Effects of general anesthesia on coagulation function, stress response and other correlation factors in patients undergoing abdominal operation

Objective:To study the effects of general anesthesia on coagulation function, stress response and other correlation factors in patients undergoing abdominal operation.Methods: To select 94 cases of patients undergoing abdominal operation in our hospital from February 2016 to April 2018, divided into the control group and observation group, 47 cases in each group. On the basis of the same pre-processing, the patients in the control group were given epidural anesthesia, and the patients in the observation group received general anesthesia, to detect and compare the coagulation function, stress response and other correlation factors.Results:At T1, the levels of coagulation function (D-Dimer, APTT, PT, PLT), stress response (COR, ACTH, CRP, ET-1) and other correlation factors (IL-23, IL-32, M-CSF, PRL, PCT, NO, TNF-α) between the two groups had no statistical difference (P>0.05). At T2 and T3, the levels of coagulation function(D-Dimer), stress response (COR, ACTH, CRP, ET-1) and other correlation factors (IL-23, IL-32, M-CSF, PRL, PCT, NO, TNF-α) between the two groups had statistical difference (P<0.05).Conclusion:Application of general anesthesia in abdominal endoscopic operation, there was no significant change in coagulation function compared with epidural anesthesia, it could maintain stable coagulation function, but it had a better stabilizing effect on stress response index and other correlation factor such as IL-23, IL-32, M-CSF, PRL, PCT, NO and TNF-α, it was worthy of further clinical study.