Identifying human body states by using a flexible integrated sensor

Flexible sensors are required to be lightweight,compatible with the skin,sufficiently sensitive,and easily integrated to extract various kinds of body vital signs during continuous healthcare monitoring in daily life.For this,a simple and low-cost flexible temperature and force sensor that uses only two carbon fiber beams as the sensing layer is reported in this work.This simple,flexible sensor can not only monitor skin temperature changes in real time but can also extract most pulse waves,including venous waves,from most parts of the human body.A pulse diagnostic glove containing three such flexible sensors was designed to simulate pulse diagnostic methods used in traditional Chinese medicine.Wearable equipment was also designed in which four flexible sensors were fixed onto different body parts(neck,chest,armpit,and fingertip)to simultaneously monitor body temperature,carotid pulse,fingertip artery pulse,and respiratory rate.Four important physiological indicators—body temperature(BT),blood pressure(BP),heart rate(HR),and respiratory rate(RR)—were extracted by the wearable equipment and analyzed to identify exercise,excited,tired,angry,and frightened body states.

Fiber-junction design for directional bending sensors

Flexible sensors in wearable electronics have become increasingly multifunctional due to the development of materials synthesis and structure design.In particular,structural design can not only add capabilities to sensors fabricated from existing available and normal materials,but also offer opportunities for the fabrication of sensors with certain desired functions.Here,we designed a series of fiber-junction structure models,in which two fibers were simply hooked to each other to form a junction on a flexible printed circuit,for fabrication of directional bending sensors.The value and direction of bending angle are related to the change in electronic signal by a theoretical expression,allowing us to employ a simple and practicable method to use available conductive fiber materials to fabricate high-sensitivity,high-resolution and directional bending sensors.In addition,these models are generally applicable,which have broad combination with different conductive fiber,and corresponding bending sensors all possess capability of directional identification.Furthermore,the capability of identifying directional bending was demonstrated by human motion monitoring such as joint bending and muscle contraction.

钆塞酸二钠增强磁共振成像肝胆期对比剂摄取相关参数评估药物性肝损伤的价值

目的探讨钆塞酸二钠(Gd-EOB-DTPA)增强磁共振成像(MRI)肝胆期对比剂摄取相关参数评估药物性肝损伤(DILI)患者肝损伤程度的价值。方法选择2020年1月至2021年6月扬州大学附属苏北人民医院收治的55例DILI患者,其中轻症DILI组29例,重症DILI组26例。选择同期30例肝功能正常患者(非DILI组)作为对照。回顾性分析患者Gd-EOB-DTPA增强MRI图像,测量增强前及增强后肝胆期肝脏、门静脉与脾脏信号强度,计算肝脏相对强化程度(RE)、肝脏相对于门静脉强化程度比(LPC)、肝脏相对于脾脏强化程度比(LSC),同时评价功能性肝脏影像评分(FLIS)。比较非DILI组、轻症DILI组、重症DILI组患者各参数差异。采用Pearson相关分析Gd-EOB-DTPA增强MRI肝胆期对比剂摄取相关参数与肝功能指标的相关性。绘制受试者操作特征(ROC)曲线分析Gd-EOB-DTPA增强MRI肝胆期对比剂摄取相关参数鉴别轻症DILI组与重症DILI组的效能。结果DILI组患者RE、LPC、LSC均低于非DILI组患者,且随着肝损伤程度的加重而降低,且差异均有统计学意义(P均<0.05)。RE、LPC与DILI患者总胆红素水平呈中度负相关(r=-0.53、-0.51,P<0.05),与DILI患者总蛋白水平呈中度正相关(r=0.54、0.53,P<0.05)。ROC曲线显示,RE、LPC、LSC、FLIS区分轻症DILI组与重症DILI组患者的曲线下面积(AUC)分别为0.74、0.81、0.74、0.78。结论Gd-EOB-DTPA增强MRI肝胆期对比剂摄取相关参数可评估DILI患者肝损伤程度,为临床定量评估DILI严重程度提供了新的辅助方法。