Research progress in the treatment of cardiovascular diseases based on mTOR regulating autophagy

Cardiovascular diseases(CVDs)is a major medical problem in the 21st century.Although the current treatments are rich and diverse,they have not achieved satisfactory results in prevention and treatment.The treatment of CVDS needs to find a wider and effective treatment target and direction.Autophagy is a metabolic process that degrades macromolecules.It can degrade damaged organelles,specific macromolecules,and invaded viruses and bacteria.Autophagy is widely involved in the body's metabolism and immunity,and is closely related to cardiovascular diseases.mammalian target of rapamycin(mTOR)is an atypical serine/threonine kinase,a major regulator of autophagy,can regulate the metabolism of cells and proteins in the body,and is widely involved in the occurrence and development of cardiovascular diseases.This article summarizes the relevant content of Chinese and Western medicine on mTOR regulation of autophagy in CVDS in recent years at home and abroad,in order to provide a reference for follow-up research.

Research progress of hypertension treatment based on hypertensive inflammatory response

The concept that hypertension is vascular inflammation has been widely recognized.A large number of experiments have been carried out in the past,but no relevant breakthroughs have been made in clinical application.At present,the drugs for clinical treatment of hypertension still take the previous pathogenesis of hypertension as the target,so the treatment of hypertension has not achieved satisfactory results.This article starts from the relationship between hypertension and inflammatory response,and integrates relevant research on the treatment of hypertension and inflammatory response by Chinese and Western medicine in the past three years,with a view to providing new directions and targets for the prevention and treatment of hypertension,so as to better control hypertension and Target organ damage.

Preparation of CuS/BiVO4 thin film and its efficacious photoelectrochemical performance in hydrogen generation

To drive photoelectrochemical water splitting on porous BiVO4 photoanode,we herein prepared a carnationlike CuS powder by hydrothermal method and then loaded it onto BiVO4 photoelectrode.Expectedly,the CuS/BiVO4 composite not only presents a higher photocurrent response value at 1.23 V versus RHE(reversible hydrogen electrode)than pure BiVO4 electrode under visible light irradiation,but also exhibits an excellent photoelectrochemical hydrogen production activity in comparison with either the BiVO4 or the CuS.The high ameliorated performance of CuS/BiVO4 composite may be due to the strong absorption of visible light and an effective abatement in combination of carriers.These results demonstrate an effective potential approach to design and construct efficient photoelectrochemical(PEC)systems.

Variations in length of stay among survived very preterm infants admitted to Chinese neonatal intensive care units

Background This study aimed to describe length of stay(LOS)to discharge and site variations among very preterm infants(VPIs)admitted to 57 Chinese neonatal intensive care units(NICUs)and to investigate factors associated with LOS for VPIs.Methods This retrospective multicenter cohort study enrolled all infants<32 weeks’gestation and admitted to 57 NICUs which had participated in the Chinese Neonatal Network,within 7 days after birth in 2019.Exclusion criteria included major congenital anomalies,NICU deaths,discharge against medical advice,transfer to non-participating hospitals,and missing discharge date.Two multivariable linear models were used to estimate the association of infant characteristics and LOS.Results A total of 6580 infants were included in our study.The overall median LOS was 46 days[interquartile range(IQR):35-60],and the median corrected gestational age at discharge was 36 weeks(IQR:35-38).LOS and corrected gestational age at discharge increased with decreasing gestational age.The median corrected gestational age at discharge for infants at 24 weeks,25 weeks,26 weeks,27-28 weeks,and 29-31 weeks were 41 weeks,39 weeks,38 weeks,37 weeks and 36 weeks,respectively.Significant site variation of LOS was identified with observed median LOS from 33 to 71 days in different hospitals.Conclusions The study provided concurrent estimates of LOS for VPIs which survived in Chinese NICUs that could be used as references for medical staff and parents.Large variation of LOS independent of infant characteristics existed,indicating variation of care practices requiring further investigation and quality improvement.