Relationship between uncertainty in illness,mood state and coping style in patients with temporomandibular disorders

Objective:To investigate the relationship between uncertainty in illness,mood state and coping style in patients with temporomandibular disorders(TMD)in the hospital,in order to identify nursing measures.Methods:Chinese versions of the Mishel Uncertainty In Illness Scale(MUIS),Brief Profile Of Mood States(BPOMS)and Medical Coping Modes Questionnaire(MCMQ)were used to assess uncertainty in illness,mood state and coping style,respectively,in 126 patients with TMD.Results:The total score of uncertainty in illness of the patients was 91.33±16.38,which was at middle level.The total score of mood state was 37.93±17.0.The order of coping style rated from high to low was confrontation(18.81±3.65),avoidance(15.44±4.26)and acceptance(10.41±5.04).Acceptance was positively correlated with uncertainty in illness(r=0.463,p<0.001),and mood state(r=0.187,p<0.05).Avoidance and confrontation were negatively correlated with uncertainty in illness and mood state(r=0.286,p<0.01),(r=0.175,p<0.05),(r=0.171,p<0.05),(r=0.221,p<0.01).Conclusions:Both uncertainty in illness and mood state were related to coping style.These data suggest that nurses should be trained to offer appropriate guidance to help decrease patients'uncertainty in illness and relieve their negative emotions.

Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release

It is of great importance to treat a bacterial-infected wound by a smart dressing capable of delivering antibiotics in a smart manner without causing drug resistance.The construction of smart release nanocontainers responsive to near-infrared(NIR)laser irradiation in an on-demand and stepwise way is a promising strategy for avoiding the emergence of multidrug-resistant bacteria.Here,we develop a hydrogel composite made of alginate and nanotubes with an efficient NIR-triggered release of rifampicin and outstanding antibacterial ability.This composite hydrogel is prepared through co-encapsulating antibacterial drug(rifampicin),NIR-absorbing dye(indocyanine green),and phase-change materials(a eutectic mixture of fatty acids)into halloysite nanotubes,followed by incorporation into alginate hydrogels,allowing the in-situ gelation at room temperature and maintaining the integrity of drug-loaded nanotubes.Among them,the eutectic mixture with a melting point of 39℃ serves as the biocompatible phase-change material to facilitate the NIR-triggered drug release.The resultant phase-change material gated-nanotubes exhibit a prominent photothermal efficiency with multistep drug release under laser irradiation.In an in vitro assay,composite hydrogel provides good antibacterial potency against Staphylococcus aureus,one of the most prevalent microorganisms of dangerous gas gangrene.A bacterial-infected rat full-thickness wound model demonstrates that the NIR-responsive composite hydrogel inhibits the bacteria colonization and suppresses the inflammatory response caused by bacteria,promoting angiogenesis and collagen deposition to accelerate wound regeneration.The NIR-responsive composite hydrogel has a great po-tential as an antibacterial wound dressing functionalized with controlled multistep treatment of the infected sites.

Accumulation of 1-deoxynojirimycin in silkworm,Bombyx mori L.

1-deoxynojirimycin (1-DNJ) contents in the silkworm,Bombyx mori,at different developmental stages and tissues were investigated by using reverse-phase high-performance liquid chromatography. The 1-DNJ contents of silkworm larvae change significantly with their developmental stages. The male larvae showed higher accumulation efficiency of 1-DNJ than the females and also a significant variation was observed among the silkworm strains. The present results show that tissue distribution of 1-DNJ was significantly higher in blood,digestive juice,and alimentary canal,but no 1-DNJ was observed in the silkgland. Moreover,1-DNJ was not found in silkworms fed with artificial diet that does not contain mulberry leaf powder. This proves that silkworms obtain 1-DNJ from mulberry leaves; they could not synthesize 1-DNJ by themselves. The accumulation and excretion of 1-DNJ change periodically during the larval stage. There was no 1-DNJ in the newly-hatched larvae and 1-DNJ was mainly accumulated during the early and middle stages of every instar,while excreted at later stages of larval development. Further,it is possible to extract 1-DNJ from the larval feces and it is optimal to develop the 1-DNJ related products for diabetic auxiliary therapy.

Non-fluoroscopic percutaneous transcatheter closure of atrial septal defects in children under transesophageal echocardiographic guidance

Background This study sought to investigate the feasibility, safety and effectiveness of transcatheter closure of atrial septal defects (ASDs) under the guidance of transesophageal echocardiography (TEE) in children. Methods We reviewed the medical records of patients who underwent percutaneous ASD closure at our center from August 2016 to December 2017. For a total of 88 patients who were identified as having a single-hole defect and were undergoing percutaneous transcatheter ASD closure, a procedure completely guided by TEE was performed. There were 31 male patients and 57 female patients. The patients' mean age was 60.09 ± 36.42 months (13–182 months), and their mean body weight was 20.16 ± 10.04 kg (9–77 kg). Patients were followed up by performing transthoracic echocardiography and obtaining chest X-rays and electrocardiograms. Results The transcatheter closure of ASDs was successful in all patients. The mean ASD size was 11.58 ± 5.31 mm (3–28 mm), and the mean size of the occlusion device was 16.07 ± 5.29 mm (6–36 mm). The mean procedural times were 13.33 ± 2.82 minutes (6–16 minutes). The mean hospitalization costs were 27,259.66 ± 2507.04 RMB (25,200.00–33,911.45 RMB). The mean postoperative hospital stay was 3.22 ± 0.53 days (3–5 days). Residual shunt, occlusion device shedding or displacement, and pericardial effusion were not observed during or after the operation. Conclusion Percutaneous transcatheter ASD closure completely guided by TEE is a feasible, safe, non-invasive and easy procedure.

Imaging findings of multiple infantile hepatic hemangioma associated with cardiac insufficiency

Background:Infantile hepatic hemangioma(IHH)as a benign liver tumor in infancy and childhood is commonly associated with high output cardiac failure.The present study aims to describe the imaging findings in a patient who was diagnosed as having multiple IHH with congestive cardiac insuffi ciency.Methods:The imaging findings and clinical manifestations of the patient with multiple IHH associated with cardiac insuffi ciency were retrospectively reviewed.Results:Ultrasonography showed multiple intrahepatic lesions with mixed echoes and markedly expanded hepatic veins and the inferior vena cava of the patient.Echocardiography revealed right heart insufficiency and pulmonary hypertension.Contrast-enhanced MRI showed early mild enhancement of lesions and more obvious delayed enhancement.The patient died after combined therapy of surgery and hormone.Conclusions:The imaging findings of multiple IHH associated with cardiac insufficiency are typical and diagnostic.Early imaging assessment may facilitate the diagnosis and treatment of the disease.