BACKGROUND Mucinous cystic neoplasm of the liver(MCN-L)is a cyst-forming epithelial neoplasm.The most distinguishing feature is the ovarian-type subepithelial stroma on pathological examination.CASE SUMMARY An abdomin...BACKGROUND Mucinous cystic neoplasm of the liver(MCN-L)is a cyst-forming epithelial neoplasm.The most distinguishing feature is the ovarian-type subepithelial stroma on pathological examination.CASE SUMMARY An abdominal ultrasound incidentally revealed a liver tumor in a 32-year-old woman.Physical and laboratory examination results did not reveal any abnormalities.Enhanced abdominal computed tomography(CT)revealed a cystic space measuring 7.2 cm×5.4 cm in the liver.Subsequent CT showed an increase in tumor size.Thus,we performed surgical resection of the tumor and gallbladder.Postoperative histopathological examination confirmed the diagnosis of MCN-L.At the 6-mo of follow-up,no recurrence was observed on ultrasound or CT.CONCLUSION Since preoperative diagnosis of MCN-L is difficult,active surgery is recommended and helpful for the diagnosis and treatment of MCN-L.展开更多
NO3 and N2O5 are important participants in nocturnal atmospheric chemical processes,and their concentrations are of great significance in the study of the mechanism of nocturnal atmospheric chemical reactions.A two-ch...NO3 and N2O5 are important participants in nocturnal atmospheric chemical processes,and their concentrations are of great significance in the study of the mechanism of nocturnal atmospheric chemical reactions.A two-channel diode laser based cavity ring-down spectroscopy(CRDS)instrument was developed to monitor the concentrations of NO3 and N2O5 in the atmosphere.The effective absorption length ratio and the total loss coefficient of the instrument were calibrated using laboratory standard samples.The effective absorption cross section of NO3 at 662 nm was derived.A detection sensitivity of 1.1 pptv NO3 in air was obtained at a time resolution of 1 s.N2O5 was converted to NO3 and detected online in the second CRDS channel.The instrument was used to monitor the concentrations of NO3 and N2O5 in the atmosphere of winter in Hefei in real time.By comparing the concentration changes of pollutants such as nitrogen oxides,ozone,PM2:5 in a rapid air cleaning process,the factors affecting the concentrations of NO3 and N2O5 in the atmosphere were discussed.展开更多
The divergence and continuous evolution of plants and animals contribute to ecological diversity.Promoters and transcription factors(TFs) are key determinants of gene regulation and transcription throughoutlife.Howeve...The divergence and continuous evolution of plants and animals contribute to ecological diversity.Promoters and transcription factors(TFs) are key determinants of gene regulation and transcription throughoutlife.However,theevolutionary trajectories and relationships of promoters and TFs are still poorly understood. Here, we conducted extensive analysis of large-scale multi-omics sequences in 420 animal species and 223 plant species spanning nearly a billion years of evolutionary history. Results showed that promoter GC-contentandTFisoelectricpoints,as features/signatures that accompany long biological evolution, exhibited increasing growth in animal cells but a decreasing trend in plant cells. Furthermore, the evolutionary trajectories of promoter and TF signatures in the animal kingdom provided further evidence that Mammalia as well as Aves evolved directly from the ancestor Reptilia. The strong correlation between promoter and TF signatures indicates that promoters and TFs formed antagonistic coevolution in the animal kingdom, but mutualistic coevolution in the plant kingdom. The distinct coevolutionary patterns potentially drive the plant-animal divergence, divergent evolution and ecological diversity.展开更多
Ultrafiltration and a series of chromatographic steps were used to isolate and purify polysaccharides from Tremella aurantialba fruit bodies.Three crude fractions(TAP50w,TAP10-50w,and TAP1-10w),five semi-purified frac...Ultrafiltration and a series of chromatographic steps were used to isolate and purify polysaccharides from Tremella aurantialba fruit bodies.Three crude fractions(TAP50w,TAP10-50w,and TAP1-10w),five semi-purified fractions(TAPA-TAPE),and one purified fraction(TAPA1) were obtained.A sulfated derivative of TAPA1(TAPA1-s) was prepared by chemical modification.The immunostimulating activity of the polysaccharide fractions in vitro was determined using the mouse spleen lymphocyte proliferation assay.Of the three crude fractions tested,cell prolifera-tion rates were increased most by TAP50w.Furthermore,TAPA1-s was markedly more stimulatory than TAPA1,indicating that sulfonation was an effective way to enhance the immunostimulating activity of polysaccharide.展开更多
基金Hebei Province Medical Science Research Key Project Plan,No.20160318.
文摘BACKGROUND Mucinous cystic neoplasm of the liver(MCN-L)is a cyst-forming epithelial neoplasm.The most distinguishing feature is the ovarian-type subepithelial stroma on pathological examination.CASE SUMMARY An abdominal ultrasound incidentally revealed a liver tumor in a 32-year-old woman.Physical and laboratory examination results did not reveal any abnormalities.Enhanced abdominal computed tomography(CT)revealed a cystic space measuring 7.2 cm×5.4 cm in the liver.Subsequent CT showed an increase in tumor size.Thus,we performed surgical resection of the tumor and gallbladder.Postoperative histopathological examination confirmed the diagnosis of MCN-L.At the 6-mo of follow-up,no recurrence was observed on ultrasound or CT.CONCLUSION Since preoperative diagnosis of MCN-L is difficult,active surgery is recommended and helpful for the diagnosis and treatment of MCN-L.
基金Hao Wu,Jian Chen,An-wen Liu,and Shui-ming Hu acknowledge the supports from the Ministry of Science and Technology of China(No.2013BAK12B00)the National Natural Science Foundation of China(No.21427804).
文摘NO3 and N2O5 are important participants in nocturnal atmospheric chemical processes,and their concentrations are of great significance in the study of the mechanism of nocturnal atmospheric chemical reactions.A two-channel diode laser based cavity ring-down spectroscopy(CRDS)instrument was developed to monitor the concentrations of NO3 and N2O5 in the atmosphere.The effective absorption length ratio and the total loss coefficient of the instrument were calibrated using laboratory standard samples.The effective absorption cross section of NO3 at 662 nm was derived.A detection sensitivity of 1.1 pptv NO3 in air was obtained at a time resolution of 1 s.N2O5 was converted to NO3 and detected online in the second CRDS channel.The instrument was used to monitor the concentrations of NO3 and N2O5 in the atmosphere of winter in Hefei in real time.By comparing the concentration changes of pollutants such as nitrogen oxides,ozone,PM2:5 in a rapid air cleaning process,the factors affecting the concentrations of NO3 and N2O5 in the atmosphere were discussed.
基金supported by the National Key Research and Development Program of China (2017YFA0505500 to L.N.C., 2017YFC0909502 to J.S.Z.)Strategic Priority Research Program of the Chinese Academy of Sciences (XDB38040400 to L.N.C., XDB13000000 to W.W.)+3 种基金National Science Foundation of China (12131020 and 31930022 to L.N.C, 61602460 to J.S.Z.)Major Key Project of PCL (PCL2021A12 to L.N.C.)Special Fund for Science and Technology Innovation Strategy of Guangdong Province(2021B0909050004 and 2021B0909060002 to L.N.C.)Fundamental Research Funds for the Central Universities(3102019JC007 to W.W.)。
文摘The divergence and continuous evolution of plants and animals contribute to ecological diversity.Promoters and transcription factors(TFs) are key determinants of gene regulation and transcription throughoutlife.However,theevolutionary trajectories and relationships of promoters and TFs are still poorly understood. Here, we conducted extensive analysis of large-scale multi-omics sequences in 420 animal species and 223 plant species spanning nearly a billion years of evolutionary history. Results showed that promoter GC-contentandTFisoelectricpoints,as features/signatures that accompany long biological evolution, exhibited increasing growth in animal cells but a decreasing trend in plant cells. Furthermore, the evolutionary trajectories of promoter and TF signatures in the animal kingdom provided further evidence that Mammalia as well as Aves evolved directly from the ancestor Reptilia. The strong correlation between promoter and TF signatures indicates that promoters and TFs formed antagonistic coevolution in the animal kingdom, but mutualistic coevolution in the plant kingdom. The distinct coevolutionary patterns potentially drive the plant-animal divergence, divergent evolution and ecological diversity.
基金Project (No.2006BAD06B08) supported by the National Key Technology R & D Program of China
文摘Ultrafiltration and a series of chromatographic steps were used to isolate and purify polysaccharides from Tremella aurantialba fruit bodies.Three crude fractions(TAP50w,TAP10-50w,and TAP1-10w),five semi-purified fractions(TAPA-TAPE),and one purified fraction(TAPA1) were obtained.A sulfated derivative of TAPA1(TAPA1-s) was prepared by chemical modification.The immunostimulating activity of the polysaccharide fractions in vitro was determined using the mouse spleen lymphocyte proliferation assay.Of the three crude fractions tested,cell prolifera-tion rates were increased most by TAP50w.Furthermore,TAPA1-s was markedly more stimulatory than TAPA1,indicating that sulfonation was an effective way to enhance the immunostimulating activity of polysaccharide.
