Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we ration...Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe (Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1)) with AIE properties for cancer-targeted imaging. The biotinylated probe 1 can be actively uptaken by the biotin receptor-overexpressing cancer cells, and then “smartly” self-assemble into nanoparticles inside cells and turn the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.展开更多
The honeycomb phononic crystal displays good performance in reducing vibration, especially at low frequency, but there are few corresponding experiments involving this kind of phononic crystal and the influence of geo...The honeycomb phononic crystal displays good performance in reducing vibration, especially at low frequency, but there are few corresponding experiments involving this kind of phononic crystal and the influence of geometric parameters on the bandgap is unclear. We design a honeycomb phononic crystal, which is assembled by using a chemigum plate and a steel column, calculate the bandgaps of the phononic crystal, and analyze the vibration modes. In the experiment, we attach a same-sized rubber plate and a phononic crystal to a steel plate separately in order to compare their vibration reduction performances. We use 8×8 unit cells as a complete phononic crystal plate to imitate an infinite period structure and choose a string suspension arrangement to support the experiment. The results show that the honeycomb phononic crystal can reduce the vibrating plate magnitude by up to 60 dB in a frequency range of 600 Hz–900 Hz, while the rubber plate can reduce only about 20 dB. In addition, we study the effect of the thickness of plate and the height and the radius of the column in order to choose the most superior parameters to achieve low frequency and wide bandgap.展开更多
Dented n anospheres show promisi ng potential in drug delivery,nano motors,etc.However,it is still challe nging to prepare them by homopolymer self-assembly because of the strict structural requirements of the homopol...Dented n anospheres show promisi ng potential in drug delivery,nano motors,etc.However,it is still challe nging to prepare them by homopolymer self-assembly because of the strict structural requirements of the homopolymer.Herein,we propose a strategy for preparing dented nano spheres from homopolymers by co-assembly with a short peptide.They were co-assembled from poly(2-hydroxy-3-((4-(ethoxycarbonyl)phenyl)amino)propyl methacrylate)(PHBzoMA59)and(S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpro-panamido)-3-phenyIpropanoic acid(Fmoc-FF-OH).PHBzoMA homopolymers can only self-assemble into nanospheres without dent,and the addition of a short peptide in troduced hydroge n bondi ng and complementary π-π stacki ng interactions led to the final dented nano sphere morphology.The weight fracti ons of the short peptide can be adjusted to regulate the final morphology.It was con firmed that the radius of curvature of the dent on the surface was related to the organic bubble inside the protospheres prepared at critical aggregation concentration(CAC).The orga nic bubble can be adjusted by altering the kind of orga nic solve nt and solution pH,which allowed control over the dented nano sphere dimension.The use of differe nt orga nic solve nts with various polarities allows adjustment of the interfacial tension,and hence the denting degree.This degree can also be controlled by manipulating the solution pH to(de)protonate the short peptide and homopolymer.Furthermore,the versatility of this method was highlighted by using a differe nt homopolymer and the applicability of the resulting den ted nanospheres was demonstrated by decoration with gold nanoparticles.Overall,this study provided important insights and a new simple strategy to prepare den ted n anospheres in a con trolled fashion.展开更多
基金supported by Anhui Scientific and Technological Project(No.1704a0802164)the Natural Science Foundation of the Anhui Higher Education Institutions of China(No.KJ2018A0192)
文摘Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe (Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1)) with AIE properties for cancer-targeted imaging. The biotinylated probe 1 can be actively uptaken by the biotin receptor-overexpressing cancer cells, and then “smartly” self-assemble into nanoparticles inside cells and turn the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.
基金Project supported by the Fundamental Research Funds for the Central Universities,China(Grant No.NS2017003)
文摘The honeycomb phononic crystal displays good performance in reducing vibration, especially at low frequency, but there are few corresponding experiments involving this kind of phononic crystal and the influence of geometric parameters on the bandgap is unclear. We design a honeycomb phononic crystal, which is assembled by using a chemigum plate and a steel column, calculate the bandgaps of the phononic crystal, and analyze the vibration modes. In the experiment, we attach a same-sized rubber plate and a phononic crystal to a steel plate separately in order to compare their vibration reduction performances. We use 8×8 unit cells as a complete phononic crystal plate to imitate an infinite period structure and choose a string suspension arrangement to support the experiment. The results show that the honeycomb phononic crystal can reduce the vibrating plate magnitude by up to 60 dB in a frequency range of 600 Hz–900 Hz, while the rubber plate can reduce only about 20 dB. In addition, we study the effect of the thickness of plate and the height and the radius of the column in order to choose the most superior parameters to achieve low frequency and wide bandgap.
基金by the National Science Fund for Distinguished Young Scholars,NSFC(No.21925505)Z.F.is supported by the National Natural Science Foundation of China(Nos.51803152,22075212)+2 种基金the program for professor of special appointment(Eastern Scholar)at Shanghai institutions of higher learning and Natural Science Foundation of Shanghai(19ZR1478800)Y.Z.is supported by the National Natural Science Foundation of China(No.51903190)and Shanghai Pujiang Program(No.19PJ140960)EJ.C.is supported by the China Postdoctoral Science Foundation(No.2020M671197).
文摘Dented n anospheres show promisi ng potential in drug delivery,nano motors,etc.However,it is still challe nging to prepare them by homopolymer self-assembly because of the strict structural requirements of the homopolymer.Herein,we propose a strategy for preparing dented nano spheres from homopolymers by co-assembly with a short peptide.They were co-assembled from poly(2-hydroxy-3-((4-(ethoxycarbonyl)phenyl)amino)propyl methacrylate)(PHBzoMA59)and(S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpro-panamido)-3-phenyIpropanoic acid(Fmoc-FF-OH).PHBzoMA homopolymers can only self-assemble into nanospheres without dent,and the addition of a short peptide in troduced hydroge n bondi ng and complementary π-π stacki ng interactions led to the final dented nano sphere morphology.The weight fracti ons of the short peptide can be adjusted to regulate the final morphology.It was con firmed that the radius of curvature of the dent on the surface was related to the organic bubble inside the protospheres prepared at critical aggregation concentration(CAC).The orga nic bubble can be adjusted by altering the kind of orga nic solve nt and solution pH,which allowed control over the dented nano sphere dimension.The use of differe nt orga nic solve nts with various polarities allows adjustment of the interfacial tension,and hence the denting degree.This degree can also be controlled by manipulating the solution pH to(de)protonate the short peptide and homopolymer.Furthermore,the versatility of this method was highlighted by using a differe nt homopolymer and the applicability of the resulting den ted nanospheres was demonstrated by decoration with gold nanoparticles.Overall,this study provided important insights and a new simple strategy to prepare den ted n anospheres in a con trolled fashion.
