Objective: To explore the changes and significance of homocysteine (Hcy), high sensitivity C reactive protein (hs-CRP) and coagulation function indexes in patients with acute cerebral infarction. Methods: A total of 1...Objective: To explore the changes and significance of homocysteine (Hcy), high sensitivity C reactive protein (hs-CRP) and coagulation function indexes in patients with acute cerebral infarction. Methods: A total of 110 patients with acute cerebral infarction were selected as the observation group, According to the symptoms of acute cerebral infarction to 96 h, whether the symptoms of neurological deficit were aggravated, the patients in the observation group could be divided into the progressive group (n=65 case) and the non progressive group (n=45 case), and 110 cases with normal physical examination results were selected as control group at the same time. The levels of blood lipid metabolism, Hcy, hs-CRP and blood coagulation function were compared in each group. Results: Single factor analysis showed a statistically significant difference in blood lipid metabolism, Hcy, hs-CRP and coagulation function between groups. Compared with the index level in the control group, the levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB in the observation group were significantly higher than those in the control group, and the HDL level was significantly decreased, the difference was statistically significant. The levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB in the progression group were significantly higher than those in the non progressive group, HDL level was significantly lower than that in the non progressive group showing significant difference. Correlation analysis showed that the severity of acute cerebral infarction was positively correlated with the levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB, and negatively correlated with HDL level. Conclusion: There are abnormalities of blood lipid metabolism and coagulation function in patients with acute cerebral infarction, and the levels of Hcy and hs-CRP increase significantly. Detection of all indexes is of great significance for evaluating the severity of acute cerebral infarction.展开更多
基金National Natural Science Foundation of China(No.51367010)Science and Technology Program of Gansu Province(No.17JR5RA083)Program for Excellent Team of Scientific Research in Lanzhou Jiaotong University(No.201701)。
基金This study was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region(:2016E02C127).
文摘Objective: To explore the changes and significance of homocysteine (Hcy), high sensitivity C reactive protein (hs-CRP) and coagulation function indexes in patients with acute cerebral infarction. Methods: A total of 110 patients with acute cerebral infarction were selected as the observation group, According to the symptoms of acute cerebral infarction to 96 h, whether the symptoms of neurological deficit were aggravated, the patients in the observation group could be divided into the progressive group (n=65 case) and the non progressive group (n=45 case), and 110 cases with normal physical examination results were selected as control group at the same time. The levels of blood lipid metabolism, Hcy, hs-CRP and blood coagulation function were compared in each group. Results: Single factor analysis showed a statistically significant difference in blood lipid metabolism, Hcy, hs-CRP and coagulation function between groups. Compared with the index level in the control group, the levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB in the observation group were significantly higher than those in the control group, and the HDL level was significantly decreased, the difference was statistically significant. The levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB in the progression group were significantly higher than those in the non progressive group, HDL level was significantly lower than that in the non progressive group showing significant difference. Correlation analysis showed that the severity of acute cerebral infarction was positively correlated with the levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB, and negatively correlated with HDL level. Conclusion: There are abnormalities of blood lipid metabolism and coagulation function in patients with acute cerebral infarction, and the levels of Hcy and hs-CRP increase significantly. Detection of all indexes is of great significance for evaluating the severity of acute cerebral infarction.
