AIM To explore the expression profiles of microRNAs(miRNAs), long non-coding RNAs(lncRNAs), and mRNAs in oesophageal squamous cell carcinoma(ESCC) in order to construct an oesophageal cancer-specific competing endogen...AIM To explore the expression profiles of microRNAs(miRNAs), long non-coding RNAs(lncRNAs), and mRNAs in oesophageal squamous cell carcinoma(ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA(ceRNA) network.METHODS In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.RESULTS CeRNAs have the ability to reduce the targeting activityof miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development.CONCLUSION This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers.展开更多
基金Supported by the National Natural Science Foundation of China,No.31670895 and No.71673254
文摘AIM To explore the expression profiles of microRNAs(miRNAs), long non-coding RNAs(lncRNAs), and mRNAs in oesophageal squamous cell carcinoma(ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA(ceRNA) network.METHODS In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.RESULTS CeRNAs have the ability to reduce the targeting activityof miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development.CONCLUSION This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers.
