利用宏基因组学方法分析健康人群肠道微生物与其生理指标的关系

目的探究亚洲健康人群的肠道菌群组成特征及其与血压和年龄相关生理指标的关系。方法应用WGCNA分析,对22个健康个体肠道微生物细菌基因组进行解析。结果亚洲健康人肠道微生物相对丰度最高的细菌门水平分别是Firmicutes(厚壁菌门)、Bacteroidetes(拟杆菌门)以及Proteobacteria(变形菌门),并且在Proteobacteria中显示高差异性。WGCNA分析结果表明两个模块(yellow,green)中微生物物种丰富度分别与收缩压和舒张压以及年龄呈正相关(t=3.0981,P=0.0056;t=3.0159,P=0.0068;t=2.3908,P=0.0267)。其中Ruminococcus sp.(瘤胃球菌)、Oscillospiraceae sp.(颤螺菌)、Clostridium hathewayi(哈氏梭菌)与血压呈现显著正相关;Intestinibacter(肠杆菌)、Clostridium(梭菌)、Blautia(劳特菌)以及Veillonella(韦荣球菌)属下的Aypic、Tobetsuensis rogosae与年龄呈现正相关。抗性基因注释结果表明,年龄和血压相关核心菌群均富集有较多的大环内酯-林可酰胺-链霉素类、杆菌肽类以及四环素类抗生素抗性基因。其中多黏菌素类抗性基因仅存在于年龄相关核心菌群而氯霉素抗性基因仅存在于血压相关核心菌群。结论健康人肠道微生物物种丰度与血压以及年龄相关,肠道菌群可能在心血管疾病以及衰老过程中发挥重要影响。

Swiss Chinese Association Explores Southwest China’s Ethnic Minority Villages

A Swiss Chinese Association(SCA)delegation headed by former Zurich Mayor Dr.Thomas Wagner visited Southwest China’s Guizhou Province in May at the invitation of the Chinese People’s Association for Friendship with Foreign Countries(CPAFFC)and to a warm welcome from provincial Governor Chen Miner and Deputy Governor Meng Qiliang.It attended seminars on urban planning and vocational education in Guiyang,the provincial capital,and visited Maotai Distillery,a tea planta-

Eighth China-South Asia International Cultural Forum held in Yunnan

From Nov 5 to 8,2019,the eighth China-South Asia International Cultural Forum was held in Kunming,Yunnan province.The forum was hosted by the Chinese People’s Association for Friendship with Foreign Countries and the Yunnan government,and run by the Kunming municipal government and Yunnan People’s Association for Friendship with Foreign Countries,in cooperation with Yunnan University and the Anning municipal government.