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膀胱癌组织黑色素瘤抗原-A3的表达及其对核因子KappaB信号通路的影响 被引量:3
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作者 周高峰 黄智红 +6 位作者 吕磊 向威 孙莹 朱金燕 袁敬东 章传华 吴维 《中国现代医学杂志》 CAS 2018年第21期36-41,共6页
目的探讨膀胱癌组织中黑色素瘤抗原-A3(MAGE-A3)的表达变化及其对核因子Kappa B(NF-κB)信号通路相关炎症因子表达的影响。方法依照纳入与排除标准,收集该院膀胱癌患者120例。实时荧光定量PCR(q RT-PCR)和Western blot检测膀胱癌组织中M... 目的探讨膀胱癌组织中黑色素瘤抗原-A3(MAGE-A3)的表达变化及其对核因子Kappa B(NF-κB)信号通路相关炎症因子表达的影响。方法依照纳入与排除标准,收集该院膀胱癌患者120例。实时荧光定量PCR(q RT-PCR)和Western blot检测膀胱癌组织中MAGE-A3 m RNA和蛋白的表达变化;ELISA检测膀胱癌组织中NF-κB信号通路相关炎症因子如肿瘤坏死因子α(TNF-α)和白介素1β(IL-1β)的表达变化;分析MAGE-A3阳性率和炎症因子含量与年龄、性别、肿瘤组织类型及肿瘤分期等的关系;培养膀胱癌细胞系T24,采用小干扰RNA(si RNA)敲减MAGE-A3的表达后,检测NF-κB P65磷酸化水平变化及TNF-α和IL-1β的表达变化。结果膀胱癌组织中MAGE-A3 m RNA、蛋白及炎症因子的表达水平高于正常膀胱组织,差异有统计学意义(P<0.01);MAGE-A3阳性率及患者肿瘤组织中炎症因子含量与一般临床资料无相关,而与膀胱癌分期呈正相关;si RNA敲减MAGE-A3的表达后,NF-κB p65磷酸化水平及TNF-α和IL-1β的表达水平均降低,差异有统计学意义(均P<0.01)。结论 MAGE-A3可能通过NF-κB信号通路调控膀胱癌细胞炎症状态,促进膀胱癌的发生发展。 展开更多
关键词 膀胱癌 MAGE-A3 NF-ΚB信号通路 p65磷酸化 炎症因子
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High-order Soliton Matrix for the Third-order Flow Equation of the Gerdjikov-Ivanov Hierarchy Through the Riemann-Hilbert Method
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作者 jin-yan zhu Yong CHEN 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2024年第2期358-378,共21页
The Gerdjikov-Ivanov(GI)hierarchy is derived via recursion operator,in this article,we mainly investigate the third-order flow GI equation.In the framework of the Riemann-Hilbert method,the soliton matrices of the thi... The Gerdjikov-Ivanov(GI)hierarchy is derived via recursion operator,in this article,we mainly investigate the third-order flow GI equation.In the framework of the Riemann-Hilbert method,the soliton matrices of the third-order flow GI equation with simple zeros and elementary high-order zeros of Riemann-Hilbert problem are constructed through the standard dressing process.Taking advantage of this result,some properties and asymptotic analysis of single soliton solution and two soliton solution are discussed,and the simple elastic interaction of two soliton are proved.Compared with soliton solution of the classical second-order flow,we find that the higher-order dispersion term affects the propagation velocity,propagation direction and amplitude of the soliton.Finally,by means of a certain limit technique,the high-order soliton solution matrix for the third-order flow GI equation is derived. 展开更多
关键词 Gerdjikov-Ivanov hierarchy third-order flow GI equation Riemann-Hilbert method high-order soliton
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