BACKGROUND Ligamentoid fibromatosis is a rare borderline tumor that occurs in the muscles,fascia,and aponeurosis.It is a kind of soft tissue tumor of fibrous origin,also known as invasive fibromatosis,desmoid fibroma,...BACKGROUND Ligamentoid fibromatosis is a rare borderline tumor that occurs in the muscles,fascia,and aponeurosis.It is a kind of soft tissue tumor of fibrous origin,also known as invasive fibromatosis,desmoid fibroma,neurofibromatosis,etc.The tumor is between benign and malignant tumors and rarely has distant metastasis.Its characteristics are mainly local invasion,destruction and growth and easy recurrence.The World Health Organization defines it as a fibroblast cloning value-added lesion originating from deep soft tissue,which causes local invasion and growth leading to tissue reconstruction,extrusion and destruction of important structures and organs.The incidence rate accounts for 0.03%of all tumors and less than 3%of all soft tissue tumors.Definite diagnosis mainly depends on postoperative pathology.Surgical resection is still the main way to treat the disease,and a variety of nonsurgical treatment methods are auxiliary.Combined treatment can effectively reduce the risk of postoperative recurrence.CASE SUMMARY The patient is a 57-year-old female.One week ago,she accidentally found a mass in the left upper abdomen while lying flat.There was no abdominal pain and abdominal distention,no fever,no black stool and blood in the stool and no nausea and vomiting.She had a 10-year history of glaucoma on the left side,underwent hysterectomy for uterine fibroids 5 years ago,had no hypertension,heart disease,diabetes,hepatitis or tuberculosis,had no history of smoking and had been drinking for 20 years.CONCLUSION Accurate preoperative diagnosis is difficult,surgical resection is the main treatment,and a variety of nonsurgical treatment methods are auxiliary.Combined treatment can effectively reduce the risk of postoperative recurrence.The prognosis is still good,and the risk of recurrence of secondary surgery is greatly increased.展开更多
AIM： To identify the distribution of N-acetyltrasferase 2 （NAT2） polymorphism in Hebei Han Chinese and the effects of the polymorphism on the development of colorectal cancer.METHODS： We performed a hospital-based...AIM： To identify the distribution of N-acetyltrasferase 2 （NAT2） polymorphism in Hebei Han Chinese and the effects of the polymorphism on the development of colorectal cancer.METHODS： We performed a hospital-based case-control study of 237 healthy individuals and 83 colorectal cancer patients of Hebei Han Chinese. DNA was extracted from peripheral blood and cancer tissues. The genotypes of the polymorphisms were assessed by PCR-restriction fragment length polymorphism（RFLP）.RESULTS： There were four NAT2 alleles of WT, M1, M2,and M3 both in the healthy subjects and in the patients,and 10 genotypes of WT/WT, WT/M1, WT/M2, WT/M3,M1/M1, M1/M2, M1/M3, M2/M2, M2/M3, M3/M3. M2 allele was present in 15.61% of healthy subjects and 29.52% of patients （X^2 = 15.31, P〈0.0001）, and M3 allele was present in 30.59% of healthy subjects and 16.87% of patients （X^2 = 25.33, P〈0.0001）. There were more WT/M2 （X^2= 34.42, P〈0.0001, odd ratio= 4.99, 95%CI = 2.27-9.38）and less WT/M3 （X^2 = 3.80, P = 0.03） in the patients than in the healthy subjects. In 70.3% of the patients, there was a difference in NAT2 genotype between their tumors and blood cells. Patients had more WT/M2 （7.2 = 5.11,P = 0.02） and less M2/M3 （X^2= 4.27, P = 0.039） in their blood cells than in the tumors. Furthermore, 53.8% （7/13）of M2/M3 in tumors were from VVT/M2 of blood cells.CONCLUSION： There is a possible relationship between the NAT2 polymorphisms and colorectal cancer in Hebei Han Chinese. The genotype WT/M2 may be a risk factor for colorectal cancer.展开更多
文摘BACKGROUND Ligamentoid fibromatosis is a rare borderline tumor that occurs in the muscles,fascia,and aponeurosis.It is a kind of soft tissue tumor of fibrous origin,also known as invasive fibromatosis,desmoid fibroma,neurofibromatosis,etc.The tumor is between benign and malignant tumors and rarely has distant metastasis.Its characteristics are mainly local invasion,destruction and growth and easy recurrence.The World Health Organization defines it as a fibroblast cloning value-added lesion originating from deep soft tissue,which causes local invasion and growth leading to tissue reconstruction,extrusion and destruction of important structures and organs.The incidence rate accounts for 0.03%of all tumors and less than 3%of all soft tissue tumors.Definite diagnosis mainly depends on postoperative pathology.Surgical resection is still the main way to treat the disease,and a variety of nonsurgical treatment methods are auxiliary.Combined treatment can effectively reduce the risk of postoperative recurrence.CASE SUMMARY The patient is a 57-year-old female.One week ago,she accidentally found a mass in the left upper abdomen while lying flat.There was no abdominal pain and abdominal distention,no fever,no black stool and blood in the stool and no nausea and vomiting.She had a 10-year history of glaucoma on the left side,underwent hysterectomy for uterine fibroids 5 years ago,had no hypertension,heart disease,diabetes,hepatitis or tuberculosis,had no history of smoking and had been drinking for 20 years.CONCLUSION Accurate preoperative diagnosis is difficult,surgical resection is the main treatment,and a variety of nonsurgical treatment methods are auxiliary.Combined treatment can effectively reduce the risk of postoperative recurrence.The prognosis is still good,and the risk of recurrence of secondary surgery is greatly increased.
文摘AIM： To identify the distribution of N-acetyltrasferase 2 （NAT2） polymorphism in Hebei Han Chinese and the effects of the polymorphism on the development of colorectal cancer.METHODS： We performed a hospital-based case-control study of 237 healthy individuals and 83 colorectal cancer patients of Hebei Han Chinese. DNA was extracted from peripheral blood and cancer tissues. The genotypes of the polymorphisms were assessed by PCR-restriction fragment length polymorphism（RFLP）.RESULTS： There were four NAT2 alleles of WT, M1, M2,and M3 both in the healthy subjects and in the patients,and 10 genotypes of WT/WT, WT/M1, WT/M2, WT/M3,M1/M1, M1/M2, M1/M3, M2/M2, M2/M3, M3/M3. M2 allele was present in 15.61% of healthy subjects and 29.52% of patients （X^2 = 15.31, P〈0.0001）, and M3 allele was present in 30.59% of healthy subjects and 16.87% of patients （X^2 = 25.33, P〈0.0001）. There were more WT/M2 （X^2= 34.42, P〈0.0001, odd ratio= 4.99, 95%CI = 2.27-9.38）and less WT/M3 （X^2 = 3.80, P = 0.03） in the patients than in the healthy subjects. In 70.3% of the patients, there was a difference in NAT2 genotype between their tumors and blood cells. Patients had more WT/M2 （7.2 = 5.11,P = 0.02） and less M2/M3 （X^2= 4.27, P = 0.039） in their blood cells than in the tumors. Furthermore, 53.8% （7/13）of M2/M3 in tumors were from VVT/M2 of blood cells.CONCLUSION： There is a possible relationship between the NAT2 polymorphisms and colorectal cancer in Hebei Han Chinese. The genotype WT/M2 may be a risk factor for colorectal cancer.
