Divergence of gene expression and alter native splicing is a crucial driving force in the evolution of species;to date, however the molecular mechanism remains unclear. Hybrids of closely related species provide a sui...Divergence of gene expression and alter native splicing is a crucial driving force in the evolution of species;to date, however the molecular mechanism remains unclear. Hybrids of closely related species provide a suitable model to analyze allele-specific expressi on (ASE) and allele-specific alter native splicing (ASS). Analysis of ASE and ASS can uncover the differences in cis-regulatory elements between closely related species, while eliminating interferenee of trans-regulatory elements. Here, we provide a detailed characterization of ASE and ASS from 19 and 10 transcriptome datasets across five tissues from reciprocal-cross hybrids of horsex don key (mule/hi nny) and cattlexyak (dzo), respectively. Results showed that 4.8%-8.7% and 10.8%-16.7% of genes exhibited ASE and ASS, respectively. Notably, IncRNAs and pseudogenes were more likely to show ASE than protein-coding genes. In addition, genes showing ASE and ASS in mule/hinny were found to be involved in the regulation of muscle strength, whereas those of dzo were involved in high-altitude adaptati on. In con clusi on, our study dem on strated that explorati on of genes showing ASE and ASS in hybrids of closely related species is feasible for species evolution research.展开更多
A variety of existing image quality assessment （IQA） metrics share a similar two-stage framework： at the first stage, a quality map is constructed by comparison between local regions of reference and distorted imag...A variety of existing image quality assessment （IQA） metrics share a similar two-stage framework： at the first stage, a quality map is constructed by comparison between local regions of reference and distorted images; at the second stage, the spatial pooling is adopted to obtain overall quality score. In this work, we propose a novel spatial pooling strategy for image quality assessment through statistical analysis of the quality map. Our in-depth analysis indicates that the overall image quality is sensitive to the quality distribution. Based on the analysis, the quality histogram and statistical descriptors extracted from the quality map are used as input to the support vector regression to obtain the final objective quality score. Experimental results on three large public IQA databases have demonstrated that the proposed spatial pooling strategy can greatly improve the quality prediction performance of the original IQA metrics in terms of correlation with human subjective ratings.展开更多
基金supported by grants from the National Natural Science Foundation of China(31572381)National Thousand Youth Talents Plan of the International Science and Technology Cooperation Project of China(2013DFA31420)Science and Technology Innovation Capability Promotion Program of the Science and Technology Department of Qinghai Province(2015-ZJ-712)
文摘Divergence of gene expression and alter native splicing is a crucial driving force in the evolution of species;to date, however the molecular mechanism remains unclear. Hybrids of closely related species provide a suitable model to analyze allele-specific expressi on (ASE) and allele-specific alter native splicing (ASS). Analysis of ASE and ASS can uncover the differences in cis-regulatory elements between closely related species, while eliminating interferenee of trans-regulatory elements. Here, we provide a detailed characterization of ASE and ASS from 19 and 10 transcriptome datasets across five tissues from reciprocal-cross hybrids of horsex don key (mule/hi nny) and cattlexyak (dzo), respectively. Results showed that 4.8%-8.7% and 10.8%-16.7% of genes exhibited ASE and ASS, respectively. Notably, IncRNAs and pseudogenes were more likely to show ASE than protein-coding genes. In addition, genes showing ASE and ASS in mule/hinny were found to be involved in the regulation of muscle strength, whereas those of dzo were involved in high-altitude adaptati on. In con clusi on, our study dem on strated that explorati on of genes showing ASE and ASS in hybrids of closely related species is feasible for species evolution research.
基金This work was supported by the National Natural Science Foundation of China under Grant No. 61571212 and the Natural Science Foundation of Jiangxi Province of China under Grant No. 20151BDH80003.
文摘A variety of existing image quality assessment （IQA） metrics share a similar two-stage framework： at the first stage, a quality map is constructed by comparison between local regions of reference and distorted images; at the second stage, the spatial pooling is adopted to obtain overall quality score. In this work, we propose a novel spatial pooling strategy for image quality assessment through statistical analysis of the quality map. Our in-depth analysis indicates that the overall image quality is sensitive to the quality distribution. Based on the analysis, the quality histogram and statistical descriptors extracted from the quality map are used as input to the support vector regression to obtain the final objective quality score. Experimental results on three large public IQA databases have demonstrated that the proposed spatial pooling strategy can greatly improve the quality prediction performance of the original IQA metrics in terms of correlation with human subjective ratings.
