Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel oils.In this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall catalyst.Compared with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an initiator.The sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of reaction.Furthermore,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in polarity.This work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

Few-layered hexagonal boron nitride nanosheets stabilized Pt NPs for oxidation promoted adsorptive desulfurization of fuel oil

A few-layered hexagonal boron nitride nanosheets stabilized platinum nanoparticles(Pt/h-BNNS)is engineered for oxidation-promoted adsorptive desulfurization(OPADS)of fuel oil.It was found that the few-layered structure and the defective sites of h-BNNS not only are beneficial to the stabilization of Pt NPs but also favor the adsorption of aromatic sulfides.By employing Pt/h-BNNS with a Pt loading amount of 1.19 wt%as the active adsorbent and air as an oxidant,a 98.0%sulfur removal over dibenzothiophene(DBT)is achieved along with a total conversion of the DBT to the corresponding sulfones(DBTO_(2)).Detailed experiments show that the excellent desulfurization activity originates from the few-layered structure of h-BNNS and the high catalytic activity of Pt NPs.In addition,the OPADS system with Pt/h-BNNS as the active adsorbent shows remarkable stability in desulfurization performance with the existence of different interferents such as olefin,and aromatic hydrocarbons.Besides,the Pt/h-BNNS can be recycled 12 times without a significant decrease in desulfurization performance.Also,a process flow diagram is proposed for deep desulfurization of fuel oil and recovery of high value-added products,which would promote the industrial application of such OPADS strategy.

Nucleotide excision repair gene polymorphisms and hepatoblastoma susceptibility in Eastern Chinese children:A five-center case-control study

Objective:Nucleotide excision repair(NER)plays a vital role in maintaining genome stability,and the effect of NER gene polymorphisms on hepatoblastoma susceptibility is still under investigation.This study aimed to evaluate the relationship between NER gene polymorphisms and the risk of hepatoblastoma in Eastern Chinese Han children.Methods:In this five-center case-control study,we enrolled 966 subjects from East China(193 hepatoblastoma patients and 773 healthy controls).The TaqMan method was used to genotype 19 single nucleotide polymorphisms(SNPs)in NER pathway genes,including ERCC1,XPA,XPC,XPD,XPF,and XPG.Then,multivariate logistic regression analysis was performed,and odds ratios(ORs)and 95%confidence intervals(95%CIs)were utilized to assess the strength of associations.Results:Three SNPs were related to hepatoblastoma risk.XPC rs2229090 and XPD rs3810366 significantly contributed to hepatoblastoma risk according to the dominant model(adjusted OR=1.49,95%CI=1.07−2.08,P=0.019;adjusted OR=1.66,95%CI=1.12−2.45,P=0.012,respectively).However,XPD rs238406 conferred a significantly decreased risk of hepatoblastoma under the dominant model(adjusted OR=0.68,95%CI=0.49−0.95;P=0.024).Stratified analysis demonstrated that these significant associations were more prominent in certain subgroups.Moreover,there was evidence of functional implications of these significant SNPs suggested by online expression quantitative trait loci(eQTLs)and splicing quantitative trait loci(sQTLs)analysis.Conclusions:In summary,NER pathway gene polymorphisms(XPC rs2229090,XPD rs3810366,and XPD rs238406)are significantly associated with hepatoblastoma risk,and further research is required to verify these findings.

Robust Parameter Identification Method of Adhesion Model for Heavy Haul Trains

A robust parameter identification method based on Kiencke model was proposed to solve the problem of the parameter identification accuracy being affected by the rail environment change and noise interference for heavy-duty trains. Firstly, a Kiencke stick-creep identification model was constructed, and the parameter identification task was transformed into a quadratic programming problem. Secondly, an iterative algorithm was constructed to solve the problem, into which a time-varying forgetting factor was added to track the change of the rail environment, and to solve the uncertainty problem of the wheel-rail environment. The Granger causality test was adopted to detect the interference, and then the weights of the current data were redistributed to solve the problem of noise interference in parameter identification. Finally, simulations were carried out and the results showed that the proposed method could track the change of the track environment in time, reduce the noise interference in the identification process, and effectively identify the adhesion performance parameters.

Research on Track Fastener Service Status Detection Based on Improved Yolov4 Model

As an important part of railway lines, the healthy service status of track fasteners was very important to ensure the safety of trains. The application of deep learning algorithms was becoming an important method to realize its state detection. However, there was often a deficiency that the detection accuracy and calculation speed of model were difficult to balance, when the traditional deep learning model is used to detect the service state of track fasteners. Targeting this issue, an improved Yolov4 model for detecting the service status of track fasteners was proposed. Firstly, the Mixup data augmentation technology was introduced into Yolov4 model to enhance the generalization ability of model. Secondly, the MobileNet-V2 lightweight network was employed in lieu of the CSPDarknet53 network as the backbone, thereby reducing the number of algorithm parameters and improving the model’s computational efficiency. Finally, the SE attention mechanism was incorporated to boost the importance of rail fastener identification by emphasizing relevant image features, ensuring that the network’s focus was primarily on the fasteners being inspected. The algorithm achieved both high precision and high speed operation of the rail fastener service state detection, while realizing the lightweight of model. The experimental results revealed that, the MAP value of the rail fastener service state detection algorithm based on the improved Yolov4 model reaches 83.2%, which is 2.83% higher than that of the traditional Yolov4 model, and the calculation speed was improved by 67.39%. Compared with the traditional Yolov4 model, the proposed method achieved the collaborative optimization of detection accuracy and calculation speed.

Remaining Useful Life Prediction of Rail Based on Improved Pulse Separable Convolution Enhanced Transformer Encoder

In order to prevent possible casualties and economic loss, it is critical to accurate prediction of the Remaining Useful Life (RUL) in rail prognostics health management. However, the traditional neural networks is difficult to capture the long-term dependency relationship of the time series in the modeling of the long time series of rail damage, due to the coupling relationship of multi-channel data from multiple sensors. Here, in this paper, a novel RUL prediction model with an enhanced pulse separable convolution is used to solve this issue. Firstly, a coding module based on the improved pulse separable convolutional network is established to effectively model the relationship between the data. To enhance the network, an alternate gradient back propagation method is implemented. And an efficient channel attention (ECA) mechanism is developed for better emphasizing the useful pulse characteristics. Secondly, an optimized Transformer encoder was designed to serve as the backbone of the model. It has the ability to efficiently understand relationship between the data itself and each other at each time step of long time series with a full life cycle. More importantly, the Transformer encoder is improved by integrating pulse maximum pooling to retain more pulse timing characteristics. Finally, based on the characteristics of the front layer, the final predicted RUL value was provided and served as the end-to-end solution. The empirical findings validate the efficacy of the suggested approach in forecasting the rail RUL, surpassing various existing data-driven prognostication techniques. Meanwhile, the proposed method also shows good generalization performance on PHM2012 bearing data set.

The role of prolactin/vasoinhibins in cardiovascular diseases

Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including 5.6–18 kDa fragments).Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization,including endothelial cell proliferation and migration,protease production,and apoptosis.However,their effects on vascular function and cardiovascular diseases are different or even contrary.In addition to the structure,secretion regulation,and signal transduction of PRL/vasoinhibins,this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases.

Analysis of clinical and pathological features of ciliary body medulloepithelioma

AIM:To analyze and summarize the clinical and pathological features of ciliary body medulloepithelioma.METHODS:The clinical and pathological data of 11 patients(11 eyes) who were diagnosed with ciliary body medulloepithelioma at Beijing Tongren Hospital,Capital Medical University,from 2007 to 2021 were retrospectively analyzed.RESULTS:The initial symptoms of 11 patients included vision loss(6 eyes),atrophia bulbi(1 eye),proptosis(2 eyes),and leukocoria(2 eyes).Most patients suffered with corneal opacity,anterior chamber flare and hyphema.Iris neovascularization and synechia,complicated cataract,and secondar y glaucoma occurred in several cases.Three patients even had lens subluxation and retinal detachment.B-scan ultrasonography showed vitreous opacity and a medium-high uneven echo mass in the eyeball.Ultrasound biomicroscopy examination showed a spherical or hemispherical ciliary body mass with uneven internal echoes and irregular cystic spaces.All of the 11 patients were diagnosed with malignant ciliary body medulloepithelioma by pathological evidence.In this study,6 patients had enucleation(2 patients had systemic chemotherapy after surgery),and the other 5 patients had local tumor resection(1 patient had plaque radiotherapy after surgery).CONCLUSION:Ciliary body medulloepithelioma is a rare intraocular tumor and may be easily confused with retinoblastoma.Analyzing the clinical and pathological features of ciliary body medulloepithelioma is useful to further understand ciliary body medulloepithelioma,and can make an accurate diagnosis and better treatment.

Investigation of the Thermal Decomposition Behavior of Oleuropein with Many Pharmacological Activities from Olive by Thermogravimetry

Due to the existence of poly-hydroxyl structures,the temperature may have an effect on the thermal stability of oleuropein for its applications.In the current study,the thermal decomposition process and kinetics behavior of oleuropein from the olive resource were researched by thermogravimetric theoretical analysis methods and non-isothermal kinetics simulation.The results of thermogravimetry analysis showed the whole thermal decomposi-tion process of oleuropein involved two stages,with 21.22%of residue.It was also revealed that high heating rates of more than 20 K min^(-1) led to significant thermal hysteresis and inhibited the whole thermal decomposition behavior of oleuropein.Moreover,an investigation of the thermal decomposition kinetics indicated that the non-isothermal decomposition behavior followed a D3 model during thefirst stage(three-dimensional diffusion,Jander equation)and a D1 model in the second stage(one-dimensional diffusion).For thefirst and second ther-mal decomposition stages,the Kissinger,Friedman,Flynn-Wall-Ozawa,and Coats–Redfern four methods were applied to determine the activation energy(E=143.72 and 247.01 kJ mol^(-1))and Arrhenius preexponential factor(ln A=26.34 and 42.45 min^(-1)),respectively.Therefore,the study will provide good theoretical guidance for ther-mal stability and thermal transformation application of oleuropein.It will be suitable for low-temperature appli-cations in the cosmetic,food supplement and pharmaceutical industries.

Synergistically constructed lamination-like network of redox-active polyimide and MXene via π-π interactions for aqueous NH_(4)^(+) storage

As a nonmetallic charge carrier,ammonium ion(NH_(4)^(+))has garnered significant attention in the construction of aqueous batteries due to its advantages of low molar mass,small hydration size and rapid diffusion in aqueous solutions.Polymers are a kind of potential electro-active materials for aqueous NH_(4)^(+)storage.However,traditional polymer electrodes are typically created by covering the bulky collectors with excessive additives,which could lead to low volume capacity and unsatisfactory stability.Herein,a nanoparticle-like polyimide(PI)was synthesized and then combined with MXene nanosheets to synergistically construct an additive-free and self-standing PI@MXene composite electrode.Significantly,the redox-active PI nanoparticles are enclosed between conductive MXene flakes to create a 3D lamination-like network that promotes electron transmission,while theπ-πinteractions existing between PI and MXene contribute to the enhanced structural integrity and stability within the composite electrode.As such,it delivers superior aqueous NH_(4)^(+)storage behaviors in terms of a notable specific capacity of 110.7 mA·h·cm^(–3) and a long lifespan with only 0.0064%drop each cycle.Furthermore,in-situ Raman and UV–Vis examinations provide evidence of reversible and stable redox mechanism of the PI@MXene composite electrode during NH_(4)^(+)uptake/removal,highlighting its significance in the area of electrochemical energy storage.

Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring

Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for IHB.Gelatin is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most tissues.This study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical programmability.The regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to 0.52.The negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological interfaces.The GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high conformability.Notably,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue restoration.The GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.

Opportunity and shift of nitrogen use in China

It is never an easy task for China to feed 1.4 billion people with only 7%of the world's arable land.With nearly 30%of the world's nitrogen(N)fertilizer applied,China achieves high crop yields while facing N pollution result-ing from excessive N input.Here,we calculate the farmland N budget on the national and regional scales.The N use efficiency(NUE)in China increased by 28.0%during 2005-2018.This improvement is due to the reduction in fertilization and the improvement of crop management.The fragmented farmland is changing to large-scale farmland with the increase in cultivated land area per rural population and the development of agricultural mech-anization.This opportunity brings more possibilities for precision farmland management,thus further improving NUE.The goal of an NUE of 0.6 may be achieved in the 2040s based on the current development trend.This striking N use shift in China has important implications for other developing countries.

Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer:a randomized phase Ⅲ ARTIST trial

The efficacy and safety of bevacizumab with modified irinotecan,leucovorin bolus,and 5-fluorouracil intravenous infusion(mIFL) in the first-line treatment of metastatic colorectal cancer(mCRC) has not been well evaluated in randomized clinical trials in Chinese patients.We conducted a phrase Ⅲ trial in which patients with previously untreated mCRC were randomized 2:1 to the mIFL [irinotecan(125 mg/m2),leucovorin(20 mg/m2) bolus,and 5-fluorouracil intravenous infusion(500 mg/m2) weekly for four weeks every six weeks] plus bevacizumab(5 mg/kg every two weeks) group and the mIFL group,respectively.Co-primary objectives were progression-free survival(PFS) and 6-month PFS rate.In total,214 patients were enrolled.Our results showed that addition of bevacizumab to mIFL significantly improved median PFS(4.2 months in the mIFL group vs.8.3 months in the bevacizumab plus mIFL group,P < 0.001),6-month PFS rate(25.0% vs.62.6%,P < 0.001),median overall survival(13.4 months vs.18.7 months,P = 0.014),and response rate(17% vs.35%,P = 0.013).Grades 3 and 4 adverse events included diarrhea(21% in the mIFL group and 26% in the bevacizumab plus mIFL group) and neutropenia(19% in the mIFL group and 33% in the bevacizumab plus mIFL group).No wound-healing complications or congestive heart failure occurred.Our results suggested that bevacizumab plus mIFL is effective and well tolerated as first-line treatment for Chinese patients with mCRC.Clinical benefit and safety profiles were consistent with those observed in pivotal phase Ⅲ trials with mainly Caucasian patients.

A poor performance in comprehensive geriatric assessment is associated with increased fall risk in elders with hypertension： a cross-sectional study

BackgroundFall 和严肃的秋天损害为长辈成为了一颗主要健康担心。包括血压和反高血压的药申请的许多因素作为秋天的危险被报导。这研究的目的 342 个老高血压病人是决定年龄是否联系了与 hypertension.MethodsA 在老病人与增加的秋天风险联系的全身的功能的衰落全部的(年龄 79.5 &#x000b1；6.7 年，男性 63.8%) 被招募到学习。全面衰老老人评价(CGA ) 包括关于每日的生活的活动(ADL ) 的大小，营养，认知，消沉，药方药的数字和临床的诊断的数字，被进行评估每个参加者的物理、心理的地位。秋天风险被莫尔斯秋天规模评估， Tinetti 性能面向的活动性评价(POMA ) 和最近的年里的秋天的历史。参加者根据 CGA 分数被组织进 tertiles。在 CGA 和秋天风险之间的关联与更高的 CGA 通过社会科学统计套装软体 18.0 .ResultsParticipants 被分析分数是可能的更旧，一个更低的身体团索引(BMI ) ，和心血管的疾病，长期的妨碍的肺的疾病(COPD ) ，脑血管的疾病和 osteoarthropathia 的更高的流行。在 CGA 的更高的 tertile 的参加者在更低的 tertile 比那些获得秋天风险的得到的增加的流行(P &#x0003c；0.01 T3 对 T1， P &#x0003c；0.01 T3 对 T2 ) 。关联分析和回归分析显示出在 CGA 和莫尔斯秋天规模之间的重要协会(P &#x0003c；0.001 ) ，以及 CGA 和 POMA (P &#x0003c；0.001 ) 。同时， CGA 部件也与增加秋天风险显示出合作关系。在调整年龄， BMI， benzodiazepine 使用，心血管的疾病，脑血管的疾病， COPD 和 osteoarthropathia 以后，最近的年和升起的莫尔斯秋天规模里的秋天的两历史显著地与 ADL 缺陷被联系(或：2.748， 95%CI：1.598-4.725 ) ，(或：3.310， 95%CI：1.893-5.788 ) 。减少的 Tinetti POMA 分数与微型心理的州的检查(MMSE ) 被联系(或：4.035， 95%CI：2.100-7.751 ) ， ADL (或：2.380， 95%CI：1.357 &#x02212； 4.175 ) 并且弄短的 MNA 形式(MNA-SF ) 缺陷(或：2.692， 95%CI：1.147 &#x02212； 6.319 ).ConclusionsIn 有高血压的老成年人，损害了物理、心理的功能与增加的秋天被联系风险。进一步的学习被要求为协会和有效干预调查可能的调停人。

Anti-apoptotic effect of Shudipingchan granule in the substantia nigra of rat models of Parkinson＇s disease

Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications in the long term. In the present study, we investigated the effect of Shudipingchan granule on neuronal apoptosis in a rat model of Parkinson＇s disease, established by injecting 6-hydroxydopamine into the substantia nigra pars compacta and ventral tegmental area. We then administered levodopa （20 mg/kg intraperitoneally, twice daily） with or without Shudipingchan granule （7.5 mL/kg intragastrically, twice daily）, for 4 weeks. The long-term use of levodopa accel- erated apoptosis of nigral cells and worsened behavioral symptoms by activating the extracellular signal-regulated kinase pathway and downstream apoptotic factors. However, administration of Shudipingchan granule with levodopa reduced expression of phosphorylated extracellular signal-regulated kinase 1/2 and Bax, increased tyrosine hydroxylase and Bcl-2, reduced apoptosis in the substantia nigra, and markedly improved dyskinesia. These findings suggest that Shudipingchan granule suppresses neuronal apoptosis by inhibiting the hyper- phosphorylation of extracellular signal-regulated kinase and downregulating expression of anti-apoptotic genes. Shudipingchan granule, used in combination with levodopa, can effectively reduce the symptoms of Parkinson＇s disease.

The characteristic and evolution of coal-forming swamp in Hanshuiquan district,Santanghu Coalfield, Xinjiang,NW China,during the Middle Jurassic: evidence from coal petrography,coal facies and sporopollen

Santanghu Coalfield is the largest integrated coalfield exploration area in China. The major coal seams developing in Xishanyao Formation (Middle Jurassic) are the high-quality steam coals characterized by large thickness, favorable horizontal continuity and high coal quality. In this paper, twenty-two samples were collected from the three typical boreholes in Hanshuiquan disirict, representing the 11 coal seam sequences (7#,8#,9#,13#, 14#,15#,17#,18#,19#,20#,22#), respectively. The petrographic characteristics of the coal-bearing sequence in Xishanyao Formation were firstly summarized systematicly, and then the coal-forming swamp characteristics and succession mechanism of the coal seam in Xishanyao Formation were defined by analyzing the samples. The maceral composition, structure, geochemical and geophysical characteristics of coal are in eluded in original genetic criteria of coal-forming swamp an alysis. And the composition of coal petrography, maceral and microlithotype are the most frequently used parameters. Coal is composed of microscopic constituents and inorganic substances. The Xishanyao Formation maceral mainly consists of vitrinite (65.74%-97.01 %), inert i nite (1.93%-34%), and the exinite shows the mode of regular change. The coal-forming swamp in Xishanyao Formation possesses the characteristics of mainly marsh, wet forest swamp facies, and shallow water covered forest swamp facies, and a few of coal seams distribute in the deep water covered forest swamp facies. In addition, the sporopollens in Xishanyao Formation are mainly Pinaceae evergreen broad leaf and needle-leaved plants. Osmundaceae, Cyatheaceae and Lygodiaceae, indicating that the warm and humid tropic-subtropical climate conductive to the persistent growth of coal-forming plants in the Middle Jurassic. The coal-forming swamp shows the characteristics of vertically upward fluctuation through the periodic transition. It indicates a shallow-deep-shallow change process of the water covered depth in the swamp. This is the prin ci pal factor for the formation of the high-quality and continuous coal seam in Hanshuiquan district, Santanghu Coalfield.

Expression of angiostatin cDNA in human gallbladder carcinoma cell line GBC-SD and its effect on endothelial proliferation and growth

瞄准：在癌房间在试管内和在试管内，和潜力为胆囊癌 angiostatin 基因治疗珍视的胆囊的生物学的行为上探索 angiostatin 起来规定的影响。方法：包含鼠科的 angiostatin 的 pcDNA3.1 (+) 的真核细胞的表示向量被限制 endonuclease 消化构造并且识别并且定序。recombinant 向量 pcDNA3.1-angiostatin 与向量和嘲笑控制是进有 Lipofectamine 2000，和 paralleled 的人的胆囊癌房间线 GBC-SD 的 transfected。抵抗克隆被 G418 过滤屏蔽。Angiostatin 抄写和蛋白质表示被 RT-PCR 检验，免疫荧光并且西方污点。上层清液被收集对待 endothelial。细胞增长和生长在试管内在显微镜下面被观察。结果：鼠科的 angiostatin cDNA 成功地被克隆进真核细胞的表示向量 pcDNA3.1 (+) 。在有 G418 的 transfection 和选择的 14 d 以后，宏观的抵抗房间克隆与 3.1 (+)-angiostatin 和向量控制的 pcDNA 在试验性的组 transfected 被形成。但是未经治疗的房间在嘲笑控制死了。Angiostatin 被 RT-PCR 检测，蛋白质表示被免疫荧光在试验性的组检测并且西方污点。在三个组的房间增长和生长在试管内在显微镜下面分别地被观察。没有有效差量处于在是有或没有 angiostatin 的 transfected 的组之间的 GBC-SD 细胞的生长速度被观察。有上层清液的术后疗法，有效差量在内皮被观察房间(ECV-304 ) 生长在试管内。细胞增长和生长被禁止。结论：Angiostatin 直接不禁止人的胆囊癌房间增长和生长在试管内，但是 angiostatin 的分泌物住在内皮房间增长和生长。

Hexagonal boron nitride:A metal-free catalyst for deep oxidative desulfurization of fuel oils

Oxidative desulfurization(ODS)has been proved to be an efficient strategy for the production of clean fuel oil.Numerous metal-based materials have been employed as excellent ODS catalysts,but being hindered by their high-cost and potential secondary pollution.In this work,we employed graphene analogous hexagonal boron nitride(h-BN)as a metal-free catalyst for ODS with hydrogen peroxide(H2O2)as the oxidant.The h-BN catalyst was characterized and proved to be a few-layered structure with relatively high specific surface areas.The h-BN catalyst showed a 99.4%of sulfur removal in fuel oil under the optimized reaction conditions.Besides,the h-BN can be recycled for 8 times without significant decrease in the catalytic performance.Detailed mechanism analysis found that it is the boron radicals in h-BN activated H2O2 to generate·OH species,which can readily oxidize sulfides to corresponding sulfones for separation.This work would provide another choice in choosing metal-free catalysts for ODS.

Association of the Asp312Asn and Lys751 Gln polymorphisms in the XPD gene with the risk of non-Hodgkin's lymphoma:evidence from a meta-analysis

Polymorphisms in DNA repair genes may alter DNA repair capacity and,consequently,lead to genetic instability and carcinogenesis.Several studies have investigated the association of the Asp312 Asn and Lys751 Gln polymorphisms in the xeroderma pigmentosum complementation group D {XPD) gene with the risk of non-Hodgkin's lymphoma(NHL),but the conclusions have been inconsistent.Therefore,we performed this meta-analysis to more precisely estimate these relationships.A systematic literature search was performed using the PubMed,Embase,and Chinese Biomedical(CBM) databases.Ultimately,6 studies of Asp312 Asn,comprising 3,095 cases and 3,306 controls,and 7studies of Lys751 Gln,consisting of 3,249 cases and 3,676 controls,were included.Pooled odds ratios(ORs) and 95%confidence intervals(CIs) were calculated to assess the strength of each association.Overall,no association was observed between the Asp312 Asn polymorphism and NHL risk(homozygous:OR = 1.11,95%CI = 0.94-1.32;heterozygous:OR = 1.00,95%CI = 0.89-1.11;recessive:OR = 1.12,95%CI = 0.95-1.31;dominant:OR = 1.02,95%CI = 0.92-1.13;and allele comparison:OR = 1.04,95%CI = 0.96-1.12) or between the Lys751 Gln polymorphism and NHL risk(homozygous:OR = 0.97,95%CI = 0.83-1.15;heterozygous:OR = 0.96,95%CI = 0.86-1.06;recessive:OR = 1.00,95%CI = 0.86-1.16;dominant:OR = 0.96,95%CI = 0.87-1.06;and allele comparison:OR = 0.98,95%CI = 0.91-1.05).Furthermore,subgroup analyses did not reveal any association between these polymorphisms and ethnicity,the source of the controls,or the NHL subtype.These results indicated that neither the Asp312 Asn nor Lys751 Gln XPD polymorphism was related to NHL risk.Large and well-designed prospective studies are required to confirm this finding.

3D-printing of integrated spheres as a superior support of phosphotungstic acid for deep oxidative desulfurization of fuel

Construction of catalysts with integral structure for oxidative reaction process is an essential promotion to catalysts in industrial application.In this work,a 3D printing method was employed to prepare 3D printed spheres(3D-PSs),followed by carbonization to form 3D carbon spheres(3D-CSs).Then,a 3D-CSs supported phosphotungstic acid(HPW/3D-CSs)was prepared for deep oxidative desulfurization.Compared with traditional powder catalysts,the as-prepared catalyst is easy to be operated and separated from oil products.The supported catalyst possesses excellent catalytic performance and the removal of DBT,4-MDBT and 4,6-DMDBT in fuel oil,reaching^100%of sulfur removal.The effects of various experimental parameters on desulfurization efficiency were considered to optimize reaction conditions.Moreover,the catalyst shows excellent thermal and chemical stability,with no obvious decrease in desulfurization activity after 5 cycles.GC–MS analysis indicates DBT sulfone was the solely oxidized product of DBT.