Effect of rapid rehabilitation nursing on improving clinical outcomes in postoperative patients with colorectal cancer

BACKGROUND Surgical resection is the cornerstone treatment for colorectal cancer.Rapid rehabilitation care predicated on evidence-based medical theory aims to improve postoperative nursing care,subsequently reducing the physical and mental traumatic stress response and helping patients who undergo surgery recover rapidly.AIM To assess the effect of rapid rehabilitation care on clinical outcomes,including overall postoperative complications,anastomotic leaks,wound infections,and intestinal obstruction in patients with colorectal cancer.METHODS We searched the PubMed,Web of Science,Embase,Elsevier Science Direct,and Springer Link databases from January 1,2010,to January 1,2024,to screen eligible studies on rapid rehabilitation care among patients who underwent colorectal cancer surgery.Patients were screened based on the inclusion and exclusion criteria.RevMan 5.4 software was used for statistical analysis of the data.RESULTS Twelve studies were enrolled,which included 2420 patients.The results showed that rapid rehabilitation care decreased the incidence of overall postoperative complications(OR:0.44,95%CI:0.26–0.74,P=0.002),anastomotic leaks(OR:0.68,95%CI:0.41–1.12,P=0.13),wound infections(OR:0.45,95%CI:0.29–0.72,P=0.0007),and intestinal obstruction(OR:0.54,95%CI:0.34–0.86,P=0.01)compared to conventional care.Further trials and studies are needed to confirm these results.CONCLUSION Rapid rehabilitation care decreased the occurrence of postoperative complications,anastomotic leaks,wound infections,and intestinal obstruction compared to conventional care in patients who underwent colorectal surgery.Therefore,promoting the application of rapid rehabilitation care in clinical practice cannot be overemphasized.

A clinical protocol: A double-blinded, randomized controlled trial on the effect of traditional Chinese medicine formula Shoutai Pill in the treatment of threatened abortion

for about 20%of all clinically confirmed pregnancy.It is the main cause of early abortion.Vaginal bleeding is the main clinical manifestation,which seriously affects the mental health and quality of life of pregnant women.Currently,there is effective treatment for this condition.A recent meta-analysis showed that Shoutai Pill(ST Pill),a traditional Chinese medicine(TCM)formula,can effectively decrease the rate of threatened abortion.However,high heterogeneity was found among the studies included in the meta-analysis,this conclusion on the efficacy of TCM is not definitive.Although several have been conducted,some of them do not describe randomization and blinding methods.To address these problems,this article proposes an improved clinical treatment scheme based on ST Pill,which is to be tested through a well-designed randomized controlled trial,for the treatment of threatened abortion.Methods:This is a double-blinded,randomized,placebo-controlled trial to be conducted in a public Three-A hospital in China's Mainland.A total of 200 people will be enrolled.Using computer-generated random numbers,the participants will be randomly divided into two groups at a ratio of 1:1(treatment group(treated with ST Pill group)and placebo group).Both groups will receive medication to the end of the 20th gestational week or 1 week after vaginal bleeding stops,depending on which is longer.Participants in the treatment group will be treated with ST Pill(20 pills/time,once a day),and those in the placebo group will receive a placebo drug which is similar in appearance and smell with ST Pill.The main observation index is the live birth rate.Discussion:Although the efficacy of ST Pill in threatened abortion is well-known,no study has tested its efficacy through a double-blinded,randomized trials.Therefore,there is an urgent need for a standardized randomized double-blinded controlled trial to evaluate the clinical efficacy of ST Pill.ST Pill is likely to be a convenient and effective TCM pill for the prevention of threatened abortion.

Analysis of the relationship between liver-qi stagnation and premature ovarian failure based on exosomes

The incidence of premature ovarian failure,which is related to women’s excessive pressure and mental tension,has increased in recent years.Premature ovarian failure has become one of the diseases that seriously disturb women’s physical and mental health,and its incidence can be regarded as liver depression and qi stagnation.Patients have an increasing demand for treatment,not only for fertility with the improvement of social living standards and the development of healthcare technology.Exosomes,as small membrane vesicles containing complex RNA and proteins,have the function of mediating cell communication and transmitting information in the pathological state caused by liver-qi stagnation.Exosomes in the hypoxic microenvironment can protect cells from damage and promote the pathological process.Moreover,exosomes in an inflammatory environment can play an active anti-inflammatory role.Exosomes can reduce the apoptosis of granulosa cells by expressing miRNA and so on to restore ovarian function.The purpose of treating premature ovarian failure can be achieved in this way.This paper introduced the relationship between the three,discussed the guiding significance of Chinese medicine theories in the treatment of exosomes and premature ovarian failure,and provided new research ideas for the treatment of integrated traditional Chinese medicine and western medicine.

Dynamic modeling of a 6-degree-of-freedom Stewart platform driven by a permanent magnet synchronous motor

For an electrical six-degree-of-freedom Stewart platform,it is difficult to compute the equivalent inertia of each motor in real time,as the inertia is time-varying.In this study,an analysis using Kane's equation is undertaken of the driven torque of the movements of motor systems(including motor friction,movements of motor systems along with the actuators,rotation around axis of rotors and snails),as well as driven torque of the platform and actuators.The electromagnetic torque was calculated according to vector-controlled permanent magnet synchronous motor(PMSM) dynamics.By equalizing the driven torque and electromagnetic torque,a model was established.This method,taking into consideration the influence of counter electromotive force(EMF) and motor friction,could be applied to the real-time dynamic control of the platform,through which the calculation of the time-varying equivalent inertia is avoided.Finally,simulations with typically desired trajectory inputs are presented and the performance of the Stewart platform is determined.With this approach,the multi-body dynamics of the electrical Stewart platform is better understood.

Effect of Weight Loss on In Vitro Fertilization Treatment Outcome

Background:To assess the effect of weight loss in overweight and/or obese women on the in vitro fertilization(IVF)treatment outcome before IVF cycles by a systematic review and meta-analysis of clinical trials.Methods:Systematic review and meta-analysis of randomized controlled trials(RCTs)and cohort studies were conducted.Systematic literature searches were conducted,and all randomized trials that evaluated the impact of weight loss in IVF treatment cycles were included in the study.Study selection,quality estimation,and data extractions were performed independently and in duplicate.Results:A total of 924 patients were enrolled in seven studies;the effects of weight loss on the IVF treatment outcome before the IVF treatment cycle were assessed.The clinical pregnancy rate(risk ratio[RR]:1.61,95%confidence interval[CI]:1.15-2.27),miscarriage rate(RR:0.56,95%CI:0.34-0.93),and live birth rate(RR:1.86,95%CI:1.41-2.45)had a statistically significant difference between the intervention and control group.No significant differences were observed in the number of oocytes retrieved(weighted mean difference[WMD]:0.84,95%CI:−0.12-1.79),gonadotropin consumption(WMD:2.59,95%CI:−6.61-1.42),or the duration of stimulation(WMD:−0.46,95%CI:−1.64-0.71).Conclusions:Before IVF treatment,obese and overweight women should lose weight by physical activity and/or dietary management because weight loss can improve pregnancy rate,reduce miscarriage rate,and meliorate live birth rate.At the same time,further prospective RCTs are required to establish which methods of weight loss are most suited to this purpose,as well as determining whether cut points for body mass index need to be recommended before accessing IVF.