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Selective photosynthesis of Z-olefins through crystalline metal-organic cage-initiated expeditious cascade reactions
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作者 Jia-Ni Lu Yunze Huang +6 位作者 Yuan-Sheng Xia Long-Zhang Dong Lei Zhang jing-jing liu Lan-Gui Xie Jiang liu Ya-Qian Lan 《Carbon Energy》 SCIE EI CAS CSCD 2024年第3期118-131,共14页
The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical industry.Moreover,flammable and explosive hydrogen as the common hydrogen source o... The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical industry.Moreover,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial production.Herein,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton source.Before the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen production.Among them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple cycles.This“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions. 展开更多
关键词 alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis Z-olefins
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Impact of task-oriented training based on acupuncture rehabilitation on upper extremity function and quality of life of patients with early stroke
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作者 Hong-Guang liu jing-jing liu +5 位作者 Yan-Ping Wang Hong-Ying Wang Ao Sun Yue Zhou Ming-Ming Cai Ming-Ming Qi 《World Journal of Clinical Cases》 SCIE 2024年第19期3776-3784,共9页
BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact... BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact of task-oriented training based on acupuncture therapy on upper extremity function in patients with early stroke.METHODS Patients with early stroke hemiplegia who visited our hospital between January 2021 and October 2022 were divided into a control group and an observation group,each with 50 cases.The control group underwent head acupuncture plus routine upper limb rehabilitation training(acupuncture therapy).In addition to acupuncture and rehabilitation,the observation group underwent upper limb task-oriented training(30 min).Each group underwent treatment 5 d/wk for 4 wk.Upper extremity function was assessed in both groups using the Fugl-Meyer Assessment-Upper Extremity(FMA-UE),Wolf Motor Function Rating Scale(WMFT),modified Barthel Index(MBI),and Canadian Occupational Performance Measure(COPM).Quality of life was evaluated using the Short-Form 36-Item Health Survey(SF-36).Clinical efficacy of the interventions was also evaluated.RESULTS Before intervention,no significant differences were observed in the FMA-UE,MBI,and WMFT scores between the two groups(P>0.05).After intervention,the FMA-UE,WMFT,MBI,COPM-Functional Mobility and Satisfaction,and SF-36 scores increased in both groups(P<0.05),with even higher scores in the observation group(P<0.05).The observation group also obtained a higher total effective rate than the control group(P<0.05).CONCLUSION Task-oriented training based on acupuncture rehabilitation significantly enhanced upper extremity mobility,quality of life,and clinical efficacy in patients with early stroke. 展开更多
关键词 STROKE Acupuncture rehabilitation Task-oriented training Upper extremity training
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The Infiuence of Velocity-dependent Correction Factor on Proton Decay Reactions in Massive White Dwarfs
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作者 jing-jing liu Dong-Mei liu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第3期169-179,共11页
Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-... Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-section.We find that a strong suppression controls the monopole catalysis of nucleon decay by the correction factor.The maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),respectively.The luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation. 展开更多
关键词 astroparticle physics-nuclear reactions-nucleosynthesis-abundances-(stars) white dwarfs
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Clinical observation of gastrointestinal function recovery in patients after hepatobiliary surgery
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作者 Hua-Jun Zeng jing-jing liu Ying-Chun Yang 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第1期76-84,共9页
BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and vitamins.AIM To investigate the recovery of gastrointestinal function in patients af... BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and vitamins.AIM To investigate the recovery of gastrointestinal function in patients after hepato-biliary surgery and identify effective rehabilitation measures.METHODS A total of 200 patients who underwent hepatobiliary surgery in our hospital in 2022 were selected as the study subjects.They were divided into a control group and a study group based on the extent of the surgery,with 100 patients in each group.The control group received routine treatment,while the study group re-ceived targeted interventions,including early enteral nutrition support,drinking water before gas discharge,and large bowel enema,to promote postoperative gastrointestinal function recovery.The recovery of gastrointestinal function was compared between the two groups.RESULTS Compared with the control group,patients in the study group had better recovery of bowel sounds and less accumulation of fluids in the liver bed and gallbladder fossa(P<0.05).They also had shorter time to gas discharge and first meal(P<0.05),higher overall effective rate of gastrointestinal function recovery(P<0.05),and lower incidence of postoperative complications(P<0.05).CONCLUSION Targeted nursing interventions(early nutritional support,drinking water before gas discharge,and enema)can effectively promote gastrointestinal function recovery in patients undergoing hepatobiliary surgery and reduce the incidence of complications,which is worthy of promotion. 展开更多
关键词 Liver and gallbladder patients Gastrointestinal function Postoperative recovery
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贝伐珠单抗致过敏性休克1例 被引量:2
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作者 刘静静 康艳生 +3 位作者 王晓琴 张伟 张鹤凤 王彤 《药物流行病学杂志》 CAS 2023年第1期103-106,共4页
分析1例贝伐珠单抗致过敏性休克的临床特点和相关因素,为临床安全用药提供参考。1例右肺腺癌患者第10次使用贝伐珠单抗进行单药化疗,出现心慌、气短、口唇发绀、指脉氧饱和度降低、心率加快、血压测不出、短暂全身抽搐和一过性心跳停止... 分析1例贝伐珠单抗致过敏性休克的临床特点和相关因素,为临床安全用药提供参考。1例右肺腺癌患者第10次使用贝伐珠单抗进行单药化疗,出现心慌、气短、口唇发绀、指脉氧饱和度降低、心率加快、血压测不出、短暂全身抽搐和一过性心跳停止,经抢救后患者痊愈,并终止了贝伐珠单抗对原发病的治疗。贝伐珠单抗为低敏性药物,但多疗程治疗的肿瘤患者应警惕严重的/罕见的过敏反应,建议在具备抢救设施的环境中在使用。 展开更多
关键词 贝伐珠单抗 过敏性休克 药品不良反应 病例报告
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Mid-infrared lightly Er^(3+)-doped CaF_(2)laser under acousto–optical modulation
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作者 赵元昊 宗梦雨 +4 位作者 董佳昊 张振 刘晶晶 刘杰 苏良碧 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第3期239-243,共5页
A 1.7-at.%Er:CaF_(2)crystal was synthesized by temperature gradient method.The Er:CaF_(2)crystal was applied in acousto-optically Q-switched laser at mid-infrared region for the first time.Using a Te O_(2)-based cryst... A 1.7-at.%Er:CaF_(2)crystal was synthesized by temperature gradient method.The Er:CaF_(2)crystal was applied in acousto-optically Q-switched laser at mid-infrared region for the first time.Using a Te O_(2)-based crystal as Q-switcher,we obtained a laser diode(LD)end-pumped Er:CaF_(2)laser with the highest single pulse energy up to 0.49 mJ and maximum peak power of 0.56 kW under 6.34-W absorbed pump power.The implication of these results is that the low-doped Er:CaF_(2)crystal exhibits promising optical properties in solid-state lasers. 展开更多
关键词 mid-infrared laser Er:CaF_(2)laser acousto-optical modulation
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经ERCP途径与PTCD途径治疗恶性梗阻性黄疸疗效比较的系统评价 被引量:22
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作者 薛鸿 岳鹏 +4 位作者 刘晶晶 魏宁 杨侃 马敏杰 韩彪 《中国内镜杂志》 2019年第3期17-26,共10页
目的系统评价经内镜逆行胰胆管造影术(ERCP)与经皮肝穿刺胆道引流术(PTCD)治疗恶性梗阻性黄疸(MOJ)的临床疗效。方法通过计算机检索数据库PubMed、EMBASE、The Cochrane Library、CNKI、万方数据库和CBM,搜索国内外公开发表的有关经ERC... 目的系统评价经内镜逆行胰胆管造影术(ERCP)与经皮肝穿刺胆道引流术(PTCD)治疗恶性梗阻性黄疸(MOJ)的临床疗效。方法通过计算机检索数据库PubMed、EMBASE、The Cochrane Library、CNKI、万方数据库和CBM,搜索国内外公开发表的有关经ERCP途径或PTCD途径治疗MOJ的随机对照试验(RCT)和临床对照研究(CCT),检索时限从建库起到2018年5月。由两名评价员按纳入排除标准独立筛选文献、提取资料并评价纳入文献的偏倚风险后,使用Stata 12.0软件进行Meta分析。结果共纳入9个研究,其中2个RCT,7个CCT,共计994例患者。Meta分析结果显示:①手术成功率:ERCP组治疗低位MOJ手术成功率高于PTCD组(OR^=2.52,95%CI:1.26~5.04,P=0.009),而治疗高位MOJ手术成功率低于PTCD组(OR^=0.17,95%CI:0.07~0.41,P=0.000),两组总手术成功率差异无统计学意义(OR^=0.88,95%CI:0.52~1.49,P=0.631);②临床疗效:ERCP组治疗低位MOJ临床疗效高于PTCD组(O^R=5.80,95%CI:3.06~11.00,P=0.000),而治疗高位MOJ临床疗效低于PTCD组(OR^=0.13,95%CI:0.07~0.24,P=0.000),两组临床总疗效差异无统计学意义(O^R=1.10,95%CI:0.75~1.62,P=0.609);③并发症发生率:ERCP组治疗低位MOJ并发症发生率低于PTCD组(OR^=0.14,95%CI:0.06~0.32,P=0.000),而两组在高位MOJ并发症发生率(O^R=1.35,95%CI:0.66~2.78,P=0.414)和总并发症发生率(OR^=0.78,95%CI:0.39~1.57,P=0.489)上,差异无统计学意义。结论经ERCP途径和经PTCD途径治疗MOJ均可取得显著的临床疗效,对于低位梗阻患者ERCP途径更有优势,对于高位梗阻患者而言,PTCD途径更有优势。 展开更多
关键词 恶性梗阻性黄疸 经内镜逆行性胰胆管造影术 经皮肝穿刺胆道引流术 Meta分析
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Preliminary application of 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with advanced pancreatic cancer 被引量:13
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作者 Wei Huang Jian Lu +7 位作者 Ke-Min Chen Zhi-Yuan Wu Qing-Bin Wang jing-jing liu Ju Gong Zhi-Jin Chen Xiao-Yi Ding Zhong-Min Wang 《World Journal of Gastroenterology》 SCIE CAS 2018年第46期5280-5287,共8页
AIM To evaluate a 3 D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer. METHODS A retrospective analysis of our database was performed, and a total of 25 patients w... AIM To evaluate a 3 D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer. METHODS A retrospective analysis of our database was performed, and a total of 25 patients with pancreatic cancer who underwent iodine-125 seed implantation between January 2014 and November 2017 were analyzed. Of these, 12 implantations were assisted by a 3 D-printed coplanar template(group A), and 13 implantations performed freehand were selected as a control group(group B). A 3 D coplanar template was designed and printed according to a preoperative CT scan and treatment planning system. The iodine-125 seeds were then implanted using the template as a guide. Dosimetric verification was performed after implantation. Pre-and postoperative D90, V100, and V150 were calculated. The success rate of iodine-125 seed implantation, dosimetric parameters, and complications were analyzed and compared between the two groups.RESULTS Iodine-125 seed implantation was successfully performed in both groups. In group A, the median pre-and postoperative D90 values were 155.32 ± 8.05 Gy and 154.82 ± 16.43 Gy, respectively; the difference between these values was minimal and not statistically significant(P > 0.05). Postoperative V100 and V150 were 91.05% ± 4.06% and 64.54% ± 13.40%, respectively, which met the treatment requirement. A better dosimetric parameter was observed in group A than in group B, and the difference was statistically significant(V100: 91.05% ± 4.06% vs 72.91% ± 13.78%, P < 0.05). No major procedure-related complications were observed in either group. For group A, mild hemorrhage was observed in 1 patient with a peritoneal local hematoma due to mesenteric vein damage from the iodine-125 seed implantation needle. The hematoma resolved spontaneously without treatment. Postoperative blood amylase levels remained within the normal range for all patients.CONCLUSION A 3 D-printed coplanar template appears to be a safe and effective iodine-125 seed implantation guidance tool to improve implantation accuracy and optimize dosimetric distribution. 展开更多
关键词 3D PRINTING BRACHYTHERAPY IODINE-125 PANCREATIC cancer
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Internal limiting membrane dragging and peeling:a modified technique for macular holes closure surgery 被引量:4
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作者 Jie Peng Li-Hua Zhang +3 位作者 Chun-Li Chen jing-jing liu Xiu-Yu Zhu Pei-Quan Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第5期755-760,共6页
AIM:To introduce a modified technique of internal limiting membrane(ILM)centripetal dragging and peeling to treat idiopathic macular hole(IMH)and to observe the ILM-retina adhesive forces.METHODS:Twenty-six consecutiv... AIM:To introduce a modified technique of internal limiting membrane(ILM)centripetal dragging and peeling to treat idiopathic macular hole(IMH)and to observe the ILM-retina adhesive forces.METHODS:Twenty-six consecutive patients with stage 3 to 4 IMH and followed up at least six months were enrolled.All patients underwent complete par plana vitrectomy,ILM dragging and peeling,fluid and gas exchange,15%C3 F8 tamponade and 2-week prone position.The best corrected visual acuity,macular hole evaluation by optical coherence tomography,and complications were evaluated.RESULTS:The mean diameter of IMH was 524±148μm(range:201-683μm),with 21 cases(80.8%)greater than 400μm.ILM dragging and peeling were successfully performed in all cases.Most of the ILM-retina adhesive forces are severe(42.3%,11/26),followed by mild(38.5%,10/26),and moderate(19.2%,5/26).The mean follow-up duration was 21.2±6.1 mo.The IMH was closed in 25(96.3%)eyes.Visual acuity(logMAR)improved significantly from 1.2±0.6 preoperatively to 0.7±0.5 postoperatively(P<0.001).CONCLUSION:Preexisting ILM-retina adhesive force is found in IMH patients.With assistance of this force,this modified technique may help to release the IMH edges and improve the closure rate of large IMH. 展开更多
关键词 idiopathic macular hole internal limiting membrane adhesive force par plana vitrectomy
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Inhibition of NF-kB and Wnt/β-catenin/GSK3p Signaling Pathways Ameliorates Cardiomyocyte Hypertrophy and Fibrosis in Streptozotocin (STZ)-induced Type 1 Diabetic Rats 被引量:3
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作者 jing-jing liu Lu-mei SHENTU +6 位作者 Ning MA Li-ying WANG Gui-min ZHANG Ying SUN Yan WANG Jun LI Yan-ling MU 《Current Medical Science》 SCIE CAS 2020年第1期35-47,共13页
Type 1 diabetes mellitus(T1DM)is associated with an increased risk of diabetic cardiomyopathy(DCM).Nuclear factor kappa B(NF-kB)and Wnt/β-catenin/GSK3p have been demonstrated to play pathogenic roles in diabetes.In t... Type 1 diabetes mellitus(T1DM)is associated with an increased risk of diabetic cardiomyopathy(DCM).Nuclear factor kappa B(NF-kB)and Wnt/β-catenin/GSK3p have been demonstrated to play pathogenic roles in diabetes.In this study,we evaluated the roles of these two pathways in T1 DM-induced cardiomyopathy in rats.Streptozotocin(STZ)-induced type 1 diabetic rats were treated with pyrrolidine dithiocarbamate(PDTC)or meisoindigo(Me)to inhibit NF-kB and Wnt/β-catenin/GSK3P respectively for 4 or 8 weeks.As compared with untreated diabetic rats,treatment with either PDTC or Me partly attenuated the myocardial hypertrophy and interstitial fibrosis,improved cardiac function,and exhibited reduction in inflammatory reaction.In addition,we found that inhibiting NF-κB and Wnt/β-catenin/GSK3β pathways could regulate glucose and lipid metabolism.The effects were associated with the decrease of NF-κB activity and the downregulation of some proinflammatory cytokines,including tumor necrosis factor-alpha(TNF-α)and interleukin(IL)-2.Our data suggested that the activities of NF-κB and Wnt/β-catenin/GSK3β pathways were both increased and inhibiting NF-κB and Wnt/β-catenin/GSK3β signaling pathways might improve myocardial injury in T1DM rats. 展开更多
关键词 type 1 diabetes mellitus diabetic cardiomyopathy NF-κB Wnt/β-catenin/GSK3β
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Integrating deep learning and logging data analytics for lithofacies classification and 3D modeling of tight sandstone reservoirs 被引量:2
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作者 jing-jing liu Jian-Chao liu 《Geoscience Frontiers》 SCIE CAS CSCD 2022年第1期350-363,共14页
The lithofacies classification is essential for oil and gas reservoir exploration and development.The traditional method of lithofacies classification is based on"core calibration logging"and the experience ... The lithofacies classification is essential for oil and gas reservoir exploration and development.The traditional method of lithofacies classification is based on"core calibration logging"and the experience of geologists.This approach has strong subjectivity,low efficiency,and high uncertainty.This uncertainty may be one of the key factors affecting the results of 3 D modeling of tight sandstone reservoirs.In recent years,deep learning,which is a cutting-edge artificial intelligence technology,has attracted attention from various fields.However,the study of deep-learning techniques in the field of lithofacies classification has not been sufficient.Therefore,this paper proposes a novel hybrid deep-learning model based on the efficient data feature-extraction ability of convolutional neural networks(CNN)and the excellent ability to describe time-dependent features of long short-term memory networks(LSTM)to conduct lithological facies-classification experiments.The results of a series of experiments show that the hybrid CNN-LSTM model had an average accuracy of 87.3%and the best classification effect compared to the CNN,LSTM or the three commonly used machine learning models(Support vector machine,random forest,and gradient boosting decision tree).In addition,the borderline synthetic minority oversampling technique(BSMOTE)is introduced to address the class-imbalance issue of raw data.The results show that processed data balance can significantly improve the accuracy of lithofacies classification.Beside that,based on the fine lithofacies constraints,the sequential indicator simulation method is used to establish a three-dimensional lithofacies model,which completes the fine description of the spatial distribution of tight sandstone reservoirs in the study area.According to this comprehensive analysis,the proposed CNN-LSTM model,which eliminates class imbalance,can be effectively applied to lithofacies classification,and is expected to improve the reality of the geological model for the tight sandstone reservoirs. 展开更多
关键词 Deep learning Convolutional neural networks LSTM Lithological-facies classification 3D modeling Class imbalance
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Clinical features of posterior microphthalmic and nanophthalmic eyes 被引量:2
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作者 jing-jing liu Yi-Ye Chen +1 位作者 Xiang Zhang Pei-Quan Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第11期1829-1834,共6页
AIM: To clinically differentiate nanophthalmos(NO) and posterior microphthalmos(PM) and to explore the mechanisms related to papillomacular folds(PMF).METHODS: Medical records of 34 unrelated patients with mic... AIM: To clinically differentiate nanophthalmos(NO) and posterior microphthalmos(PM) and to explore the mechanisms related to papillomacular folds(PMF).METHODS: Medical records of 34 unrelated patients with microphthalmos(54 eyes) from April 2009 to October 2017 were retrospectively reviewed.RESULTS: Fourteen eyes of 7 unrelated patients with NO and PM were included in the study. The presenting age of the NO cohort was significantly higher compared with the PM cohort(NO: 27±16 y; PM: 3.7±0.6 y). PMF was more likely to occur in cases with PM than in NO(25% in NO, 100% in PM). The anatomic features of PMF from optical coherence tomography(OCT) included: ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and outer nuclear layer. In eyes without an apparent PMF(these were all NO eyes), rudimentary fovea without a foveal pit was noted. Four eyes that were NO developed angle closure glaucoma. Three NO eyes developed exudative retinal detachment and were successfully treated with lamellar sclerectomy.CONCLUSION: Posterior segment changes are pervasive both in PM and NO. Complications like angle closure glaucoma and exudative retinal detachment are likely to occur in eyes with NO but not with PM. Detailed OCT analysis found that PMF was partially a neural retinal issue, suggesting that redundancy of retinal issues involved only inner retinal layers. 展开更多
关键词 NANOPHTHALMOS non-rhegmatogenous retinal detachment optical coherence tomography papillomacular folds posterior microphthalmos rudimentary fovea
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Effectiveness of combining manual external defibrillator and automated external defibrillator training for third-year nurse students 被引量:1
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作者 jing-jing liu Li Gui +4 位作者 Zhuo-Min Chen Kai-Yun Xu Ying Li Jing Zhang Ling-Jun Zhou 《International Journal of Nursing Sciences》 2015年第1期105-109,共5页
Purpose:To assess the effectiveness of automated external defibrillator(AED)and manual external defibrillator(MED)training for third-year nurse students.Methods:We conducted post-demonstration and post-practice evalua... Purpose:To assess the effectiveness of automated external defibrillator(AED)and manual external defibrillator(MED)training for third-year nurse students.Methods:We conducted post-demonstration and post-practice evaluation for MED defibrillation,and pre-training,post-demonstration,and post-practice evaluation for AED defibrillation.Results:Following MED training,time and confidence to defibrillate were improved significantly post-practice(p<0.001,p<0.001,respectively).In post-demonstration and postpractice evaluation,most students placed electrodes correctly(84.21%vs.80.70%),cleared before defibrillation(75.44%vs.89.47%),and performed cardiopulmonary resuscitation immediately after defibrillation(81.81%vs.94.44%);the evaluations were not statistically different(p=0.806,p=0.094,p=0.198,respectively).For AED training,time and confidence to defibrillate post-demonstration and post-practice were significantly improved(p<0.001 vs.p<0.001;p<0.001 vs.p<0.001,respectively)compared to that of pre-training;there was no obvious difference between the post-demonstration and postpractice evaluation(p=0.235,=0.346,respectively).Post-AED demonstration,most students could place electrodes correctly(85.96%),clear(91.23%),and perform CPR immediately after defibrillation(85.96%),which remained at a high level post-practice(94.74%,85.96%,82.46%,respectively);there was no significant difference between the two evaluations(p=0.203,p=0.557,p=0.776,respectively).Conclusion:Combining MED and AED defibrillation training is effective and feasible for third-year nurse students.Minimal training is effective for AED,while MED requires additional practice. 展开更多
关键词 Automated external defibrillator(AED) Manual external defibrillator(MED) Minimal AED training Nurse students TRAINING
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闭环肌松注射系统T1模式在小儿腹腔镜阑尾切除术中的应用 被引量:1
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作者 刘静静 吴小乐 刘苏 《中国内镜杂志》 2022年第10期24-29,共6页
目的 探究闭环肌松注射系统T1模式在小儿腹腔镜阑尾切除术中应用的临床效果及安全性。方法 选取2016年1月-2017年1月徐州医科大学附属徐州市儿童医院行腹腔镜阑尾切除术的患儿70例。按照随机数表法将患儿分为实验组和对照组,实验组采用... 目的 探究闭环肌松注射系统T1模式在小儿腹腔镜阑尾切除术中应用的临床效果及安全性。方法 选取2016年1月-2017年1月徐州医科大学附属徐州市儿童医院行腹腔镜阑尾切除术的患儿70例。按照随机数表法将患儿分为实验组和对照组,实验组采用闭环肌松注射系统T1模式给予顺式阿曲库铵,对照组采用肌松恒速注射系统给予顺式阿曲库铵,比较两组患儿手术相关指标、血流动力学指标和肌松监测指标。结果 两组患儿麻醉时间、手术时间和手术过程中体动次数比较,差异均无统计学意义(P> 0.05);两组患儿麻醉诱导前20 min、插管时、插管后3 min、拔管时和拔管后30 min的平均动脉压(MAP)、心率(HR)和经皮动脉血氧饱和度(SpO_(2))比较,差异均无统计学意义(P> 0.05);实验组恢复指数、4个成串刺激比值(TOFr) 75和TOFr90明显短于对照组,差异均有统计学意义(P <0.05);实验组第1次睁眼时间、持续抬头5 s时间、拔管时间明显短于对照组,差异均有统计学意义(P <0.05);实验组顺式阿曲库铵使用总量明显少于对照组(P <0.05)。两组患儿均未出现明显的不良反应。结论 在小儿腹腔镜阑尾切除术中应用闭环肌松注射系统T1模式安全且有效,能明显减少肌松残余,值得临床推广应用。 展开更多
关键词 闭环肌松注射系统T1模式 顺式阿曲库铵 学龄前儿童 肌松残余
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Strongly screened electron capture rates of chromium isotopes in presupernova evolution 被引量:1
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作者 jing-jing liu Qiu-He Peng +2 位作者 Liang-Huan Hao Xiao-Ping Kang Dong-Mei liu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2017年第10期91-96,共6页
Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of Shell-Model Monte Carlo and random phase approximation theory, we investigate the c... Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of Shell-Model Monte Carlo and random phase approximation theory, we investigate the capture rates of chromium isotopes with strong electron screening according to the linear response theory screening model. Strong screening rates can decrease by about 40.43% (e.g., for 6Cr at T9 = 3.44, Ye = 0.43). Our conclusions may be helpful to researches on supernova explosions and related numerical simulation methods. 展开更多
关键词 nuclear reactions -- electron capture -- supernovae
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Protective antitumor immunity induced by tumor cell lysates conjugated with diphtheria toxin and adjuvant epitope in mouse breast tumor models
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作者 Ze-Yu Wang Yun Xing +10 位作者 Bin liu Lei Lu Xiao Huang Chi-Yu Ge Wen-Jun Yao Mao-Lei Xu Zhen-Qiu Gao Rong-Yue Cao Jie Wu Tai-Ming Li jing-jing liu 《Chinese Journal of Cancer》 SCIE CAS CSCD 2012年第6期295-305,共11页
Cancer cell vaccine-based immunotherapy has received increasing interest in many clinical trials involving patients with breast cancer. Combining with appropriate adjuvants can enhance the weak immunogenic properties ... Cancer cell vaccine-based immunotherapy has received increasing interest in many clinical trials involving patients with breast cancer. Combining with appropriate adjuvants can enhance the weak immunogenic properties of tumor cell lysates (TCL). In this study, diphtheria toxin (DT) and two tandem repeats of mycobacterial heat shock protein 70 (mHSP70) fragment 407-426 (M2) were conjugated to TCL with glutaraldehyde, and the constructed cancer cell vaccine was named DT-TCL-M2. Subcutaneous injection of DT-TCL-M2in mice effectively elicited tumor-specific polyclonal immune responses, including humoral and cellular immune responses. High levels of antibodies against TCL were detected in the serum of immunized mice with ELISA and verified with Western blot analyses. The splenocytes from immunized mice showed potent cytotoxicity on Ehrlich ascites carcinoma cells. Moreover, the protective antitumor immunity induced by DT-TCL-M2 inhibited tumor growth in a mouse breast tumor model. DT-TCL-M2 also attenuated tumor-induced angiogenesis and slowed tumor growth in a mouse intradermal tumor model. These findings demonstrate that TCL conjugated with appropriate adjuvants induced effective antitumor immunity in vivo. Improvements in potency could further make cancer cell vaccines a useful and safe method for preventing cancer recurrence after resection. 展开更多
关键词 肿瘤免疫 免疫小鼠 肿瘤模型 细胞裂解 白喉毒素 乳腺癌 诱导 共轭
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Chiral separation of bavachinin in Fructus Psoraleae and rat plasma by liquid chromatography using permethylated-b-CD as a chiral selector
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作者 jing-jing liu Juan Zhang Zi-Lin Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS 2013年第5期349-353,共5页
A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation ... A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation and detection conditions of HPLC were optimized. Chiral bavachinin were separated with the mobile phase of methanol and water (70:30, v/v) at a flow rate of 1.0 mL/min. The linear ranges were in the range of 20-1000 μg/mL. The detection limits were tested as 4 ng/mL and 6 ng/mL for (+)-bavachinin and (-)-bavachinin, respectively. The method has been applied to analyze chiral bavachinin in rat plasma. HPLC-MS method was used to test the accuracy. 展开更多
关键词 Bavachinin Fructus Psoraleae HPLC–MS HPLC-UV Rat plasma
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An effective snakebite first aid training method for medics in the Chinese troops: a RCT
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作者 Chen Qiu Xiao-Feng Qiu +2 位作者 jing-jing liu Yi-Xin Wang Li Gui 《Military Medical Research》 SCIE CAS CSCD 2020年第1期55-62,共8页
Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Th... Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Therefore,this study aimed to explore the impact of the Standard Operation Procedure(SOP)and checklist on Chinese military medics’ability to manage snakebite first aid.Methods:This study was a prospective single-blind randomized controlled trial conducted in a military medical university of China from May to June 2017.A questionnaire-based survey was performed to collect the participants’socio-demographic profiles before the baseline measurement.During the baseline measurement,participants were requested to provide corresponding first aid that was responsive to the simulative situation portrayed by the standardized patients(SPs)and the evaluators then scored their performances according to a checklist for snakebite first aid scoring table.After the baseline measurement,they were randomly assigned to one of three intervention groups after stratification according to their baseline performance scores:group A received a self-learning course with textbooks(n=27),group B received a self-learning training on the SOP and checklist(n=27)and group C was engaged in an interactive discussion panel regarding the SOP and checklist(n=26).After the interventions,participants received outcome measurements about snakebite first aid key points capability from the same evaluator and SP for each group to avoid observational error.The reviewers were blinded about the grouping in the trial.Results:The baseline measurement yielded no significant difference(H=1.647,P=0.439)among the three groups.The post-intervention scores were higher than the pre-intervention scores for all three(A,B and C)groups(P=0.008,P<0.001 and P<0.001,respectively).There was significant difference of the post-intervention scores among the three groups(F=8.841,P<0.001).Both post-intervention scores of group B and group C were higher than that of group A(P<0.001 and P=0.001,respectively),but no difference was found between group B and C(P=0.695).The acceptance questionnaire score of SOP and checklist was mostly very satisfied,as the final scores of group B and group C were 4.62±0.61 and 4.82±0.45,respectively.Conclusions:In this study,the implementation of an SOP and checklist for snakebite first aid was shown to update and improve first aid treatment concepts in military medics.These intervention methods played an important role in improving the medics’cognition and understanding of snakebite first aid.Therefore,this finding suggests that SOP and checklist training should be further implemented in Chinese troops for snakebite care. 展开更多
关键词 SNAKEBITE Standard operation procedure(SOP) CHECKLIST Medic TRAINING
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Neutrino energy spectrum and electron capture of Nuclides^(56))Fe,^(56)Co,^(56)Ni,^(56)Mn,^(56)Cr and^(56)V in stellar interiors
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作者 jing-jing liu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第8期971-978,共8页
Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in... Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in presupemova surroundings. The results show that the EC rates are affected greatly at different densities and temperatures. The rates increase greatly and even exceed six orders of magnitude at lower temperature. On the other hand, the NES is very sensitive to stellar temperature and electron energy. The higher the temperature and the lower the electron energy, the larger the influence on NES is. For example, the maxima of NES in the ground state are 9.02, 160, 80, 24.01, 0.44, 1.42 me c^2 for ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V respectively at ρ7 = 10.7, Ye = 0.45 and T9 = 15. Furthermore, the influence on NES due to EC for different nuclei has some otherness because of different Qo-values. For example, the spectrum of ^56Co shows a double bump structure. 展开更多
关键词 physical data and processes neutrinos nuclear reactions -- stars super- novae -- stars evolution
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Beta decay of nuclides ^(56)Fe,^(62)Ni,^(64)Ni and ^(68)Ni in the crust of magnetars
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作者 jing-jing liu Xiao-Ping Kang +4 位作者 Liang-Huan Hao Hao Feng Dong-Mei liu Chang-Wei Li Xiang-Ming Zeng 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2016年第11期71-80,共10页
By introducing the Dirac δ-function and Pauli exclusion principle in the presence of superstrong magnetic fields (SMFs), we investigate the influence of SMFs on beta decay and the change rates of electron fraction ... By introducing the Dirac δ-function and Pauli exclusion principle in the presence of superstrong magnetic fields (SMFs), we investigate the influence of SMFs on beta decay and the change rates of electron fraction (CREF) of nuclides 56Fe, 62Ni, 64Ni and 6SNi in magnetars, which are powered by magnetic field energy. We find that the magnetic fields have a great influence on the beta decay rates, and the beta decay rates can decrease by more than six orders of magnitude in the presence of SMFs. The CREF also decreases by more than seven orders of magnitude in the presence of SMFs. 展开更多
关键词 physical data and processes: nuclear reactions NUCLEOSYNTHESIS abundances -- stars: neutron-- stars: magnetic fields
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