Efficacy of acupuncture at ghost points combined with fluoxetine in treating depression:A randomized study

BACKGROUND Depression affects more than 350 million people worldwide.In China,4.2%(54 million people)of the total population suffers from depression.Psychotherapy has been shown to change cognition,improve personality,and enhance the ability to cope with difficulties and setbacks.While pharmacotherapy can reduce symptoms,it is also associated with adverse reactions and relapse after drug withdrawal.Therefore,there has been an increasing emphasis placed on the use of non-pharmacological therapies for depression.The hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of depression.AIM To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with depression.METHODS This randomized controlled trial included patients with mild to moderate depression(n=160).Patients received either acupuncture at ghost points combined with fluoxetine(n=80)or fluoxetine alone(control group,n=80).Needles were retained in place for 30 min,5 times a week;three treatment cycles were administered.The Mann–Whitney U test was used to compare functional magnet resonance imaging parameters,Hamilton depression rating scale(HAMD)scores,and self-rating depression scale(SDS)scores between the acupuncture group and control group.RESULTS There were no significant differences in HAMD or SDS scores between the acupuncture group and control group,before or after 4 wk of treatment.The acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment(P<0.05).The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf,left posterior cingulate gyrus,left middle occipital gyrus,and left inferior occipital gyrus after 8 wk.The acupuncture group also had significantly higher values for the right inferior frontal gyrus,right insula,and right hippocampus(P<0.05).After 8 wk of treatment,the effective rates of the acupuncture and control groups were 51.25%and 36.25%,respectively(P<0.05).CONCLUSION The study results suggest that acupuncture at ghost points combined with fluoxetine is more effective than fluoxetine alone for the treatment of patients with mild to moderate depression.

Predictive defect detection for prototype additive manufacturing based on multi-layer susceptibility discrimination

This paper presents a predictive defect detection method for prototype additive manufacturing(AM)based on multilayer susceptibility discrimination(MSD).Most current methods are significantly limited by merely captured images,disregarding the differences between layer-by-layer manufacturing approaches,without combining transcendental knowledge.The visible parts,originating from the prototype of conceptual design,are determined based on spherical flipping and convex hull theory,on the basis of which theoretical template image(TTI)is rendered according to photorealistic technology.In addition,to jointly consider the differences in AM processes,the finite element method(FEM)of transient thermal-structure coupled analysis was conducted to probe susceptible regions where defects appeared with a higher possibility.Driven by prior knowledge acquired from the FEM analysis,the MSD with an adaptive threshold,which discriminated the sensitivity and susceptibility of each layer,was implemented to determine defects.The anomalous regions were detected and refined by superimposing multiple-layer anomalous regions and comparing the structural features extracted using the Chan-Vese(CV)model.A physical experiment was performed via digital light processing(DLP)with photosensitive resin of a non-faceted scaled V-shaped engine block prototype with cylindrical holes using a non-contact profilometer.This MSD method is practical for detecting defects and is valuable for a deeper exploration of barely visible impact damage(BVID),thereby reducing the defect of prototypical mechanical parts in engineering machinery or process equipment via intellectualized machinevision.

Collisionless tool orientation smoothing above blade stream surface using NURBS envelope

In five-axis machining,tool orientation above a blade stream surface may lead to tool collision and a decrease in workpiece rigidity.Hence,collisionless tool orientation smoothing(TOS)becomes an important issue.On the basis of a constant scallop height tool path,the triangular facets in the faces,vertices format are constructed from cutter contact(CC)using the Voronoi incremental algorithm.The cutter location(CL)points candidate set is represented by an oblique elliptic cone whose vertex lies at CC using NURBS envelope.Whether the CL point is above its CC is judged by the dot product between the normal vector and the point on triangulation nearest to the CL point.The curvatures at CC are obtained by fitting a moving least square(MLS) quadratic patch to the local neighborhood of a vertex and calculating eigenvectors and eigenvalues of the Hessian matrix.Triangular surface elastic energy is employed as the weight in selection from the NURBS envelope.The collision is judged by NURBS surface intersection.TOS can then be expressed by selecting a CL point for each CC point and converted into a numerical control(NC)code automatically according to the postprocessor type of the machine center.The proposed method is verified by finishing of a cryogenic turboexpander impeller of air separation equipment.

考虑结构柔性的多激励机构关联性能强化设计方法（英文）

目的:揭示多场耦合环境下的多自由度系统中柔性结构对机构性能的影响规律,以低压断路器多激励操动机构为例,研究机-电-热-磁耦合的多模态分断性能强化设计方法,提高短路、过载、欠压、缺相和漏电时的瞬时、短延时和长延时分断性能。创新点:1.将多自由度刚柔耦合系统的物理坐标转换为模态坐标,实现模型降阶和关联性能解耦;2.运用类比法获得零部件对关联性能的影响度,通过实验设计将难测属性转化为关联易测量,实现机构的关联性能强化。方法:1.将多自由度的含柔体动力学系统转化为自由度乘模态阶的方阵,通过Craig-Bampton逐层降阶模态矩阵,并由迭代步反馈激活柔体的高阶模态;2.通过类比求解霍尔姆力、洛伦兹力、电动斥力、电磁力和悬臂双金属片激励力,获得多激励系统机构关节的性能关联程度;3.通过低压断路器电气实验和温升实验,验证零件结构柔性对机构的性能影响规律,实现多激励机构多模态分断性能强化设计。结论:1.提出的考虑结构柔性的多激励机构关联性能强化设计方法有助于提高多自由度动力学系统的瞬态性能;2.结构柔性降低分断性能,使高频分断中的峰值段性能退化;3.基于实验设计的电气实验和温升实验,验证了多激励机构关联性能强化方法的有效性。