Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filt...Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.展开更多
Salt plays a crucial role in food processing and consumption,and the rapid detection of chloride ions in food and feed has great significance for practical applications.In this work,Ag-based nanomaterials were deposit...Salt plays a crucial role in food processing and consumption,and the rapid detection of chloride ions in food and feed has great significance for practical applications.In this work,Ag-based nanomaterials were deposited on the surface of a flexible integrated electrochemical sensor for the detection of Cl-in food.In order to enhance the detection performance,a unique needle-tip structure was formed by manipulating the electro-engraving process during the electrodeposition growth.Theoretical calculations and electrochemical investigations have demonstrated that the dendrimer’s rich tip structure significantly enhanced its electrochemical performance.A sensitive and flexible integrated electrochemical sensor was creatively developed for the detection of Cl-using needletip effect-promoted Ag micro dendrimers.The sensor achieved quantitative detection of Cl-over a dynamic range of 10.0μM–100.0 mM,with a low limit of detection of 0.148μM.The flexible electrochemical sensor proposed in this work exhibited good repeatability,selectivity and recoveries in real food samples.展开更多
Dawei was in intensive care unit on a ventilator.He was declared brain death after a traffic accident.At visiting time,his younger brother Dayong told me their final decision to give up the subsequent treatment.“We ...Dawei was in intensive care unit on a ventilator.He was declared brain death after a traffic accident.At visiting time,his younger brother Dayong told me their final decision to give up the subsequent treatment.“We don’t have enough money and medical insurance,we can’t afford further treatment”,he said.展开更多
Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectio...Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectional study aims to investigate the current situation and change in county people's demand for endoscopy to promote the development of endoscopy centers in county hospitals in southeast China.Methods From October to December 2021,patients and their family members who came to the Gastroenterology Department in Suichang County People's Hospital of Zhejiang Province were randomly selected to complete the questionnaire.A total of 838 valid questionnaires were collected.Additionally,the original software data of the Endoscopy Center were sampled and retrieved(from October to December every year from 2018 to 2021)for statistical analysis of real-world data.Those who would choose painless endoscopy the next time in the valid questionnaires were included in the painless endoscopy group,while those who would choose ordinary endoscopy the next time were included in the ordinary endoscopy group.Results The stepwise forward binary logistic regression model analysis showed that,patients with“secondhand smoke exposure”were more willing to choose painless endoscopy(OR=1.459,95%CI:1.050-2.028,p=0.025).However,patients with an education level of“primary and below”and“junior high school”,and patients who are suffering from“currently experiencing abdominal distension”,were more willing to choose ordinary endoscopy(OR=0.270,95%CI:0.149-0.488,p<0.001;OR=0.528,95%CI:0.330-0.845,p=0.008;OR=0.536,95%CI:0.334-0.861,p=0.010).Patients with previous experience in painless endoscopy tended to choose painless endoscopy the next time,while patients with previous experience in ordinary endoscopy tended to choose ordinary endoscopy the next time(χ^(2)=140.97,p<0.001).From 2018 to 2021,the proportion of painless endoscopy has increased yearly(p<0.001).Most patients indicated that they would“regularly review gastroenteroscopy”(477/838,56.9%).Conclusions With Suichang County of Zhejiang Province as the representative,the demand for painless endoscopy for people's gastrointestinal cancer detection in southeast China has been increasing yearly.The development of endoscopy centers in county-level hospitals can basically meet the demand growth.Meanwhile,advanced concepts such as comfortable medical care and regular follow-up are gradually popularized at the grassroots level in southeast China.展开更多
[Objective] The aim was to study the immobilization of laccase from Canoderma lucidum in three different sol-gel systems to find out the optimum ma- terials for laccase immobilization. [ Method ] Laccase from G. lucid...[Objective] The aim was to study the immobilization of laccase from Canoderma lucidum in three different sol-gel systems to find out the optimum ma- terials for laccase immobilization. [ Method ] Laccase from G. lucidum LYL 263 was immobilized in sodium alginate-gelatin, sodium alginate-chitosan and sodium alginate-gelatin-chitosan sol-gel systems, respectively; and the laccase activity was preliminarily analyzed. [ Result] The activity of laccase immobilized in sodium alginate-gelatin-chitosan was 2.14 folds and 2.75 folds respectively, compared to sodium alginate-gelatin and sodium alginate-chitosan; and this optimum system contained sodium alginate 2.0% , gelatin 1.0%, chitosan 0.3% and calcium chloride 56%. Benzoic acid was firstly used to embed immobilized laccase in this study, and single-factor experiments revealed that the activity of laccase could be effectively improved by suitable content of benzoic acid. The optimal conditions for laccase immobilization in the system were be^oie acid 2 retool/L, glutaraldehyde 0.32%, cross-linking reaction time 50 rain and enzyme concentration 10.0% ; and then the activity of the immobilized enzyme reached 635.7 U/g with these conditions. The thermal stability of the immobilized laccase was higher than free lac- case, and the activity of immobilized enzyme treated by freeze-drying was 1.59 folds compared to the non-freeze-dried, but the freeze-dried immobilized laccase had poor operational stability. [ Conclusion] The compositions of the material had significant influence on laccase immobilization and this study will provide reference to select materials for immobilization of laccase from G. lacidum LYL 263.展开更多
AIM:To evaluate the clinical significance of checking episcleral venous fluid wave(EVFW)during gonioscopyassisted transluminal trabeculotomy(GATT)in patients with open angle glaucoma(OAG).METHODS:This retrospective ca...AIM:To evaluate the clinical significance of checking episcleral venous fluid wave(EVFW)during gonioscopyassisted transluminal trabeculotomy(GATT)in patients with open angle glaucoma(OAG).METHODS:This retrospective case series study comprised 30 patients(45 eyes)with OAG underwent GATT.The location and extent of EVFW were examined and graded after intraoperative compression flushing of the anterior chamber angle during the operation.Patients were followed up for 1y.A complete success for surgery is defined as a postoperative intraocular pressure(IOP)<18 mm Hg without any anti-glaucoma medication.IOP<18 mm Hg with less than two anti-glaucoma medications is defined as qualified success,while the control of IOP requiring three anti-glaucoma medications is considered as unsuccess.RESULTS:The mean IOP was 35.38±7.16 mm Hg before surgery and 15.52±4.22 mm Hg 1y after surgery(P<0.01).The average number of anti-glaucoma medication was 2.8±1.2(2-4)preoperation and 0.6±1.3(0-3)1y postoperation(P<0.01).The success rate of the operation was 93.33%.Complete success rate was 66.67%,qualified success rate was 26.67%,and 6.66%of unsuccessful cases required reoperation.EVFW of all cases was grade 2-4,and the percentages of grade 2,3 and 4 were 33.33%,40.0%and 26.67%,respectively.The distribution and percentage of EVFW were inferior(36%),nasal(28%),superior(20%),and temporal(16%).The EVFW grade of complete success patients was 3.4±0.6(3-4),and that of qualified success patients was 2.6±1.0(2-4).The larger the range of EVFW,the lower the IOP,and the better the IOP reduction effect.CONCLUSION:During GATT surgery,pressurized irrigation of anterior chamber to check EVFW can reduce the outflow resistance of aqueous humor and increase the effect of postoperative IOP.The range of EVFW is negatively correlated with postoperative IOP.Therefore,EVFW may be a valuable prognostic indicator for the success of GATT surgery.展开更多
The photonic crystal structure has attracted much attention due to its ability to confine light.In this paper,we present our study on an improved Smith-Purcell radiation from a simple metal photonic crystal excited by...The photonic crystal structure has attracted much attention due to its ability to confine light.In this paper,we present our study on an improved Smith-Purcell radiation from a simple metal photonic crystal excited by moving electrons.Different from the wide-band Smith-Purcell radiation from a single metal grating,the results show that the injected electrons could induce more dipole oscillations inside the multi-grating structure,and it leads to the enhancement of the radiation intensity.In addition,there are strong resonances in metal multi-grating structure,and the resonance characteristics may narrow the radiation band,which leads to a radiation with an obvious peak in the spectrum.Therefore,the multi-grating structure has the ability to enhance the radiation intensity and shape the radiation frequency band.By optimizing the structure parameters,coherent and tunable Smith-Purcell radiation can be realized,and it provides a potential way to develop band-controllable light or THz radiation source.展开更多
The diseases of sweet cherry caused by viruses and viroids have occurred in the main cherry producing areas of China and are increasing year by year, which has become an important factor affecting the yield and qualit...The diseases of sweet cherry caused by viruses and viroids have occurred in the main cherry producing areas of China and are increasing year by year, which has become an important factor affecting the yield and quality of sweet cherry. For this reason, this paper elaborated the prevention and countermeasures of virus diseases from six aspects, including soil treatment, cultivation of disease-free seedlings, prevention of disease and pest damage, reasonable pruning, water management, and treatment of virus diseases, in order to provide technical guidance for the disease resistance, high quality and high yield of facility cherry, as well as information reference for the further improvement of the technical system of virus disease prevention and cultivation of facility cherry.展开更多
文摘Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.
基金financially supported by Key Research and Development Program in Hubei Province(Grant No.2023BBB042)the Fundamental Research Funds for the Central Universities(Grant No.2662023GXQD001)Key Laboratory of on Site Processing Equipment for Agricultural Products,Ministry of Agriculture and Rural Affairs(Grant No.2016NYZD2202).
文摘Salt plays a crucial role in food processing and consumption,and the rapid detection of chloride ions in food and feed has great significance for practical applications.In this work,Ag-based nanomaterials were deposited on the surface of a flexible integrated electrochemical sensor for the detection of Cl-in food.In order to enhance the detection performance,a unique needle-tip structure was formed by manipulating the electro-engraving process during the electrodeposition growth.Theoretical calculations and electrochemical investigations have demonstrated that the dendrimer’s rich tip structure significantly enhanced its electrochemical performance.A sensitive and flexible integrated electrochemical sensor was creatively developed for the detection of Cl-using needletip effect-promoted Ag micro dendrimers.The sensor achieved quantitative detection of Cl-over a dynamic range of 10.0μM–100.0 mM,with a low limit of detection of 0.148μM.The flexible electrochemical sensor proposed in this work exhibited good repeatability,selectivity and recoveries in real food samples.
基金supported by grants from the Zhejiang Natural Science Foundation(LQ20H030005)the Zhejiang Health Technology Project(2019RC153 and 2020KY126)。
文摘Dawei was in intensive care unit on a ventilator.He was declared brain death after a traffic accident.At visiting time,his younger brother Dayong told me their final decision to give up the subsequent treatment.“We don’t have enough money and medical insurance,we can’t afford further treatment”,he said.
基金supported by the National Natural Science Foundation of China(82073160).
文摘Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectional study aims to investigate the current situation and change in county people's demand for endoscopy to promote the development of endoscopy centers in county hospitals in southeast China.Methods From October to December 2021,patients and their family members who came to the Gastroenterology Department in Suichang County People's Hospital of Zhejiang Province were randomly selected to complete the questionnaire.A total of 838 valid questionnaires were collected.Additionally,the original software data of the Endoscopy Center were sampled and retrieved(from October to December every year from 2018 to 2021)for statistical analysis of real-world data.Those who would choose painless endoscopy the next time in the valid questionnaires were included in the painless endoscopy group,while those who would choose ordinary endoscopy the next time were included in the ordinary endoscopy group.Results The stepwise forward binary logistic regression model analysis showed that,patients with“secondhand smoke exposure”were more willing to choose painless endoscopy(OR=1.459,95%CI:1.050-2.028,p=0.025).However,patients with an education level of“primary and below”and“junior high school”,and patients who are suffering from“currently experiencing abdominal distension”,were more willing to choose ordinary endoscopy(OR=0.270,95%CI:0.149-0.488,p<0.001;OR=0.528,95%CI:0.330-0.845,p=0.008;OR=0.536,95%CI:0.334-0.861,p=0.010).Patients with previous experience in painless endoscopy tended to choose painless endoscopy the next time,while patients with previous experience in ordinary endoscopy tended to choose ordinary endoscopy the next time(χ^(2)=140.97,p<0.001).From 2018 to 2021,the proportion of painless endoscopy has increased yearly(p<0.001).Most patients indicated that they would“regularly review gastroenteroscopy”(477/838,56.9%).Conclusions With Suichang County of Zhejiang Province as the representative,the demand for painless endoscopy for people's gastrointestinal cancer detection in southeast China has been increasing yearly.The development of endoscopy centers in county-level hospitals can basically meet the demand growth.Meanwhile,advanced concepts such as comfortable medical care and regular follow-up are gradually popularized at the grassroots level in southeast China.
基金Supported by Guangxi Provincial Natural Science Foundation ( 2011GXNSFA018080)General Science Research Program of Educational Commission of Guangxi Province of China [( 2009) No. 25]Phase Ⅱ of the Program for the Construction of Guangxi Key Laboratory of Environmental Engineering and Protection and Assessment
文摘[Objective] The aim was to study the immobilization of laccase from Canoderma lucidum in three different sol-gel systems to find out the optimum ma- terials for laccase immobilization. [ Method ] Laccase from G. lucidum LYL 263 was immobilized in sodium alginate-gelatin, sodium alginate-chitosan and sodium alginate-gelatin-chitosan sol-gel systems, respectively; and the laccase activity was preliminarily analyzed. [ Result] The activity of laccase immobilized in sodium alginate-gelatin-chitosan was 2.14 folds and 2.75 folds respectively, compared to sodium alginate-gelatin and sodium alginate-chitosan; and this optimum system contained sodium alginate 2.0% , gelatin 1.0%, chitosan 0.3% and calcium chloride 56%. Benzoic acid was firstly used to embed immobilized laccase in this study, and single-factor experiments revealed that the activity of laccase could be effectively improved by suitable content of benzoic acid. The optimal conditions for laccase immobilization in the system were be^oie acid 2 retool/L, glutaraldehyde 0.32%, cross-linking reaction time 50 rain and enzyme concentration 10.0% ; and then the activity of the immobilized enzyme reached 635.7 U/g with these conditions. The thermal stability of the immobilized laccase was higher than free lac- case, and the activity of immobilized enzyme treated by freeze-drying was 1.59 folds compared to the non-freeze-dried, but the freeze-dried immobilized laccase had poor operational stability. [ Conclusion] The compositions of the material had significant influence on laccase immobilization and this study will provide reference to select materials for immobilization of laccase from G. lacidum LYL 263.
基金Supported by Sichuan Science and Technology Program(No.2021YFS0214).
文摘AIM:To evaluate the clinical significance of checking episcleral venous fluid wave(EVFW)during gonioscopyassisted transluminal trabeculotomy(GATT)in patients with open angle glaucoma(OAG).METHODS:This retrospective case series study comprised 30 patients(45 eyes)with OAG underwent GATT.The location and extent of EVFW were examined and graded after intraoperative compression flushing of the anterior chamber angle during the operation.Patients were followed up for 1y.A complete success for surgery is defined as a postoperative intraocular pressure(IOP)<18 mm Hg without any anti-glaucoma medication.IOP<18 mm Hg with less than two anti-glaucoma medications is defined as qualified success,while the control of IOP requiring three anti-glaucoma medications is considered as unsuccess.RESULTS:The mean IOP was 35.38±7.16 mm Hg before surgery and 15.52±4.22 mm Hg 1y after surgery(P<0.01).The average number of anti-glaucoma medication was 2.8±1.2(2-4)preoperation and 0.6±1.3(0-3)1y postoperation(P<0.01).The success rate of the operation was 93.33%.Complete success rate was 66.67%,qualified success rate was 26.67%,and 6.66%of unsuccessful cases required reoperation.EVFW of all cases was grade 2-4,and the percentages of grade 2,3 and 4 were 33.33%,40.0%and 26.67%,respectively.The distribution and percentage of EVFW were inferior(36%),nasal(28%),superior(20%),and temporal(16%).The EVFW grade of complete success patients was 3.4±0.6(3-4),and that of qualified success patients was 2.6±1.0(2-4).The larger the range of EVFW,the lower the IOP,and the better the IOP reduction effect.CONCLUSION:During GATT surgery,pressurized irrigation of anterior chamber to check EVFW can reduce the outflow resistance of aqueous humor and increase the effect of postoperative IOP.The range of EVFW is negatively correlated with postoperative IOP.Therefore,EVFW may be a valuable prognostic indicator for the success of GATT surgery.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61921002,62171098,and 92163204)。
文摘The photonic crystal structure has attracted much attention due to its ability to confine light.In this paper,we present our study on an improved Smith-Purcell radiation from a simple metal photonic crystal excited by moving electrons.Different from the wide-band Smith-Purcell radiation from a single metal grating,the results show that the injected electrons could induce more dipole oscillations inside the multi-grating structure,and it leads to the enhancement of the radiation intensity.In addition,there are strong resonances in metal multi-grating structure,and the resonance characteristics may narrow the radiation band,which leads to a radiation with an obvious peak in the spectrum.Therefore,the multi-grating structure has the ability to enhance the radiation intensity and shape the radiation frequency band.By optimizing the structure parameters,coherent and tunable Smith-Purcell radiation can be realized,and it provides a potential way to develop band-controllable light or THz radiation source.
基金Supported by Class A Project of Scientific Research Development Program of Colleges and Universities in Shandong Province (J17KA155)。
文摘The diseases of sweet cherry caused by viruses and viroids have occurred in the main cherry producing areas of China and are increasing year by year, which has become an important factor affecting the yield and quality of sweet cherry. For this reason, this paper elaborated the prevention and countermeasures of virus diseases from six aspects, including soil treatment, cultivation of disease-free seedlings, prevention of disease and pest damage, reasonable pruning, water management, and treatment of virus diseases, in order to provide technical guidance for the disease resistance, high quality and high yield of facility cherry, as well as information reference for the further improvement of the technical system of virus disease prevention and cultivation of facility cherry.
