Chinese quality control indices for standardized diagnosis and treatment of gastric cancer(2022 edition)

Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.

Caveolae, caveolin-1 and cavin-1: Emerging roles in pulmonary hypertension

Caveolae are flask-shaped invaginations of cell membrane that play a significant structural and functional role. Caveolae harbor a variety of signaling molecules and serve to receive, concentrate and transmit extracellular signalsacross the membrane. Caveolins are the main structural proteins residing in the caveolae. Caveolins and another category of newly identified caveolae regulatory proteins, named cavins, are not only responsible for caveolae formation, but also interact with signaling complexes in the caveolae and regulate transmission of signals across the membrane. In the lung, two of the three caveolin isoforms, i.e., cav-1 and-2, are expressed ubiquitously. Cavin protein family is composed of four proteins, named cavin-1(or PTRF for polymerase Ⅰ and transcript release factor), cavin-2(or SDPR for serum deprivation protein response), cavin-3(or SRBC for sdr-related gene product that binds to-c-kinase) and cavin-4(or MURC for muscle restricted coiled-coiled protein or cavin-4). All the caveolin and cavin proteins are essential regulators for caveolae dynamics. Recently, emerging evidence suggest that caveolae and its associated proteins play crucial roles in development and progression of pulmonary hypertension. The focus of this review is to outline and discuss the contrast in alteration of cav-1(cav-1),-2 and cavin-1(PTRF) expression and downstream signaling mechanisms between human and experimental models of pulmonary hypertension.

Al基含能结构材料的Johnson-Cook本构模型及失效参数研究

利用万能实验机和Hopkinson杆装置测试了Al基含能结构材料在不同温度下的静动态力学性能,分析实验结果得到了温度效应和应变率效应对材料力学性能的影响及该合金的Johnson-Cook本构模型参数.结合二维数字图像相关(DIC)方法,研究了Al基含能结构材料的失效应变与应力三轴度及温度之间的关系,得到了该合金的Johnson-Cook失效模型参数.通过平面撞击实验获得了Al基含能结构材料粒子速度和应力波波速之间的经验线性关系和该合金的Grüneisen系数.基于实验获得的材料本构关系和状态方程参数,完成了Al基含能结构材料超高速撞击多层间隔薄钢板的数值模拟,结果表明,数值模拟中靶板的毁伤模式、破孔直径及弹坑主要散布区和实验结果吻合.

基于线阵图像深度学习的电池组焊缝瑕疵检测

为实现对激光焊缝质量的高效检测,引入了线阵图像传感解决在线检测问题,提出了一种基于深度学习的焊缝瑕疵快速检测方法。首先,针对激光焊缝瑕疵,优化了基于YOLO(You only look once)的深度学习网络。其次,在实验数据集中加入了合适的锚框,以提高检测框定位信息的准确度,并通过多尺度特征融合技术提高了瑕疵的识别准确度。最后,制作数据集并提出了一种数据集预处理方法训练网络,提升了瑕疵的识别效果。实验结果表明,本方法对焊缝单孔、穿孔、凹槽瑕疵的总识别率大于94%,对尺寸为4096pixel×4000pixel的单张工件图像的检测时间为0.97s,相比传统超声、射线图像检测方法在检测速度方面有明显提升。

A fast-locking bang-bang phase-locked loop with adaptive loop gain controller

This paper proposes a fast-locking bang-bang phase-locked loop（BBPLL）. A novel adaptive loop gain controller（ALGC） is proposed to increase the locking speed of the BBPLL. A novel bang-bang phase/frequency detector（BBPFD） with adaptive-mode-selective circuits is proposed to select the locking mode of the BBPLL during the locking process. Based on the detected results of the BBPFD, the ALGC can dynamically adjust the overall gain of the loop for fast-locking procedure. Compared with the conventional BBPFD, only a few gates are added in the proposed BBPFD. Therefore, the proposed BBPFD with adaptive-mode-selective circuits is realized with little area and power penalties. The fast-locking BBPLL is implemented in a 65 nm CMOS technology. The core area of the BBPLL is 0.022 mm;. Measured results show that the BBPLL operates at a frequency range from0.6 to 2.4 GHz. When operating at 1.8 GHz, the power consumption is 3.1 mW with a 0.9-V supply voltage. With the proposed techniques, the BBPLL achieves a normalized locked time of 1.1μs @ 100 MHz frequency jump.The figure-of-merit of the fast-locking BBPLL is-334 dB.

Significant emission reductions of carbonaceous aerosols from residential coal burning by a novel stove

Carbonaceous aerosols(CA) are crucial components in the atmospheric PM_(2.5) and derived from diverse sources. One of the major sources for CA is from the incomplete combustion of bituminous coal that has been prevailingly used by household stoves in rural areas for heating during winter. To efficiently eliminate the CA emission, a new household stove(NHS) was developed based on a novel combustion technology and CA emissions from the NHS and a traditional household stove(THS) were comparably investigated under the actual stove operation conditions in a farmer’s house. Compared with the THS, the emission factors of organic carbon(OC), elemental carbon(EC), and water-soluble organic carbon(WSOC) from the NHS were reduced by 96%±1%, 98%±1%, and 91%±1% under the flaming process and 95%±1%, 96%±2%, and 83%±4% under the smoldering process, respectively. Additionally,the mass absorption efficiency of WSOC from the NHS reduced by 3 folds and the radiative forcing by WSOC relative to EC shrank remarkably by a factor of 3-8. Based on the reduction of emissions and light absorption of WSOC, the promotion of the NHS offers a possible solution to achieve the clean combustion of residential solid fuel.