A practical and metal-flee oxidative amidation of aldehydes with tetrazoles into 1,3,4-oxadiazoles has been de- veloped by employing tetrabutylammonium iodide （TBAI） as catalyst and tert-butyl hydroperoxide （TBHP）...A practical and metal-flee oxidative amidation of aldehydes with tetrazoles into 1,3,4-oxadiazoles has been de- veloped by employing tetrabutylammonium iodide （TBAI） as catalyst and tert-butyl hydroperoxide （TBHP） as oxidant. A wide range of 2,5-disubstituted 1,3,4-oxadiazoles can be conveniently generated in moderate to good yields. Gram-scale reaction was also realized in this catalytic system.展开更多
基金This project was financially supported by the National Natural Science Foundation of China （No. 21302014） and the Natural Science Foundation for Colleges and Universities of Jiangsu Province （No. 13KJB 150002）.
文摘A practical and metal-flee oxidative amidation of aldehydes with tetrazoles into 1,3,4-oxadiazoles has been de- veloped by employing tetrabutylammonium iodide （TBAI） as catalyst and tert-butyl hydroperoxide （TBHP） as oxidant. A wide range of 2,5-disubstituted 1,3,4-oxadiazoles can be conveniently generated in moderate to good yields. Gram-scale reaction was also realized in this catalytic system.
