Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence.However,due to the poor efficacy of the monotherapy in tumor immunotherapy,combination ...Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence.However,due to the poor efficacy of the monotherapy in tumor immunotherapy,combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy,photodynamic therapy/immunotherapy,sonodynamic therapy/immunotherapy and so on.Nanoscale metal-organic frameworks(nMOFs)are widely used for drug delivery because of their rich and variable composition,high drug loading capacity and good biodegradability.Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies.This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers,supplementary agents and drug carriers,respectively,with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.展开更多
The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn...The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome.Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21861009)the Thousands of Young and Middle-aged Backbone Teachers Training Project of Guangxi Colleges and Universities(No.Gui-Jiao 2020-58)+2 种基金Guangxi University of Traditional Chinese Medicine"Qihuang Project"High-level Talent Team Cultivation Programme(202408)the Gui Style Xinglin Top Talent Funding Project of Guangxi University of Chinese Medicine(Nos.2022C014 and 2022C005)the Innovation Project of Guangxi Graduate Education(Nos.YCSW2022342 and YCSW2023401)。
文摘Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence.However,due to the poor efficacy of the monotherapy in tumor immunotherapy,combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy,photodynamic therapy/immunotherapy,sonodynamic therapy/immunotherapy and so on.Nanoscale metal-organic frameworks(nMOFs)are widely used for drug delivery because of their rich and variable composition,high drug loading capacity and good biodegradability.Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies.This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers,supplementary agents and drug carriers,respectively,with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.
基金financially supported by the National Natural Science Foundation of China(Nos.22161009 and 82060641)the Thousands of Young and Middle-aged Backbone Teachers Training Project of Guangxi Colleges and Universities(No.Gui-Jiao 2020-58)+2 种基金Guangxi University of Chinese Medicine"Qihuang Project"High-level Talent Team Cultivation Programme(No.202408)Gui Style Xinglin Top Talent Funding Project of Guangxi University of Chinese Medicine(Nos.2022C014 and 2022C005)the Innovation Project of Guangxi Graduate Education(No.YCSW2022342)。
文摘The rational design of a specific co-drug delivery platform that can address the unavoidable resistance,toxic side effects and low targeting efficiency of traditional cancer treatments is of great meaningful.Herein,Zn-based MOF-zeolitic imidazole framework-90(ZIF-90)was selected as the drug delivery carrier,with the cancer therapeutic drug mercaptopurine(6-MP)and glucose oxidase(GOD)as the drug models,hyaluronic acid(HA)was used for protection and targeted delivery,which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA).This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome.Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity,which provides new possibilities for the development of more precise and effective treatment strategies.
