Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and sy...Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 Ma and 432 ± 4 Ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline series.Both are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.展开更多
AIM To compare the capacity of newly developed epidermal growth factor receptor(EGFR)-targeted immune magnetic liposomes(EILs) vs epithelial cell adhesion molecule(Ep CAM) immunomagnetic beads to capture colorectal ci...AIM To compare the capacity of newly developed epidermal growth factor receptor(EGFR)-targeted immune magnetic liposomes(EILs) vs epithelial cell adhesion molecule(Ep CAM) immunomagnetic beads to capture colorectal circulating tumor cells(CTCs).METHODS EILs were prepared using a two-step method, and the magnetic and surface characteristics were confirmed. The efficiency of capturing colorectal CTCs as well as the specificity were compared between EILs and Ep CAM magnetic beads. RESULTS The obtained EILs had a lipid nanoparticle structure similar to cell membrane. Improved binding with cancer cells was seen in EILs compared with the method of coupling nano/microspheres with antibody. The binding increased as the contact time extended. Compared with Ep CAM immunomagnetic beads, EILs captured more CTCs in peripheral blood from colorectal cancer patients. The captured cells showed consistency with clinical diagnosis and pathology. Mutation analysis showed same results between captured CTCs and cancer tissues. CONCLUSION EGFR antibody-coated magnetic liposomes show high efficiency and specificity in capturing colorectal CTCs.展开更多
Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting paper.Three plant species namely Broussonetia kazinoki,Broussone...Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting paper.Three plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and papermaking.Their chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular weight.The yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were determined.Optical microscope was used to characterize the fiber length-width ratio and rigidity.Finally,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber rigidity.This study demonstrates the high potentiality of these three species for papermaking applications.展开更多
Psoriasis is a systemic immune-mediated inflammatory disease that presents at any age and is characterized by excessive proliferation and abnormal differentiation of keratinocytes as well as infiltration of multiple i...Psoriasis is a systemic immune-mediated inflammatory disease that presents at any age and is characterized by excessive proliferation and abnormal differentiation of keratinocytes as well as infiltration of multiple inflammatory cells.It has been gradually attracting more attention because of not only the increased risk of cardiovascular,metabolic,and autoimmune-related diseases but also the accompanying depression,anxiety,self-affirmation impairments,dementia,sleep disorders,and other mental disorders that place a substantial psychosocial burden on society and individuals.Mental and psychological disorders are involved in the occurrence,development,outcome,recurrence,and treatment of psoriasis through the neuroendocrine-immune signaling network.This review summarizes the pathogenesis of psychological and psychological disorders in patients with psoriasis with the aim of deepening clinicians’awareness of the mental and psychiatric comorbidities in patients with psoriasis.展开更多
In this paper,the theory of"Fear injury kidney"in traditional Chinese Medicine is systematically reviewed,and it is found that long-term or excessive psychological changes of fear are likely to damage kidney...In this paper,the theory of"Fear injury kidney"in traditional Chinese Medicine is systematically reviewed,and it is found that long-term or excessive psychological changes of fear are likely to damage kidney qi and kidney essence.On this basis,the psychological studies of patients,medical staff and the public during the COVID-19 epidemic in China were analyzed,and fear psychology was found to be prevalent among all kinds of people.Modern researches on"Fear injury kidney"have also found that long-term or excessive fear could cause changes in the neuro-endocrine-immune system,which can induce diseases or susceptibility to some diseases.Therefore,during or after the prevalence of COVID-19,different groups of people may have emotional reactions such as stress and fear,which should be paid long-term attention,and the influence of fear on the body cannot be ignored.According to the change rule of psychological state under stress reaction,we should actively respond to and take psychological crisis intervention measures in time to reduce the harm of psychological stress to the body.展开更多
A series of thermal compression tests on a CrMn-Si-Ni alloyed naval steel were carried out at different strain rates(0.0005-0.0100 s^(-1)) at different temperatures(1023-1173 K).Based on the friction-corrected data ob...A series of thermal compression tests on a CrMn-Si-Ni alloyed naval steel were carried out at different strain rates(0.0005-0.0100 s^(-1)) at different temperatures(1023-1173 K).Based on the friction-corrected data obtained from the compression tests,strain-compensated Arrhenius-type constitutive(SCAC) and backpropagation artificial neural network(BP-ANN) models with the optimized structure of the Cr-Mn-Si-Ni alloyed naval steel were established.The optimized BP-ANN model,where the operation time and overfitting of BP-ANN were shortened and avoided,respectively,exhibited improved predictive performance.The two models were assessed further in terms of the correlation coefficient(R),average absolute relative error,and root mean square error.The results validated that the optimized BP-ANN model predicted the flow behavior of the Cr-Mn-Si-Ni alloyed naval steel better than the SC AC model.The effect of the forming temperature and strain rate on the microstructural evolution behavior of the naval steel during thermoplastic deformation was investigated through the electron backscatter diffraction analysis of the compressed samples.It was observed that the dynamic recrystallization of the naval steel was promoted by an increase in the forming temperature and a decrease in the strain rate during thermoplastic deformation.展开更多
基金funded by Gansu Provincial Natural Science Foundation (Grant Numbers 21JR7RA503 and22JR5RA819)the Fundamental Research Funds for the Central Universities (Grant lzujbky-2021-ct07)+1 种基金the Key Talent Project of Gansu Province (2022-Yangzhenxi)the National Second Expedition to the Tibetan Plateau (2019QZKK0704)。
文摘Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 Ma and 432 ± 4 Ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline series.Both are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.
文摘AIM To compare the capacity of newly developed epidermal growth factor receptor(EGFR)-targeted immune magnetic liposomes(EILs) vs epithelial cell adhesion molecule(Ep CAM) immunomagnetic beads to capture colorectal circulating tumor cells(CTCs).METHODS EILs were prepared using a two-step method, and the magnetic and surface characteristics were confirmed. The efficiency of capturing colorectal CTCs as well as the specificity were compared between EILs and Ep CAM magnetic beads. RESULTS The obtained EILs had a lipid nanoparticle structure similar to cell membrane. Improved binding with cancer cells was seen in EILs compared with the method of coupling nano/microspheres with antibody. The binding increased as the contact time extended. Compared with Ep CAM immunomagnetic beads, EILs captured more CTCs in peripheral blood from colorectal cancer patients. The captured cells showed consistency with clinical diagnosis and pathology. Mutation analysis showed same results between captured CTCs and cancer tissues. CONCLUSION EGFR antibody-coated magnetic liposomes show high efficiency and specificity in capturing colorectal CTCs.
基金supported by the National Key R&D Program of China(No.2022YFF0904501)Shanghai Rising-Star Program(No.23QA1404100)。
文摘Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting paper.Three plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and papermaking.Their chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular weight.The yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were determined.Optical microscope was used to characterize the fiber length-width ratio and rigidity.Finally,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber rigidity.This study demonstrates the high potentiality of these three species for papermaking applications.
基金supported by the National Natural Science Foundation of China(Nos.81974475,82173423)Shenzhen Basic Research Project(Natural Science Foundation)Basic Research Project(No.JCYJ20190809103805589)+1 种基金Shenzhen Nanshan District Science and Technology Project/Key Project(Nos.2019003,2022116)Nanshan District health system Science and Technology Major Project(Nos.NSZD2023007,NSZD2023051).
文摘Psoriasis is a systemic immune-mediated inflammatory disease that presents at any age and is characterized by excessive proliferation and abnormal differentiation of keratinocytes as well as infiltration of multiple inflammatory cells.It has been gradually attracting more attention because of not only the increased risk of cardiovascular,metabolic,and autoimmune-related diseases but also the accompanying depression,anxiety,self-affirmation impairments,dementia,sleep disorders,and other mental disorders that place a substantial psychosocial burden on society and individuals.Mental and psychological disorders are involved in the occurrence,development,outcome,recurrence,and treatment of psoriasis through the neuroendocrine-immune signaling network.This review summarizes the pathogenesis of psychological and psychological disorders in patients with psoriasis with the aim of deepening clinicians’awareness of the mental and psychiatric comorbidities in patients with psoriasis.
基金Supported by the National Key Research and Development Program of China:"Modernization Research of Traditional Chinese Medicine"Key Special Project:2019YFC1710100。
文摘In this paper,the theory of"Fear injury kidney"in traditional Chinese Medicine is systematically reviewed,and it is found that long-term or excessive psychological changes of fear are likely to damage kidney qi and kidney essence.On this basis,the psychological studies of patients,medical staff and the public during the COVID-19 epidemic in China were analyzed,and fear psychology was found to be prevalent among all kinds of people.Modern researches on"Fear injury kidney"have also found that long-term or excessive fear could cause changes in the neuro-endocrine-immune system,which can induce diseases or susceptibility to some diseases.Therefore,during or after the prevalence of COVID-19,different groups of people may have emotional reactions such as stress and fear,which should be paid long-term attention,and the influence of fear on the body cannot be ignored.According to the change rule of psychological state under stress reaction,we should actively respond to and take psychological crisis intervention measures in time to reduce the harm of psychological stress to the body.
基金financially supported by the National Natural Science Foundation of China (No.51975071)the Venture & Innovation Support Program for Chongqing Overseas ReturneesFundamental Research Funds for the Central Universities (No.2021CDJKYJH0001)。
文摘A series of thermal compression tests on a CrMn-Si-Ni alloyed naval steel were carried out at different strain rates(0.0005-0.0100 s^(-1)) at different temperatures(1023-1173 K).Based on the friction-corrected data obtained from the compression tests,strain-compensated Arrhenius-type constitutive(SCAC) and backpropagation artificial neural network(BP-ANN) models with the optimized structure of the Cr-Mn-Si-Ni alloyed naval steel were established.The optimized BP-ANN model,where the operation time and overfitting of BP-ANN were shortened and avoided,respectively,exhibited improved predictive performance.The two models were assessed further in terms of the correlation coefficient(R),average absolute relative error,and root mean square error.The results validated that the optimized BP-ANN model predicted the flow behavior of the Cr-Mn-Si-Ni alloyed naval steel better than the SC AC model.The effect of the forming temperature and strain rate on the microstructural evolution behavior of the naval steel during thermoplastic deformation was investigated through the electron backscatter diffraction analysis of the compressed samples.It was observed that the dynamic recrystallization of the naval steel was promoted by an increase in the forming temperature and a decrease in the strain rate during thermoplastic deformation.
