49,共6页
目的探讨血清长链非编码RNA(LncRNA)浆细胞瘤可变易位基因1(PVT1)、LncRNA H19表达与前列腺癌患者术后复发转移的关系。方法选取2016年5月—2018年5月南京医科大学附属常州市第二人民医院收治的169例前列腺癌患者作为前列腺癌组,统计患... 目的探讨血清长链非编码RNA(LncRNA)浆细胞瘤可变易位基因1(PVT1)、LncRNA H19表达与前列腺癌患者术后复发转移的关系。方法选取2016年5月—2018年5月南京医科大学附属常州市第二人民医院收治的169例前列腺癌患者作为前列腺癌组,统计患者术后3年复发转移率。另选取同期该院健康体检者74例作为对照组。qRT-PCR检测血清LncRNA PVT1、LncRNA H19表达。多因素Cox回归分析前列腺癌患者术后复发转移影响因素。ROC曲线分析血清LncRNA PVT1、LncRNA H19表达对前列腺癌患者术后复发转移的预测价值。结果前列腺癌组血清LncRNA PVT1、LncRNA H19相对表达量高于对照组(P<0.05)。复发转移组与未复发转移组TNM分期、Gleason评分、PSA、LncRNA PVT1、LncRNA H19表达比较,差异有统计学意义(P<0.05),两组年龄、病理类型、肿瘤直径、分化程度比较差异无统计学意义(P>0.05)。多因素Cox回归分析结果显示,TNM分期Ⅲ期[O^R=3.722(95 CI:1.416,7.784),P<0.05]、Gleason评分≥7分[O^R=4.626(95%CI:1.670,9.815),P<0.05]、LncRNA PVT1[O^R=1.982(95 CI%:1.521,2.584),P<0.05]、LncRNA H19[O^R=1.868(95%CI:1.327,2.630),P<0.05]是前列腺癌患者术后复发转移的独立危险因素。联合血清LncRNA PVT1、LncRNA H19表达预测AUC大于单独预测。结论前列腺癌患者血清LncRNA PVT1、LncRNA H19高表达,为术后复发转移的独立危险因素,可作为前列腺癌患者术后复发转移预测指标。 展开更多
关键词 前列腺癌 术后复发转移 长链非编码RNA
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Neck pain and absence of cranial nerve symptom are clues of cervical myelopathy mimicking stroke:Two case reports
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作者 Li-Li Zhou Shi-Guo Zhu +6 位作者 Yuan Fang Shi-Shi Huang Jie-Fan Huang Ze-Di Hu jin-yu chen Xiong Zhang Jian-Yong Wang 《World Journal of Clinical Cases》 SCIE 2022年第32期11835-11844,共10页
BACKGROUND Cervical myelopathy is a potential stroke imitator,for which intravenous thrombolysis would be catastrophic.CASE SUMMARY We herein present two cases of cervical myelopathy.The first patient presented with a... BACKGROUND Cervical myelopathy is a potential stroke imitator,for which intravenous thrombolysis would be catastrophic.CASE SUMMARY We herein present two cases of cervical myelopathy.The first patient presented with acute onset of right hemiparesis and urinary incontinence,and the second patient presented with sudden-onset right leg monoplegia.The initial diagnoses for both of them were ischemic stroke.However,both of them lacked cranial nerve symptom and suffered neck pain at the beginning of onset.Their cervical spinal cord lesions were finally confirmed by cervical computed tomography.A literature review showed that neck pain and absence of cranial nerve symptom are clues of cervical myelopathy.CONCLUSION The current report and the review remind us to pay more attention to these two clues in suspected stroke patients,especially those within the thrombolytic time window. 展开更多
关键词 Cervical cord Spinal cord diseases STROKE Neck pain Cranial nerves Hematoma epidural spinal Neoplasm metastasis Case report
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Three-dimensional atom localization via spontaneous emission in a four-level atom
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作者 Fei Song jin-yu chen +1 位作者 Zhi-Ping Wang Ben-Li Yu 《Frontiers of physics》 SCIE CSCD 2018年第5期175-181,共7页
We investigate high-precision three-dimensional (3D) atom localization in a coherently-driven, four- level atomic system via spontaneous emission. Space-dependent atom-field interactions allow atomic position inform... We investigate high-precision three-dimensional (3D) atom localization in a coherently-driven, four- level atomic system via spontaneous emission. Space-dependent atom-field interactions allow atomic position information to be obtained by measuring parameters, atoms within a certain range can be spontaneous emission. By properly varying system localized with nearly a probability of 100% and a maximal resolution of -0.04λ. This scheme may be useful for the high-precision measurement of the center-of-mass wave functions of moving atoms and in atom nanolithography. 展开更多
关键词 atom localization spontaneous emission dressed-state picture
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