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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer
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作者 Hai-Luo wang Ruo-Ran Zhang +7 位作者 Hao wang Peng Xu jing-kai wang Bo Chen Hao Xu Deng Pan Yu-Yang Ma Kun Pang 《Traditional Medicine Research》 2025年第1期62-72,共11页
Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and al... Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients. 展开更多
关键词 traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy
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An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration 被引量:1
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作者 Kai-shun Xia Dong-dong Li +13 位作者 Cheng-gui wang Li-wei Ying jing-kai wang Biao Yang Jia-wei Shu Xian-peng Huang Yu-ang Zhang Chao Yu Xiao-peng Zhou Fang-cai Li Nigel K.H.Slater Jian-bin Tang Qi-xin Chen Cheng-zhen Liang 《Bioactive Materials》 SCIE CSCD 2023年第3期69-85,共17页
Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration(IDD).Current limitations of stem cells include with their insufficient cell source,poor proliferation capacity,l... Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration(IDD).Current limitations of stem cells include with their insufficient cell source,poor proliferation capacity,low nucleus pulposus(NP)-specific differentiation potential,and inability to avoid pyroptosis caused by the acidic IDD microenvironment after transplantation.To address these challenges,embryo-derived long-term expandable nucleus pulposus progenitor cells(NPPCs)and esterase-responsive ibuprofen nano-micelles(PEG-PIB)were prepared for synergistic transplantation.In this study,we propose a biomaterial pre-modification cell strategy;the PEG-PIB were endocytosed to pre-modify the NPPCs with adaptability in harsh IDD microenvironment through inhibiting pyroptosis.The results indicated that the PEG-PIB pre-modified NPPCs exhibited inhibition of pyroptosis in vitro;their further synergistic transplantation yielded effective functional recovery,histological regeneration,and inhibition of pyroptosis during IDD regeneration.Herein,we offer a novel biomaterial pre-modification cell strategy for synergistic transplantation with promising therapeutic effects in IDD regeneration. 展开更多
关键词 Intervertebral disc degeneration Nucleus pulposus progenitor cells Esterase-responsive nano micell Biomaterial pre-modification Synergistic transplantation therapy
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