Prof.Xie Zichu passed away on January 25,2020 in Changsha,Hunan Province,China at the age of 83 years old.Being one of the internationally renowned and highly respected glaciologists of China,this issue is dedicated w...Prof.Xie Zichu passed away on January 25,2020 in Changsha,Hunan Province,China at the age of 83 years old.Being one of the internationally renowned and highly respected glaciologists of China,this issue is dedicated with all respect in memory of him for his life-long effort and contribution to advance studies on glaciology in China.He has undertaken field investigations on glacier mass balance.展开更多
Sensitive and specific bioassays of tumor markers are critical for early cancer detection and treatment.In recent years,lanthanide(Ln3+)doped upconversion nanoparticles(UCNPs)have attracted wide attentions in tumor ma...Sensitive and specific bioassays of tumor markers are critical for early cancer detection and treatment.In recent years,lanthanide(Ln3+)doped upconversion nanoparticles(UCNPs)have attracted wide attentions in tumor markers detectio n.Herein,we co mbined NaYF4:Yb,Tm and silver nanoparticles,serving as energy donor and receptor,respectively,to form an up-conversion fluorescence based inhibitory tumor marker biosensor system.The tumor marker CA-125 molecules are labeled with silver NPs,and the energy transfer fluorescent signal can be detected between the UCNPs and the silver NP receptors.The biosensor shows good stability,high sensitivity and selectivity in the tumor marker concentration range from 5 to 100 ng/mL,as well as a detection limit of 120 pg/mL.Due to the advantage of ease of fabrication and operation,low cost and high information capacity,this technology holds great potential for the clinical applications.展开更多
文摘Prof.Xie Zichu passed away on January 25,2020 in Changsha,Hunan Province,China at the age of 83 years old.Being one of the internationally renowned and highly respected glaciologists of China,this issue is dedicated with all respect in memory of him for his life-long effort and contribution to advance studies on glaciology in China.He has undertaken field investigations on glacier mass balance.
基金Project supported by the National Key Research and Development Program(2016YFC0207101)the National Natural Science Foundation of China(61775080,81602659,11704056)the Natural Science Foundation of Jilin Province,China(20170101170JC)
文摘Sensitive and specific bioassays of tumor markers are critical for early cancer detection and treatment.In recent years,lanthanide(Ln3+)doped upconversion nanoparticles(UCNPs)have attracted wide attentions in tumor markers detectio n.Herein,we co mbined NaYF4:Yb,Tm and silver nanoparticles,serving as energy donor and receptor,respectively,to form an up-conversion fluorescence based inhibitory tumor marker biosensor system.The tumor marker CA-125 molecules are labeled with silver NPs,and the energy transfer fluorescent signal can be detected between the UCNPs and the silver NP receptors.The biosensor shows good stability,high sensitivity and selectivity in the tumor marker concentration range from 5 to 100 ng/mL,as well as a detection limit of 120 pg/mL.Due to the advantage of ease of fabrication and operation,low cost and high information capacity,this technology holds great potential for the clinical applications.
