Correction:Establishment of a prediction model for prehospital return of spontaneous circulation in out-of-hospital patients with cardiac arrest

This is an erratum to an already published paper named“Establishment of a prediction model for prehospital return of spontaneous circulation in out-ofhospital patients with cardiac arrest”.We found errors in the affiliated institution of the authors.We apologize for our unintentional mistake.Please note,these changes do not affect our results.

Establishment of a prediction model for prehospital return of spontaneous circulation in out-of-hospital patients with cardiac arrest

BACKGROUND Out-of-hospital cardiac arrest(OHCA)is a leading cause of death worldwide.AIM To explore factors influencing prehospital return of spontaneous circulation(P-ROSC)in patients with OHCA and develop a nomogram prediction model.METHODS Clinical data of patients with OHCA in Shenzhen,China,from January 2012 to December 2019 were retrospectively analyzed.Least absolute shrinkage and selection operator(LASSO)regression and multivariate logistic regression were applied to select the optimal factors predicting P-ROSC in patients with OHCA.A nomogram prediction model was established based on these influencing factors.Discrimination and calibration were assessed using receiver operating charac-teristic(ROC)and calibration curves.Decision curve analysis(DCA)was used to evaluate the model’s clinical utility.RESULTS Among the included 2685 patients with OHCA,the P-ROSC incidence was 5.8%.LASSO and multivariate logistic regression analyses showed that age,bystander cardiopulmonary resuscitation(CPR),initial rhythm,CPR duration,ventilation mode,and pathogenesis were independent factors influencing P-ROSC in these patients.The area under the ROC was 0.963.The calibration plot demonstrated that the predicted P-ROSC model was concordant with the actual P-ROSC.The good clinical usability of the prediction model was confirmed using DCA.CONCLUSION The nomogram prediction model could effectively predict the probability of P-ROSC in patients with OHCA.

Interpeduncular cistern intrathecal targeted drug delivery for intractable postherpetic neuralgia: A case report

BACKGROUND Intractable postherpetic neuralgia(PHN)can be difficult to manage even with aggressive multimodal therapies.Patients who experience uncontrolled refractory cranial PHN despite conservative treatment may benefit from an intrathecal drug delivery system(IDDS).For craniofacial neuropathic pain,the traditional approach has been to place the intrathecal catheter tip below the level of the cranial nerve root entry zones,which may lead to insufficient analgesia.CASE SUMMARY We describe a 69-year-old man with a 1-year history of PHN after developing a vesicular rash in the ophthalmic division of cranial nerve V(trigeminal nerve)distribution.The pain was rated 7-8 at rest and 9-10 at breakthrough pain(BTP)on a numeric rating scale.Despite receiving aggressive multimodal therapies including large doses of oral analgesics(gabapentin 150 mg q12 h,oxycodone 5 mg/acetaminophen 325 mg q6 h,and lidocaine 5%patch 700 mg q12 h)and sphenopalatine ganglion block,there was no relief of pain.Subsequently,the patient elected to have an implantable IDDS with the catheter tip placed at the interpeduncular cistern.The frequency of BTP episodes decreased.The patient’s continuous daily dose was adjusted to 0.032 mg/d after 3 mo of follow-up and stopped 5 mo later.He did not report pain or other discomfort at outpatient follow-up 6 mo and 1 year after stopping intracisternal hydromorphone.CONCLUSION The use of interpeduncular cistern intrathecal infusion with low-dose hydromorphone by IDDS may be effective for severe craniofacial PHN.

Simultaneous detection of CH_(4)and CO_(2)through dual modulation off-axis integrated cavity output spectroscopy

This study established a novel method for the simultaneous detection of two-component gases.Radio frequency(RF)white noise disturbance laser current and wavelength modulation were simultaneously used to improve the off-axis integrated cavity output spectroscopy technique,and a high-precision dual modulation OA-ICOS(RF-WM-OA-ICOS)system was established.The two laser beams were coupled into one laser beam that was applied incident to the cavity of RF-WM-OA-ICOS system.The second harmonic signals of CH_(4)and CO_(2)gas simultaneously appeared in the rising or falling edge of a triangular wave.This method was used to measure CH_(4)and CO_(2)with different concentrations.The results indicated that the proposed system has high stability and can accurately and simultaneously measure the concentrations of CH_(4)and CO_(2),with an optimal integration time of 220 s.The minimum detection limit was 10 ppb for CH_(4)and 1.5 ppm for CO_(2).The corresponding noise equivalent absorption sensitivity values were calculated as 2.67×10^(-13)cm^(-1)·Hz^(-1/2)and 5.18×10^(-11)cm^(-1)·Hz^(-1/2),respectively.The proposed dual-component gas simultaneous detection method can also be used for high-precision simultaneous detection of other gases.Therefore,this study may serve as a reference for developing portable multicomponent gas analyzers.

New Photometric Investigations of G-type Contact Binary TU Boo

Two sets of CCD photometric observations for contact binary TU Boo were obtained in 2020 and 2021.Different from its asymmetric light curves published from the literature,our BVRcIc-band curves show that the heights of maximum are almost equal.These distortions of light curves possibly indicate that the components were active in past 25 yr,but they were stable in the last two years.For total-eclipse binary TU Boo,due to some star-spots on the surface of the components,the physical structure obtained by many investigators are different.Therefore,the symmetric multi-color light curves in 2020,2021 are important for understanding configuration and evolution of this system.By using the Wilson–Devinney program,it is confirmed that TU Boo is an A-type shallow-contact binary with the temperature difference ofΔT=152 K and fill-out of f=14.67%.In the O−C diagram of orbital period analysis,a cyclic oscillation superimposed on a continuous decrease was determined.The long-term decreasing is often explained by the mass transfer from the more massive star to less massive one,this system will evolve into a deeper contact binary with time.The cyclic oscillations computed from much more CCD times of light minimum maybe result from the light-travel time effect via the presence of a third body.These characters of structure,evolution and ternary belong to typical A-type W UMa binaries with spectral G.

Development and application of multi-field coupled high-pressure triaxial apparatus for soil

The increasing severity of ground subsidence,ground fissure and other disasters caused by the excessive exploitation of deep underground resources has highlighted the pressing need for effective management.A significant contributing factor to the challenges faced is the inadequacy of existing soil mechanics experimental instruments in providing effective indicators,creating a bottleneck in comprehensively understanding the mechanisms of land subsidence.It is urgent to develop a multi-field and multi-functional soil mechanics experimental system to address this issue.Based soil mechanics theories,the existing manufacturing capabilities of triaxial apparatus and the practical demands of the test system,a set of multi-field coupled high-pressure triaxial system is developed tailored for testing deep soils(at depths of approximately 3000 m)and soft rock.This system incorporates specialized design elements such as high-pressure chamber and horizontal deformation testing devices.In addition to the conventional triaxial tester functions,its distinctive feature encompass a horizontal deformation tracking measuring device,a water release testing device and temperature control device for the sample.This ensemble facilitates testing of horizontal and vertical deformation water release and other parameters of samples under a specified stress conditions,at constant or varying temperature ranging from-40℃–90℃.The accuracy of the tested parameters meets the requirements of relevant current specifications.The test system not only provides scientifically robust data for revealing the deformation and failure mechanism of soil subjected to extreme temperature,but also offers critical data support for major engineering projects,deep exploration and mitigation efforts related to soil deformation-induced disaster.

Chinese nursing postgraduates'views on implementing outcome-oriented academic English course:a descriptive study

Background:According to previous studies on professional English course teaching,the evaluation of course teaching was positive,but the vast majorities focus on medical English literature reading,professional English vocabulary,and professional English translation.As an alternative,the course design based on academic learning needs under the outcome-oriented education/model emphasizes the improvement of students'comprehensive ability in oral expression,literature reading,writing,and academic communication.Objectives:The objective of this study was to analyze nursing postgraduates'opinions on learning the outcome-oriented academic English course.Methods:This is a cross-sectional descriptive study.A total of 150 first-year nursing postgraduates enrolled in the“Academic Professional English for Nursing Postgraduates”course.After completing the course learning,students scanned QR codes generated by the online questionnaire and completed it anonymously within 48 h.Results:The students who participated in this course strongly believed that it“helped them strengthen their English speakability”(4.8 points),“made them more confident to participate in international academic conferences and exchanges in the future”(4.8 points),and“helped them apply English more in the nursing professional field in the future”(4.7 points).Conclusions:The implementation of outcome-oriented course teaching helps students to understand the research of foreign scholars and effectively express their own research content with English as a tool.It motivates them to continuously use English for professional and academic communication.

超声内镜在食管结核诊断中的9例应用并文献复习

目的总结食管结核超声内镜(EUS)声像图特征及其他临床资料结果,提高该病的诊断率。方法回顾性分析该院2011年6月-2016年5月经EUS检查或内镜超声引导下细针穿刺活检(EUS-FNA)而确诊为食管结核的9例患者的临床资料,并复习国内外文献。结果 9例患者中,表现为吞咽梗阻6例,胸骨后疼痛3例,伴有盗汗、低热症状2例,伴咳嗽、咯血1例,伴咽痛1例;病变位于食管中段7例(77.78%),上段1例,食管下段合并咽部病变1例;8例为隆起型病变,其中4例表面破溃,1例呈息肉样隆起,另1例为溃疡并憩室型病变;内镜下活检6例中5例确诊,其中3例活检2次;EUS表现为食管壁内不均质低回声占位,边界模糊,内见高回声光斑,侵及黏膜下层或全层,部分病灶突破外膜层与壁外肿大淋巴结融合贯通;2例行EUS-FNA穿刺,病理发现炎性肉芽肿,考虑结核;均予以抗结核治疗后症状缓解。结论食管结核临床表现主要为吞咽困难,好发于食管中段,内镜下表现主要为隆起型和溃疡型病变,通过多次内镜下活检,结合EUS特征或EUS-FNA穿刺病理学检查能明显提高该病的诊断率,减少误诊率。

关于糖尿病视网膜病变患者脉络膜血管指数的初步研究

目的:探讨并发糖尿病视网膜病变(DR)的2型糖尿病患者与健康人群脉络膜血管指数(CVI)的差异及特点。方法:选取2017-01/12于我院就诊的并发DR的2型糖尿病患者68例68眼作为DR组,同时纳入同期体检的无糖尿病病史健康人群34例34眼作为对照组。通过频域相干光层析深度增强成像术(EDI-OCT)获取受检者黄斑中心凹下脉络膜厚度(SFCT)、黄斑中心凹处视网膜厚度(CRT),并将黄斑区图像进行二值化处理,采用图像分析软件计算黄斑区脉络膜总面积(TCA)、血管区面积(LA)及间质区面积(SA),计算CVI。结果:对照组和DR组受检者TCA(0.53±0.14mm2 vs 0.49±0.15mm2)、LA(0.35±0.09mm2 vs 0.32±0.10mm2)、SA(0.17±0.05mm2 vs 0.17±0.06mm2)及SFCT(347.9±76.9μm vs 325.9±92.9μm)均无差异(P>0.05),但DR组患者CVI明显低于对照组(64.33%±3.25%vs 67.04%±2.46%,P<0.001),二者临界值为63.59%。结论:CVI可以直观反映脉络膜内部结构的变化,较SFCT更加稳定可靠,合并DR的2型糖尿病患者其CVI较健康人群降低。

强化克罗恩病监测和优化患者管理

近年来,克罗恩病(Crohn’s disease,CD)的治疗目标从临床缓解转向黏膜愈合.在这种情况下,CD的管理和监测格外重要.根据临床症状和炎症标志物及时调整治疗方案,有助于对患者进行监测,取得更好的临床和内镜治疗效果.然而目前还没有足够的证据来推荐仅考虑炎症标志物的治疗优化方案.治疗性药物监测(therapeutic drug monitoring,TDM)已被用于改善硫嘌呤和抗肿瘤坏死因子药物的治疗,被动性TDM适用于所有药物,为提高临床实用性,抗肿瘤坏死因子药物的监测应从被动性转变为主动性.主动的TDM对于优化非抗肿瘤坏死因子生物制剂的效用仍有待描述.此外,炎症标志物可以预测术后CD的复发,术后6-12 mo以及之后定期行结肠镜复查亦为重要.高危CD患者应考虑尽早在术后进行抗肿瘤坏死因子治疗,但抗肿瘤坏死因子预防性给药的最佳时间尚无统一意见,非抗肿瘤坏死因子生物制剂在术后预防性给药中的作用还需研究.本文主要综述了炎症标志物的监测、药物监测及术后患者的监测,进而优化CD患者管理,使更多的患者达到治疗目标,指出了CD患者密切监测的重要性.

Clopidogrel resistance response in patients with coronary artery disease and metabolic syndrome： the role of hyperglycemia and obesity

clopidogrel 的证明好处联合了的 BackgroundDespite 为冠的动脉疾病(CAD ) 的阿司匹林治疗，有新陈代谢的症候群(MS ) 的 CAD 病人仍然趋于有冠的 thrombotic 事件。我们试图与经历经皮的冠的干预(一种总线标准) 的 CAD 在病人在 clopidogrel 治疗的功效上调查新陈代谢的风险因素的影响有冠的 angiography (CAG ) 识别的 CAD 的 168 MS 和 168 个非 MS 题目的 .MethodsCohorts 在我们的学习被注册。MS 被修改成年治疗面板 III 标准定义。所有题目服 100 mg 阿司匹林和 75 mg clopidogrel 日报超过 1 个月了，并且管理装载 600 mg clopidogrel 和 300 mg 的剂量在一种总线标准前的阿司匹林。血样品在 clopidogrel 和阿司匹林的装载剂量以后被花 24 h。血小板聚集用轻发射度 aggregometry (LTA ) 和 thrombelastography (两岁的羊) 被测量。Clopidogrel 抵抗是定义 as&#x000a0；超过 50% 腺苷 diphosphate (自动数据处理) 导致了由自动数据处理由 TEG.ResultsPlatelet 聚集抑制率测量了的血小板聚集在有由两岁的羊测量了两个的 MS 的病人是显著地更低的(55%&#x000b1；31% 对 68%&#x000b1；32% ；P &#x0003c；0.001 ) 并且 LTA (29%&#x000b1；23% 对 42%&#x000b1；29% ；P &#x0003c；0.001 ) 。在 multivariate 分析，老[或(95% CI ) ：1.483 (1.047-6.248 ) ；P = 0.002 ] ，肥胖[或(95% CI ) ：3.608 (1.241-10.488 ) ；P = 0.018 ] ，高 fasting 血浆葡萄糖水平[或(95% CI ) ：2.717 (1.176-6.277 ) ；P = 0.019 ] 并且 hyperuricemia [或(95% CI ) ：2.583 (1.095-6.094 ) ；P = 0.030 ] 都统计上为 clopidogrel 抵抗冒险因素。有糖尿病和肥胖的 CAD 病人是更可能的没有糖尿病和肥胖，比 CAD 病人有 clopidogrel 抵抗[75%(61/81 ) 对 43%(67/156 ) ；P &#x0003c；0.001 ] 没有 MS，有 MS 的 .ConclusionsCAD 病人看起来与那些相比有更差的 antiplatelet 反应到 clopidogrel。肥胖，糖尿病和 hyperuricemia 都显著地与 clopidogrel 抵抗被联系。

Experimental infection of tree shrews(Tupaia belangeri) with Coxsackie virus A16

Coxsackie virus A16(CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease(HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews(Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.

他克莫司治疗炎症性肠病的最新进展

炎症性肠病(inflammatory bowel disease, IBD)的传统用药包括氨基水杨酸制剂、糖皮质激素、免疫抑制剂如硫嘌呤类、环孢素等药物.近十多年来,抗肿瘤坏死因子药物(anti-tumor necrosis factor, anti-TNF)的应用使IBD患者的临床缓解方面取得了显著进展,但其仍然存在无反应、无法耐受和停用后复发等问题.近些年来发现,他克莫司,一种新型强效免疫抑制剂,作为治疗IBD的二线治疗药物被使用.目前,他克莫司的短期诱导缓解作用相对明显,被逐渐应用在传统药物难治或者anti-TNF难治的IBD中.少数研究发现,在适当的监测下,他克莫司可以长期安全地使用.但其长期疗效和长期使用安全性的证据还比较少.本文就他克莫司在IBD中的治疗最新进展及其与anti-TNF的比较作一综述.

An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes

An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 （CYP） enzymes. This method employed a cocktail of six probe substrates （i.e., phenacetin, amodiaquine, diclofenac, S-mephenytoin, dextromethorphan and midazolam for CYPIA2, 2C8, 2C9, 2C19, 2D6 and 3A4, respectively） as well as individual prototypical inhibitors of the six CYP enzymes in human liver microsomes under optimized incubation conditions. The corresponding marker metabolites （i.e., acetaminophen, N-desethylamodiaquine, 4-OH-diclofenac, 4-OH-S- mephenytoin, dextrorphan and 1-OH-midazolam） in the incubates were quantified using LC-MS/MS methods either by an internal standard （IS） calibration curve or a simpfified analyte-to-IS peak area ratio approach. The results showed that the IC5o values determined by the cocktail approach were in good agreement with those obtained by the individual substrate approach as well as those reported in the literature. Besides, no remarkable difference was observed between the two quantification approaches. In conclusion, this new cocktail assay can be used for reliable screening of compound-mediated CYP inhibition.

Isolation and Complete Genomic Sequence Analysis of a New Sindbis-like Virus

象 Sindbis 一样病毒首先在 1986 在中国被发现。它的完全的染色体组的顺序由编码超过 3 的超过 11 000 bp 组成 700 氨基酸。它在一个非结构的区域包含 5 鈥?n on-transcriptional 区域(5 鈥?N TR ) ，四非结构的蛋白质(nsP1， nsP2， nsP3， nsP4 ) 区域，衣壳在保存；非保存的区域；结构的 E1， E2， E3， 6K 区域；3 鈥?n on-transcriptional 区域(3 鈥?N TR ) 。Sindbis-IMB 从怀疑有脑炎的一个病人的血被孤立，；被鉴定跟随；经过。病毒核糖核酸在感染的房间从病毒上层清液被提取；整个染色体被划分成 12 碎片；RT-PCR 然后被执行为完全的定序放大 12 碎片。结果证明 Sindbis-IMB 的整个染色体组的顺序由编码 3 的 11 717 bp 组成 773 氨基酸。象 Sindbis 一样孤立的与其它一起的相同比较证明最高的类似是有在云南省孤立的 1% 紧张的一个变化的 YN87448；第二最高与锝? 的一个变化拉紧到 SAAR86 2% 。核苷酸序列变化在非结构的区域是在场的，导致氨基酸 K， E， N， R， H，；在在位置的蛋白质序列的 L 230， 231， 443,781， 1 582，；1746 在新隔离分别地。而且，三另外的氨基酸—glutamic，丝氨酸；丙氨酸—作为与 YN87448 isolate 相比在 nsp4 终点被注意。

Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms

AIM： To investigate the effect of interleukin-8（IL-8） on neural retinal ganglion cells（RGCs） and whether it can be alleviated by G31P. METHODS： RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the cell viability was assessed by Cell Counting Kit 8（CCK-8）. Apoptosis was measured by examining nuclear morphology and quantifying with flow cytometry. Reverse transcription quantitative real-time polymerase chain reaction（RT-qP CR） and Western blot were used to investigate the expression of apoptosis-related genes. RESULTS： CCK-8 assay showed that IL-8 significantly inhibits the viability of RGC-5 cells in a dose-dependent manner. Cell apoptosis assays exhibited higher apoptotic rate in IL-8 treatment group compared to control group. We further found that IL-8 could promote Bax and caspase-3 expressions, but decrease the level of Bcl-2 in the aspect of m RNA and protein. However, pre-treatment with G31P partly attenuated these effects in RGC-5 cells（P〈0.05）.CONCLUSION： These results indicate that anti-proliferation effects of IL-8 through induction of cell apoptosis regulated by Bcl-2, Bax and caspase-3 expressions, can be ameliorated by G31P.

Dysbiosis of gut microbiome affecting small intestine morphology and immune balance:a rhesus macaque model

There is a growing appreciation for the specific health benefits conferred by commensal microbiota on their hosts.Clinical microbiota analysis and animal studies in germ-free or antibiotic-treated mice have been crucial for improving our understanding of the role of the microbiome on the host mucosal surface;however,studies on the mechanisms involved in microbiome-host interactions remain limited to small animal models.Here,we demonstrated that rhesus monkeys under short-term broad-spectrum antibiotic treatment could be used as a model to study the gut mucosal host-microbiome niche and immune balance with steady health status.Results showed that the diversity and community structure of the gut commensal bacteria in rhesus monkeys were both disrupted after antibiotic treatment.Furthermore,the 16S rDNA amplicon sequencing results indicated that Escherichia-Shigella were predominant in stool samples 9 d of treatment,and the abundances of bacterial functional genes and predicted KEGG pathways were significantly changed.In addition to inducing aberrant morphology of small intestinal villi,the depletion of gut commensal bacteria led to increased proportions of CD3+T,CD4+T,and CD16+NK cells in peripheral blood mononuclear cells(PBMCs),but decreased numbers of Treg and CD20+B cells.The transcriptome of PBMCs from antibiotic-treated monkeys showed that the immune balance was affected by modulation of the expression of many functional genes,including IL-13,VCAM1,and LGR4.

Hyperactive reactive oxygen species impair function of porcine Sertoli cells via suppression of surface protein ITGB1 and connexin-43

DEAR EDITOR,Gap junctions regulate intercellular communication between Sertoli cells and germ cells in male testes and play vital functions in spermatogenesis.Many factors in animal breeding and husbandry can induce oxidative stress,which can impair the testis microenvironment and male animal fertility.However,the underlying mechanisms are largely unknown.Recently,we identified that androgen signals promote the expression of connexin-43(Cx43),a key component of gap junctions,to regulate spermatogenesis.Thus,we asked whether hyperactive reactive oxygen species(ROS)can impair gap junctions by interfering with Cx43 in porcine testes.Using a porcine Sertoli cell in vitro system,we found that hyperactive ROS caused extensive apoptosis in Sertoli cells,remarkable decrease in Cx43 expression,and failed maintenance of co-cultured spermatogonial stem cells(SSCs),indicating that ROS impaired the function of Sertoli cells and promoted loss of SSCs.This observation provides a possible mechanism for the impact of ROS on fertility of male animals.

Ohmic contact properties of p-type surface conductive layer on H-terminated diamond films prepared by DC arc jet CVD

With the advantages of high deposition rate and large deposition area, polycrystalline diamond films prepared by direct current （DC） arc jet chemical vapor deposition （CVD） are considered to be one of the most promising materials for high-frequency and high-power electronic devices. In this paper, high-quality self-standing polycrystalline diamond films with the diameter of 100 mm were prepared by DC arc jet CVD, and then, the p-type surface conductive layer with the sheet carrier density of 10^11-10^13 cm-2 on the H-terminated diamond film was obtained by micro-wave hydrogen plasma treatment for 40 min. Ti/Au and Au films were deposited on the H-terminated diamond surface as the ohmic contact electrode, respectively, afterwards, they were treated by rapid vacuum annealing at different temperatures. The properties of these two types of ohmic contacts were investigated by measuring the specific contact resistance using the transmission line method （TLM）. Due to the formation of Ti-related carbide at high temperature, the specific contact resistance of Ti/Au contact gradually decreases to 9.95 × 10^-5 Ω-cm2 as the temperature increases to 820℃. However, when the annealing temperature reaches 850℃, the ohmic contact for Ti/Au is degraded significantly due to the strong diffusion and reaction between Ti and Au. As for the as-deposited Au contact, it shows an ohmic contact. After annealing treatment at 550℃, low specific contact resistance was detected for Au contact, which is derived from the enhancement of interdiffusion between Au and diamond films.

Predictive value of blood concentration of biologics on endoscopic inactivity in inflammatory bowel disease:A systematic review

BACKGROUND Although blood concentration of biologics is an important composition of disease management in inflammatory bowel disease(IBD)patients,complexity and uncertainty of biological management encourage many disputes in predicting the outcome of IBD patients through blood concentration of biologics.AIM To verify the predictive value of blood concentration of biologics on endoscopic inactivity in IBD patients under different situations.METHODS We searched PubMed/MEDLINE,Embase,and Web of Science up to May 2020 and identified IBD patients as the research cohort as well as the correlations between blood concentration of biologics and endoscopic inactivity in IBD patients as the research direction.RESULTS A total of 23 articles with 30 clinical studies and 1939 IBD patients were included.The predictive cut-off value of blood concentration of infliximab on mucosal healing should be 2.7-10.6μg/mL in IBD.Blood concentration of infliximab reaching 5.0-12.7μg/mL or more increased the probability of fistula healing/closure in perianal fistulizing Crohn's disease.Blood concentration of adalimumab reaching 7.2-16.2μg/mL or more could predict mucosal healing in IBD.The predictive cut-off value of blood concentration of adalimumab on fistula healing/closure should be 5.9-9.8μg/mL in perianal fistulizing Crohn's disease.Blood concentration of vedolizumab surpassing 25.0μg/mL indicated mucosal healing in ulcerative colitis patients under maintenance therapy and the predictive cut-off value of blood concentration on mucosal healing or endoscopic remission under induction therapy in IBD could be 8.0-28.9μg/mL.CONCLUSION Blood concentration of biologics should not be utilized to predict endoscopic inactivity of IBD independently due to discrepancies in clinical studies,whereas conducting therapeutic drug monitoring intensively contributes to precise therapy.