The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical industry.Moreover,flammable and explosive hydrogen as the common hydrogen source o...The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical industry.Moreover,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial production.Herein,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton source.Before the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen production.Among them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple cycles.This“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions.展开更多
BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact...BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact of task-oriented training based on acupuncture therapy on upper extremity function in patients with early stroke.METHODS Patients with early stroke hemiplegia who visited our hospital between January 2021 and October 2022 were divided into a control group and an observation group,each with 50 cases.The control group underwent head acupuncture plus routine upper limb rehabilitation training(acupuncture therapy).In addition to acupuncture and rehabilitation,the observation group underwent upper limb task-oriented training(30 min).Each group underwent treatment 5 d/wk for 4 wk.Upper extremity function was assessed in both groups using the Fugl-Meyer Assessment-Upper Extremity(FMA-UE),Wolf Motor Function Rating Scale(WMFT),modified Barthel Index(MBI),and Canadian Occupational Performance Measure(COPM).Quality of life was evaluated using the Short-Form 36-Item Health Survey(SF-36).Clinical efficacy of the interventions was also evaluated.RESULTS Before intervention,no significant differences were observed in the FMA-UE,MBI,and WMFT scores between the two groups(P>0.05).After intervention,the FMA-UE,WMFT,MBI,COPM-Functional Mobility and Satisfaction,and SF-36 scores increased in both groups(P<0.05),with even higher scores in the observation group(P<0.05).The observation group also obtained a higher total effective rate than the control group(P<0.05).CONCLUSION Task-oriented training based on acupuncture rehabilitation significantly enhanced upper extremity mobility,quality of life,and clinical efficacy in patients with early stroke.展开更多
Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-...Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-section.We find that a strong suppression controls the monopole catalysis of nucleon decay by the correction factor.The maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),respectively.The luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation.展开更多
BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and vitamins.AIM To investigate the recovery of gastrointestinal function in patients af...BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and vitamins.AIM To investigate the recovery of gastrointestinal function in patients after hepato-biliary surgery and identify effective rehabilitation measures.METHODS A total of 200 patients who underwent hepatobiliary surgery in our hospital in 2022 were selected as the study subjects.They were divided into a control group and a study group based on the extent of the surgery,with 100 patients in each group.The control group received routine treatment,while the study group re-ceived targeted interventions,including early enteral nutrition support,drinking water before gas discharge,and large bowel enema,to promote postoperative gastrointestinal function recovery.The recovery of gastrointestinal function was compared between the two groups.RESULTS Compared with the control group,patients in the study group had better recovery of bowel sounds and less accumulation of fluids in the liver bed and gallbladder fossa(P<0.05).They also had shorter time to gas discharge and first meal(P<0.05),higher overall effective rate of gastrointestinal function recovery(P<0.05),and lower incidence of postoperative complications(P<0.05).CONCLUSION Targeted nursing interventions(early nutritional support,drinking water before gas discharge,and enema)can effectively promote gastrointestinal function recovery in patients undergoing hepatobiliary surgery and reduce the incidence of complications,which is worthy of promotion.展开更多
A 1.7-at.%Er:CaF_(2)crystal was synthesized by temperature gradient method.The Er:CaF_(2)crystal was applied in acousto-optically Q-switched laser at mid-infrared region for the first time.Using a Te O_(2)-based cryst...A 1.7-at.%Er:CaF_(2)crystal was synthesized by temperature gradient method.The Er:CaF_(2)crystal was applied in acousto-optically Q-switched laser at mid-infrared region for the first time.Using a Te O_(2)-based crystal as Q-switcher,we obtained a laser diode(LD)end-pumped Er:CaF_(2)laser with the highest single pulse energy up to 0.49 mJ and maximum peak power of 0.56 kW under 6.34-W absorbed pump power.The implication of these results is that the low-doped Er:CaF_(2)crystal exhibits promising optical properties in solid-state lasers.展开更多
AIM To evaluate a 3 D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer. METHODS A retrospective analysis of our database was performed, and a total of 25 patients w...AIM To evaluate a 3 D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer. METHODS A retrospective analysis of our database was performed, and a total of 25 patients with pancreatic cancer who underwent iodine-125 seed implantation between January 2014 and November 2017 were analyzed. Of these, 12 implantations were assisted by a 3 D-printed coplanar template(group A), and 13 implantations performed freehand were selected as a control group(group B). A 3 D coplanar template was designed and printed according to a preoperative CT scan and treatment planning system. The iodine-125 seeds were then implanted using the template as a guide. Dosimetric verification was performed after implantation. Pre-and postoperative D90, V100, and V150 were calculated. The success rate of iodine-125 seed implantation, dosimetric parameters, and complications were analyzed and compared between the two groups.RESULTS Iodine-125 seed implantation was successfully performed in both groups. In group A, the median pre-and postoperative D90 values were 155.32 ± 8.05 Gy and 154.82 ± 16.43 Gy, respectively; the difference between these values was minimal and not statistically significant(P > 0.05). Postoperative V100 and V150 were 91.05% ± 4.06% and 64.54% ± 13.40%, respectively, which met the treatment requirement. A better dosimetric parameter was observed in group A than in group B, and the difference was statistically significant(V100: 91.05% ± 4.06% vs 72.91% ± 13.78%, P < 0.05). No major procedure-related complications were observed in either group. For group A, mild hemorrhage was observed in 1 patient with a peritoneal local hematoma due to mesenteric vein damage from the iodine-125 seed implantation needle. The hematoma resolved spontaneously without treatment. Postoperative blood amylase levels remained within the normal range for all patients.CONCLUSION A 3 D-printed coplanar template appears to be a safe and effective iodine-125 seed implantation guidance tool to improve implantation accuracy and optimize dosimetric distribution.展开更多
AIM:To introduce a modified technique of internal limiting membrane(ILM)centripetal dragging and peeling to treat idiopathic macular hole(IMH)and to observe the ILM-retina adhesive forces.METHODS:Twenty-six consecutiv...AIM:To introduce a modified technique of internal limiting membrane(ILM)centripetal dragging and peeling to treat idiopathic macular hole(IMH)and to observe the ILM-retina adhesive forces.METHODS:Twenty-six consecutive patients with stage 3 to 4 IMH and followed up at least six months were enrolled.All patients underwent complete par plana vitrectomy,ILM dragging and peeling,fluid and gas exchange,15%C3 F8 tamponade and 2-week prone position.The best corrected visual acuity,macular hole evaluation by optical coherence tomography,and complications were evaluated.RESULTS:The mean diameter of IMH was 524±148μm(range:201-683μm),with 21 cases(80.8%)greater than 400μm.ILM dragging and peeling were successfully performed in all cases.Most of the ILM-retina adhesive forces are severe(42.3%,11/26),followed by mild(38.5%,10/26),and moderate(19.2%,5/26).The mean follow-up duration was 21.2±6.1 mo.The IMH was closed in 25(96.3%)eyes.Visual acuity(logMAR)improved significantly from 1.2±0.6 preoperatively to 0.7±0.5 postoperatively(P<0.001).CONCLUSION:Preexisting ILM-retina adhesive force is found in IMH patients.With assistance of this force,this modified technique may help to release the IMH edges and improve the closure rate of large IMH.展开更多
Type 1 diabetes mellitus(T1DM)is associated with an increased risk of diabetic cardiomyopathy(DCM).Nuclear factor kappa B(NF-kB)and Wnt/β-catenin/GSK3p have been demonstrated to play pathogenic roles in diabetes.In t...Type 1 diabetes mellitus(T1DM)is associated with an increased risk of diabetic cardiomyopathy(DCM).Nuclear factor kappa B(NF-kB)and Wnt/β-catenin/GSK3p have been demonstrated to play pathogenic roles in diabetes.In this study,we evaluated the roles of these two pathways in T1 DM-induced cardiomyopathy in rats.Streptozotocin(STZ)-induced type 1 diabetic rats were treated with pyrrolidine dithiocarbamate(PDTC)or meisoindigo(Me)to inhibit NF-kB and Wnt/β-catenin/GSK3P respectively for 4 or 8 weeks.As compared with untreated diabetic rats,treatment with either PDTC or Me partly attenuated the myocardial hypertrophy and interstitial fibrosis,improved cardiac function,and exhibited reduction in inflammatory reaction.In addition,we found that inhibiting NF-κB and Wnt/β-catenin/GSK3β pathways could regulate glucose and lipid metabolism.The effects were associated with the decrease of NF-κB activity and the downregulation of some proinflammatory cytokines,including tumor necrosis factor-alpha(TNF-α)and interleukin(IL)-2.Our data suggested that the activities of NF-κB and Wnt/β-catenin/GSK3β pathways were both increased and inhibiting NF-κB and Wnt/β-catenin/GSK3β signaling pathways might improve myocardial injury in T1DM rats.展开更多
The lithofacies classification is essential for oil and gas reservoir exploration and development.The traditional method of lithofacies classification is based on"core calibration logging"and the experience ...The lithofacies classification is essential for oil and gas reservoir exploration and development.The traditional method of lithofacies classification is based on"core calibration logging"and the experience of geologists.This approach has strong subjectivity,low efficiency,and high uncertainty.This uncertainty may be one of the key factors affecting the results of 3 D modeling of tight sandstone reservoirs.In recent years,deep learning,which is a cutting-edge artificial intelligence technology,has attracted attention from various fields.However,the study of deep-learning techniques in the field of lithofacies classification has not been sufficient.Therefore,this paper proposes a novel hybrid deep-learning model based on the efficient data feature-extraction ability of convolutional neural networks(CNN)and the excellent ability to describe time-dependent features of long short-term memory networks(LSTM)to conduct lithological facies-classification experiments.The results of a series of experiments show that the hybrid CNN-LSTM model had an average accuracy of 87.3%and the best classification effect compared to the CNN,LSTM or the three commonly used machine learning models(Support vector machine,random forest,and gradient boosting decision tree).In addition,the borderline synthetic minority oversampling technique(BSMOTE)is introduced to address the class-imbalance issue of raw data.The results show that processed data balance can significantly improve the accuracy of lithofacies classification.Beside that,based on the fine lithofacies constraints,the sequential indicator simulation method is used to establish a three-dimensional lithofacies model,which completes the fine description of the spatial distribution of tight sandstone reservoirs in the study area.According to this comprehensive analysis,the proposed CNN-LSTM model,which eliminates class imbalance,can be effectively applied to lithofacies classification,and is expected to improve the reality of the geological model for the tight sandstone reservoirs.展开更多
AIM: To clinically differentiate nanophthalmos(NO) and posterior microphthalmos(PM) and to explore the mechanisms related to papillomacular folds(PMF).METHODS: Medical records of 34 unrelated patients with mic...AIM: To clinically differentiate nanophthalmos(NO) and posterior microphthalmos(PM) and to explore the mechanisms related to papillomacular folds(PMF).METHODS: Medical records of 34 unrelated patients with microphthalmos(54 eyes) from April 2009 to October 2017 were retrospectively reviewed.RESULTS: Fourteen eyes of 7 unrelated patients with NO and PM were included in the study. The presenting age of the NO cohort was significantly higher compared with the PM cohort(NO: 27±16 y; PM: 3.7±0.6 y). PMF was more likely to occur in cases with PM than in NO(25% in NO, 100% in PM). The anatomic features of PMF from optical coherence tomography(OCT) included: ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and outer nuclear layer. In eyes without an apparent PMF(these were all NO eyes), rudimentary fovea without a foveal pit was noted. Four eyes that were NO developed angle closure glaucoma. Three NO eyes developed exudative retinal detachment and were successfully treated with lamellar sclerectomy.CONCLUSION: Posterior segment changes are pervasive both in PM and NO. Complications like angle closure glaucoma and exudative retinal detachment are likely to occur in eyes with NO but not with PM. Detailed OCT analysis found that PMF was partially a neural retinal issue, suggesting that redundancy of retinal issues involved only inner retinal layers.展开更多
Purpose:To assess the effectiveness of automated external defibrillator(AED)and manual external defibrillator(MED)training for third-year nurse students.Methods:We conducted post-demonstration and post-practice evalua...Purpose:To assess the effectiveness of automated external defibrillator(AED)and manual external defibrillator(MED)training for third-year nurse students.Methods:We conducted post-demonstration and post-practice evaluation for MED defibrillation,and pre-training,post-demonstration,and post-practice evaluation for AED defibrillation.Results:Following MED training,time and confidence to defibrillate were improved significantly post-practice(p<0.001,p<0.001,respectively).In post-demonstration and postpractice evaluation,most students placed electrodes correctly(84.21%vs.80.70%),cleared before defibrillation(75.44%vs.89.47%),and performed cardiopulmonary resuscitation immediately after defibrillation(81.81%vs.94.44%);the evaluations were not statistically different(p=0.806,p=0.094,p=0.198,respectively).For AED training,time and confidence to defibrillate post-demonstration and post-practice were significantly improved(p<0.001 vs.p<0.001;p<0.001 vs.p<0.001,respectively)compared to that of pre-training;there was no obvious difference between the post-demonstration and postpractice evaluation(p=0.235,=0.346,respectively).Post-AED demonstration,most students could place electrodes correctly(85.96%),clear(91.23%),and perform CPR immediately after defibrillation(85.96%),which remained at a high level post-practice(94.74%,85.96%,82.46%,respectively);there was no significant difference between the two evaluations(p=0.203,p=0.557,p=0.776,respectively).Conclusion:Combining MED and AED defibrillation training is effective and feasible for third-year nurse students.Minimal training is effective for AED,while MED requires additional practice.展开更多
Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of Shell-Model Monte Carlo and random phase approximation theory, we investigate the c...Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of Shell-Model Monte Carlo and random phase approximation theory, we investigate the capture rates of chromium isotopes with strong electron screening according to the linear response theory screening model. Strong screening rates can decrease by about 40.43% (e.g., for 6Cr at T9 = 3.44, Ye = 0.43). Our conclusions may be helpful to researches on supernova explosions and related numerical simulation methods.展开更多
Cancer cell vaccine-based immunotherapy has received increasing interest in many clinical trials involving patients with breast cancer. Combining with appropriate adjuvants can enhance the weak immunogenic properties ...Cancer cell vaccine-based immunotherapy has received increasing interest in many clinical trials involving patients with breast cancer. Combining with appropriate adjuvants can enhance the weak immunogenic properties of tumor cell lysates (TCL). In this study, diphtheria toxin (DT) and two tandem repeats of mycobacterial heat shock protein 70 (mHSP70) fragment 407-426 (M2) were conjugated to TCL with glutaraldehyde, and the constructed cancer cell vaccine was named DT-TCL-M2. Subcutaneous injection of DT-TCL-M2in mice effectively elicited tumor-specific polyclonal immune responses, including humoral and cellular immune responses. High levels of antibodies against TCL were detected in the serum of immunized mice with ELISA and verified with Western blot analyses. The splenocytes from immunized mice showed potent cytotoxicity on Ehrlich ascites carcinoma cells. Moreover, the protective antitumor immunity induced by DT-TCL-M2 inhibited tumor growth in a mouse breast tumor model. DT-TCL-M2 also attenuated tumor-induced angiogenesis and slowed tumor growth in a mouse intradermal tumor model. These findings demonstrate that TCL conjugated with appropriate adjuvants induced effective antitumor immunity in vivo. Improvements in potency could further make cancer cell vaccines a useful and safe method for preventing cancer recurrence after resection.展开更多
A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation ...A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation and detection conditions of HPLC were optimized. Chiral bavachinin were separated with the mobile phase of methanol and water (70:30, v/v) at a flow rate of 1.0 mL/min. The linear ranges were in the range of 20-1000 μg/mL. The detection limits were tested as 4 ng/mL and 6 ng/mL for (+)-bavachinin and (-)-bavachinin, respectively. The method has been applied to analyze chiral bavachinin in rat plasma. HPLC-MS method was used to test the accuracy.展开更多
Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Th...Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Therefore,this study aimed to explore the impact of the Standard Operation Procedure(SOP)and checklist on Chinese military medics’ability to manage snakebite first aid.Methods:This study was a prospective single-blind randomized controlled trial conducted in a military medical university of China from May to June 2017.A questionnaire-based survey was performed to collect the participants’socio-demographic profiles before the baseline measurement.During the baseline measurement,participants were requested to provide corresponding first aid that was responsive to the simulative situation portrayed by the standardized patients(SPs)and the evaluators then scored their performances according to a checklist for snakebite first aid scoring table.After the baseline measurement,they were randomly assigned to one of three intervention groups after stratification according to their baseline performance scores:group A received a self-learning course with textbooks(n=27),group B received a self-learning training on the SOP and checklist(n=27)and group C was engaged in an interactive discussion panel regarding the SOP and checklist(n=26).After the interventions,participants received outcome measurements about snakebite first aid key points capability from the same evaluator and SP for each group to avoid observational error.The reviewers were blinded about the grouping in the trial.Results:The baseline measurement yielded no significant difference(H=1.647,P=0.439)among the three groups.The post-intervention scores were higher than the pre-intervention scores for all three(A,B and C)groups(P=0.008,P<0.001 and P<0.001,respectively).There was significant difference of the post-intervention scores among the three groups(F=8.841,P<0.001).Both post-intervention scores of group B and group C were higher than that of group A(P<0.001 and P=0.001,respectively),but no difference was found between group B and C(P=0.695).The acceptance questionnaire score of SOP and checklist was mostly very satisfied,as the final scores of group B and group C were 4.62±0.61 and 4.82±0.45,respectively.Conclusions:In this study,the implementation of an SOP and checklist for snakebite first aid was shown to update and improve first aid treatment concepts in military medics.These intervention methods played an important role in improving the medics’cognition and understanding of snakebite first aid.Therefore,this finding suggests that SOP and checklist training should be further implemented in Chinese troops for snakebite care.展开更多
Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in...Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in presupemova surroundings. The results show that the EC rates are affected greatly at different densities and temperatures. The rates increase greatly and even exceed six orders of magnitude at lower temperature. On the other hand, the NES is very sensitive to stellar temperature and electron energy. The higher the temperature and the lower the electron energy, the larger the influence on NES is. For example, the maxima of NES in the ground state are 9.02, 160, 80, 24.01, 0.44, 1.42 me c^2 for ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V respectively at ρ7 = 10.7, Ye = 0.45 and T9 = 15. Furthermore, the influence on NES due to EC for different nuclei has some otherness because of different Qo-values. For example, the spectrum of ^56Co shows a double bump structure.展开更多
By introducing the Dirac δ-function and Pauli exclusion principle in the presence of superstrong magnetic fields (SMFs), we investigate the influence of SMFs on beta decay and the change rates of electron fraction ...By introducing the Dirac δ-function and Pauli exclusion principle in the presence of superstrong magnetic fields (SMFs), we investigate the influence of SMFs on beta decay and the change rates of electron fraction (CREF) of nuclides 56Fe, 62Ni, 64Ni and 6SNi in magnetars, which are powered by magnetic field energy. We find that the magnetic fields have a great influence on the beta decay rates, and the beta decay rates can decrease by more than six orders of magnitude in the presence of SMFs. The CREF also decreases by more than seven orders of magnitude in the presence of SMFs.展开更多
基金supported by NSFC(Grant Nos.92061101,22271104,21871141,22225109,and 21901123)the Excellent Youth Foundation of Jiangsu Scientific Committee(BK20211593)+2 种基金the project funded by the China Postdoctoral Science Foundation(2018M630572)the Priority Academic Program Development of Jiangsu Higher Education Institutions,and the Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,the National Key Research and Development Project of China(Grant No.2021YFC2100100)the Natural Science Foundation of Jiangsu Province(Grant No.BK20190694)。
文摘The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical industry.Moreover,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial production.Herein,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton source.Before the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen production.Among them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple cycles.This“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions.
文摘BACKGROUND Eighty percent of stroke patients develop upper limb dysfunction,especially hand dysfunction,which has a very slow recovery,resulting in economic burden to families and society.AIM To investigate the impact of task-oriented training based on acupuncture therapy on upper extremity function in patients with early stroke.METHODS Patients with early stroke hemiplegia who visited our hospital between January 2021 and October 2022 were divided into a control group and an observation group,each with 50 cases.The control group underwent head acupuncture plus routine upper limb rehabilitation training(acupuncture therapy).In addition to acupuncture and rehabilitation,the observation group underwent upper limb task-oriented training(30 min).Each group underwent treatment 5 d/wk for 4 wk.Upper extremity function was assessed in both groups using the Fugl-Meyer Assessment-Upper Extremity(FMA-UE),Wolf Motor Function Rating Scale(WMFT),modified Barthel Index(MBI),and Canadian Occupational Performance Measure(COPM).Quality of life was evaluated using the Short-Form 36-Item Health Survey(SF-36).Clinical efficacy of the interventions was also evaluated.RESULTS Before intervention,no significant differences were observed in the FMA-UE,MBI,and WMFT scores between the two groups(P>0.05).After intervention,the FMA-UE,WMFT,MBI,COPM-Functional Mobility and Satisfaction,and SF-36 scores increased in both groups(P<0.05),with even higher scores in the observation group(P<0.05).The observation group also obtained a higher total effective rate than the control group(P<0.05).CONCLUSION Task-oriented training based on acupuncture rehabilitation significantly enhanced upper extremity mobility,quality of life,and clinical efficacy in patients with early stroke.
基金supported in part by the National Natural Science Foundation of China(NSFC,grant Nos.11965010 and 11565020)the foundation for high-level talents program of Hainan basic and applied basic research program(natural science)under grant 2019RC239+3 种基金the Natural Science Foundation of Hainan Province under grants 118MS071 and 114012the Counterpart Foundation of Sanya under grants 2016PT43 and 2019PT76the Special Foundation of Science and Technology Cooperation for Advanced Academy and Regional of Sanya under grant 2016YD28the Scientific Research Starting Foundation for 515 Talented Project of Hainan Tropical Ocean University under grant RHDRC201701。
文摘Twenty-five typical massive white dwarfs(WDs)are selected and the proton decay reaction catalyzed by magnetic monopoles(MMs)for these WDs is discussed.A velocity-dependent correction factor strongly affects the cross-section.We find that a strong suppression controls the monopole catalysis of nucleon decay by the correction factor.The maximum number of MMs is captured and the luminosity can be 2.235×10^(21)and 1.7859×10^(32)erg s^(-1)(e.g.,for the O+Ne core mass WD J055631.17+130639.78).The luminosities of most massive WDs agree well with the observations at relatively low temperatures(e.g.,T_(6)=0.1),but can be three and two orders of magnitude higher than those of the observations for model(Ⅰ)and(Ⅱ)at relatively high temperatures(e.g.,T_(6)=10),respectively.The luminosities of model(Ⅰ)are about one order of magnitude higher than those of model(Ⅱ).Since we consider the effect of the number of MMs captured on the mass–radius relation and the suppression of the proton decay by the correction factor,the study by model(Ⅱ)may be an improved estimation.
文摘BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and vitamins.AIM To investigate the recovery of gastrointestinal function in patients after hepato-biliary surgery and identify effective rehabilitation measures.METHODS A total of 200 patients who underwent hepatobiliary surgery in our hospital in 2022 were selected as the study subjects.They were divided into a control group and a study group based on the extent of the surgery,with 100 patients in each group.The control group received routine treatment,while the study group re-ceived targeted interventions,including early enteral nutrition support,drinking water before gas discharge,and large bowel enema,to promote postoperative gastrointestinal function recovery.The recovery of gastrointestinal function was compared between the two groups.RESULTS Compared with the control group,patients in the study group had better recovery of bowel sounds and less accumulation of fluids in the liver bed and gallbladder fossa(P<0.05).They also had shorter time to gas discharge and first meal(P<0.05),higher overall effective rate of gastrointestinal function recovery(P<0.05),and lower incidence of postoperative complications(P<0.05).CONCLUSION Targeted nursing interventions(early nutritional support,drinking water before gas discharge,and enema)can effectively promote gastrointestinal function recovery in patients undergoing hepatobiliary surgery and reduce the incidence of complications,which is worthy of promotion.
基金the National Natural Science Foundation of China(Grant Nos.11974220,61925508,61905265,and 12104271)the Natural Science Foundation of Shandong Province,China(Grant Nos.ZR2021LLZ008 and ZR2021QA030)+1 种基金the Fund from Science and Technology Commission of Shanghai Municipality(Grant No.20511107400)CAS Interdisciplinary Innovation Team(Grant No.JCTD-2019-12).
文摘A 1.7-at.%Er:CaF_(2)crystal was synthesized by temperature gradient method.The Er:CaF_(2)crystal was applied in acousto-optically Q-switched laser at mid-infrared region for the first time.Using a Te O_(2)-based crystal as Q-switcher,we obtained a laser diode(LD)end-pumped Er:CaF_(2)laser with the highest single pulse energy up to 0.49 mJ and maximum peak power of 0.56 kW under 6.34-W absorbed pump power.The implication of these results is that the low-doped Er:CaF_(2)crystal exhibits promising optical properties in solid-state lasers.
基金Supported by the National Natural Science Foundation of China,No.81771949 and No.81471808the Project of Medical Key Specialty of Shanghai Municipality,No.ZK2015A22the Science and Technology Commission of Shanghai Municipality,No.18411968600
文摘AIM To evaluate a 3 D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer. METHODS A retrospective analysis of our database was performed, and a total of 25 patients with pancreatic cancer who underwent iodine-125 seed implantation between January 2014 and November 2017 were analyzed. Of these, 12 implantations were assisted by a 3 D-printed coplanar template(group A), and 13 implantations performed freehand were selected as a control group(group B). A 3 D coplanar template was designed and printed according to a preoperative CT scan and treatment planning system. The iodine-125 seeds were then implanted using the template as a guide. Dosimetric verification was performed after implantation. Pre-and postoperative D90, V100, and V150 were calculated. The success rate of iodine-125 seed implantation, dosimetric parameters, and complications were analyzed and compared between the two groups.RESULTS Iodine-125 seed implantation was successfully performed in both groups. In group A, the median pre-and postoperative D90 values were 155.32 ± 8.05 Gy and 154.82 ± 16.43 Gy, respectively; the difference between these values was minimal and not statistically significant(P > 0.05). Postoperative V100 and V150 were 91.05% ± 4.06% and 64.54% ± 13.40%, respectively, which met the treatment requirement. A better dosimetric parameter was observed in group A than in group B, and the difference was statistically significant(V100: 91.05% ± 4.06% vs 72.91% ± 13.78%, P < 0.05). No major procedure-related complications were observed in either group. For group A, mild hemorrhage was observed in 1 patient with a peritoneal local hematoma due to mesenteric vein damage from the iodine-125 seed implantation needle. The hematoma resolved spontaneously without treatment. Postoperative blood amylase levels remained within the normal range for all patients.CONCLUSION A 3 D-printed coplanar template appears to be a safe and effective iodine-125 seed implantation guidance tool to improve implantation accuracy and optimize dosimetric distribution.
基金Supported by the National Natural Science Foundation of China(No.81470642No.81770964)the Science and Technology Commission of Shanghai Municipality(No.17411952900)。
文摘AIM:To introduce a modified technique of internal limiting membrane(ILM)centripetal dragging and peeling to treat idiopathic macular hole(IMH)and to observe the ILM-retina adhesive forces.METHODS:Twenty-six consecutive patients with stage 3 to 4 IMH and followed up at least six months were enrolled.All patients underwent complete par plana vitrectomy,ILM dragging and peeling,fluid and gas exchange,15%C3 F8 tamponade and 2-week prone position.The best corrected visual acuity,macular hole evaluation by optical coherence tomography,and complications were evaluated.RESULTS:The mean diameter of IMH was 524±148μm(range:201-683μm),with 21 cases(80.8%)greater than 400μm.ILM dragging and peeling were successfully performed in all cases.Most of the ILM-retina adhesive forces are severe(42.3%,11/26),followed by mild(38.5%,10/26),and moderate(19.2%,5/26).The mean follow-up duration was 21.2±6.1 mo.The IMH was closed in 25(96.3%)eyes.Visual acuity(logMAR)improved significantly from 1.2±0.6 preoperatively to 0.7±0.5 postoperatively(P<0.001).CONCLUSION:Preexisting ILM-retina adhesive force is found in IMH patients.With assistance of this force,this modified technique may help to release the IMH edges and improve the closure rate of large IMH.
基金the Research Award Fund for Outstanding Young Scientists Plan in Shandong Province of China(No.BS2013SW008)the Innovation Project of Shandong Academy of Medical Sciences.
文摘Type 1 diabetes mellitus(T1DM)is associated with an increased risk of diabetic cardiomyopathy(DCM).Nuclear factor kappa B(NF-kB)and Wnt/β-catenin/GSK3p have been demonstrated to play pathogenic roles in diabetes.In this study,we evaluated the roles of these two pathways in T1 DM-induced cardiomyopathy in rats.Streptozotocin(STZ)-induced type 1 diabetic rats were treated with pyrrolidine dithiocarbamate(PDTC)or meisoindigo(Me)to inhibit NF-kB and Wnt/β-catenin/GSK3P respectively for 4 or 8 weeks.As compared with untreated diabetic rats,treatment with either PDTC or Me partly attenuated the myocardial hypertrophy and interstitial fibrosis,improved cardiac function,and exhibited reduction in inflammatory reaction.In addition,we found that inhibiting NF-κB and Wnt/β-catenin/GSK3β pathways could regulate glucose and lipid metabolism.The effects were associated with the decrease of NF-κB activity and the downregulation of some proinflammatory cytokines,including tumor necrosis factor-alpha(TNF-α)and interleukin(IL)-2.Our data suggested that the activities of NF-κB and Wnt/β-catenin/GSK3β pathways were both increased and inhibiting NF-κB and Wnt/β-catenin/GSK3β signaling pathways might improve myocardial injury in T1DM rats.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.300102278402)。
文摘The lithofacies classification is essential for oil and gas reservoir exploration and development.The traditional method of lithofacies classification is based on"core calibration logging"and the experience of geologists.This approach has strong subjectivity,low efficiency,and high uncertainty.This uncertainty may be one of the key factors affecting the results of 3 D modeling of tight sandstone reservoirs.In recent years,deep learning,which is a cutting-edge artificial intelligence technology,has attracted attention from various fields.However,the study of deep-learning techniques in the field of lithofacies classification has not been sufficient.Therefore,this paper proposes a novel hybrid deep-learning model based on the efficient data feature-extraction ability of convolutional neural networks(CNN)and the excellent ability to describe time-dependent features of long short-term memory networks(LSTM)to conduct lithological facies-classification experiments.The results of a series of experiments show that the hybrid CNN-LSTM model had an average accuracy of 87.3%and the best classification effect compared to the CNN,LSTM or the three commonly used machine learning models(Support vector machine,random forest,and gradient boosting decision tree).In addition,the borderline synthetic minority oversampling technique(BSMOTE)is introduced to address the class-imbalance issue of raw data.The results show that processed data balance can significantly improve the accuracy of lithofacies classification.Beside that,based on the fine lithofacies constraints,the sequential indicator simulation method is used to establish a three-dimensional lithofacies model,which completes the fine description of the spatial distribution of tight sandstone reservoirs in the study area.According to this comprehensive analysis,the proposed CNN-LSTM model,which eliminates class imbalance,can be effectively applied to lithofacies classification,and is expected to improve the reality of the geological model for the tight sandstone reservoirs.
文摘AIM: To clinically differentiate nanophthalmos(NO) and posterior microphthalmos(PM) and to explore the mechanisms related to papillomacular folds(PMF).METHODS: Medical records of 34 unrelated patients with microphthalmos(54 eyes) from April 2009 to October 2017 were retrospectively reviewed.RESULTS: Fourteen eyes of 7 unrelated patients with NO and PM were included in the study. The presenting age of the NO cohort was significantly higher compared with the PM cohort(NO: 27±16 y; PM: 3.7±0.6 y). PMF was more likely to occur in cases with PM than in NO(25% in NO, 100% in PM). The anatomic features of PMF from optical coherence tomography(OCT) included: ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and outer nuclear layer. In eyes without an apparent PMF(these were all NO eyes), rudimentary fovea without a foveal pit was noted. Four eyes that were NO developed angle closure glaucoma. Three NO eyes developed exudative retinal detachment and were successfully treated with lamellar sclerectomy.CONCLUSION: Posterior segment changes are pervasive both in PM and NO. Complications like angle closure glaucoma and exudative retinal detachment are likely to occur in eyes with NO but not with PM. Detailed OCT analysis found that PMF was partially a neural retinal issue, suggesting that redundancy of retinal issues involved only inner retinal layers.
基金The study was supported by the Innovation Program of Shanghai Municipal Education Commission(Grant No.12ZS080).
文摘Purpose:To assess the effectiveness of automated external defibrillator(AED)and manual external defibrillator(MED)training for third-year nurse students.Methods:We conducted post-demonstration and post-practice evaluation for MED defibrillation,and pre-training,post-demonstration,and post-practice evaluation for AED defibrillation.Results:Following MED training,time and confidence to defibrillate were improved significantly post-practice(p<0.001,p<0.001,respectively).In post-demonstration and postpractice evaluation,most students placed electrodes correctly(84.21%vs.80.70%),cleared before defibrillation(75.44%vs.89.47%),and performed cardiopulmonary resuscitation immediately after defibrillation(81.81%vs.94.44%);the evaluations were not statistically different(p=0.806,p=0.094,p=0.198,respectively).For AED training,time and confidence to defibrillate post-demonstration and post-practice were significantly improved(p<0.001 vs.p<0.001;p<0.001 vs.p<0.001,respectively)compared to that of pre-training;there was no obvious difference between the post-demonstration and postpractice evaluation(p=0.235,=0.346,respectively).Post-AED demonstration,most students could place electrodes correctly(85.96%),clear(91.23%),and perform CPR immediately after defibrillation(85.96%),which remained at a high level post-practice(94.74%,85.96%,82.46%,respectively);there was no significant difference between the two evaluations(p=0.203,p=0.557,p=0.776,respectively).Conclusion:Combining MED and AED defibrillation training is effective and feasible for third-year nurse students.Minimal training is effective for AED,while MED requires additional practice.
基金supported in part by the National Natural Science Foundation of China (Grant Nos. 11565020 and 10773005)the Counterpart Foundation of Sanya (Grant 2016PT43)+2 种基金the Special Foundation of Science and Technology Cooperation for Advanced Academy and Region of Sanya (Grant 2016YD28)the Scientific Research Starting Foundation for 515 Talented Project of Hainan Tropical Ocean University (Grant RHDRC201701)the Natural Science Foundation of Hainan Province (Grant No. 114012)
文摘Taking into account the effect of electron screening on electron energy and electron capture threshold energy, by using the method of Shell-Model Monte Carlo and random phase approximation theory, we investigate the capture rates of chromium isotopes with strong electron screening according to the linear response theory screening model. Strong screening rates can decrease by about 40.43% (e.g., for 6Cr at T9 = 3.44, Ye = 0.43). Our conclusions may be helpful to researches on supernova explosions and related numerical simulation methods.
基金supported by the China National Science Fund Committee (No. 30872393)Postgraduate Innovation Foundation of Simcere Pharmaceutical Group(No. CX10B-004XS)
文摘Cancer cell vaccine-based immunotherapy has received increasing interest in many clinical trials involving patients with breast cancer. Combining with appropriate adjuvants can enhance the weak immunogenic properties of tumor cell lysates (TCL). In this study, diphtheria toxin (DT) and two tandem repeats of mycobacterial heat shock protein 70 (mHSP70) fragment 407-426 (M2) were conjugated to TCL with glutaraldehyde, and the constructed cancer cell vaccine was named DT-TCL-M2. Subcutaneous injection of DT-TCL-M2in mice effectively elicited tumor-specific polyclonal immune responses, including humoral and cellular immune responses. High levels of antibodies against TCL were detected in the serum of immunized mice with ELISA and verified with Western blot analyses. The splenocytes from immunized mice showed potent cytotoxicity on Ehrlich ascites carcinoma cells. Moreover, the protective antitumor immunity induced by DT-TCL-M2 inhibited tumor growth in a mouse breast tumor model. DT-TCL-M2 also attenuated tumor-induced angiogenesis and slowed tumor growth in a mouse intradermal tumor model. These findings demonstrate that TCL conjugated with appropriate adjuvants induced effective antitumor immunity in vivo. Improvements in potency could further make cancer cell vaccines a useful and safe method for preventing cancer recurrence after resection.
基金supported by the National Scientifc Foundation of China(NSFC nos.9081710330973672 and 20775055)+2 种基金Doctoral Fund of Ministry of Education of China(No 20110141110024)Hubei Provincial Scientifc Foundation(No 2011CDB475)the Fundamental Research Funds for the Central Universities
文摘A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation and detection conditions of HPLC were optimized. Chiral bavachinin were separated with the mobile phase of methanol and water (70:30, v/v) at a flow rate of 1.0 mL/min. The linear ranges were in the range of 20-1000 μg/mL. The detection limits were tested as 4 ng/mL and 6 ng/mL for (+)-bavachinin and (-)-bavachinin, respectively. The method has been applied to analyze chiral bavachinin in rat plasma. HPLC-MS method was used to test the accuracy.
基金supported by the Clinical Support program of General Hospital of PLA(No.2018FC-WJFWZX-2-19)Military Medical Innovation Program(18CXZ009)。
文摘Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Therefore,this study aimed to explore the impact of the Standard Operation Procedure(SOP)and checklist on Chinese military medics’ability to manage snakebite first aid.Methods:This study was a prospective single-blind randomized controlled trial conducted in a military medical university of China from May to June 2017.A questionnaire-based survey was performed to collect the participants’socio-demographic profiles before the baseline measurement.During the baseline measurement,participants were requested to provide corresponding first aid that was responsive to the simulative situation portrayed by the standardized patients(SPs)and the evaluators then scored their performances according to a checklist for snakebite first aid scoring table.After the baseline measurement,they were randomly assigned to one of three intervention groups after stratification according to their baseline performance scores:group A received a self-learning course with textbooks(n=27),group B received a self-learning training on the SOP and checklist(n=27)and group C was engaged in an interactive discussion panel regarding the SOP and checklist(n=26).After the interventions,participants received outcome measurements about snakebite first aid key points capability from the same evaluator and SP for each group to avoid observational error.The reviewers were blinded about the grouping in the trial.Results:The baseline measurement yielded no significant difference(H=1.647,P=0.439)among the three groups.The post-intervention scores were higher than the pre-intervention scores for all three(A,B and C)groups(P=0.008,P<0.001 and P<0.001,respectively).There was significant difference of the post-intervention scores among the three groups(F=8.841,P<0.001).Both post-intervention scores of group B and group C were higher than that of group A(P<0.001 and P=0.001,respectively),but no difference was found between group B and C(P=0.695).The acceptance questionnaire score of SOP and checklist was mostly very satisfied,as the final scores of group B and group C were 4.62±0.61 and 4.82±0.45,respectively.Conclusions:In this study,the implementation of an SOP and checklist for snakebite first aid was shown to update and improve first aid treatment concepts in military medics.These intervention methods played an important role in improving the medics’cognition and understanding of snakebite first aid.Therefore,this finding suggests that SOP and checklist training should be further implemented in Chinese troops for snakebite care.
基金supported by the Natural Science Foundation of Hainan province (Grant No.114012)
文摘Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in presupemova surroundings. The results show that the EC rates are affected greatly at different densities and temperatures. The rates increase greatly and even exceed six orders of magnitude at lower temperature. On the other hand, the NES is very sensitive to stellar temperature and electron energy. The higher the temperature and the lower the electron energy, the larger the influence on NES is. For example, the maxima of NES in the ground state are 9.02, 160, 80, 24.01, 0.44, 1.42 me c^2 for ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V respectively at ρ7 = 10.7, Ye = 0.45 and T9 = 15. Furthermore, the influence on NES due to EC for different nuclei has some otherness because of different Qo-values. For example, the spectrum of ^56Co shows a double bump structure.
基金supported by the National Natural Science Foundation of China (Grant No. 11565020)the Counterpart Foundation of Sanya (Grant No. 2016PT43)+2 种基金the Special Foundation of Science and Technology Cooperation for Advanced Academy and Regional of Sanya (Grant No. 2016YD28)the Natural Science Foundation of Hainan province (Grant No. 114012)the Natural Science Foundation of Jiangxi Province (Grant No. 20132BAB212005)
文摘By introducing the Dirac δ-function and Pauli exclusion principle in the presence of superstrong magnetic fields (SMFs), we investigate the influence of SMFs on beta decay and the change rates of electron fraction (CREF) of nuclides 56Fe, 62Ni, 64Ni and 6SNi in magnetars, which are powered by magnetic field energy. We find that the magnetic fields have a great influence on the beta decay rates, and the beta decay rates can decrease by more than six orders of magnitude in the presence of SMFs. The CREF also decreases by more than seven orders of magnitude in the presence of SMFs.