Cough is a defensive behavior that protects the respiratory system from infection and clears airway secretions.Cough airflow dynamics have been analyzed by a variety of mathematical and experimental tools.In this pape...Cough is a defensive behavior that protects the respiratory system from infection and clears airway secretions.Cough airflow dynamics have been analyzed by a variety of mathematical and experimental tools.In this paper,the cough airflow dynamics of 42 subjects were obtained and analyzed.An identification model based on piecewise Gauss function for cough airflow dynamics is proposed through the dimensionless method,which could achieve over 90%identification accuracy.Meanwhile,an assisted cough system based on pneumatic flow servo system is presented.The vacuum situation and feedback control are used to increase the simulated peak cough flow rate,which are important for airway secretion clearance and to avoid airway collapse,respectively.The simulated cough peak flow could reach 5 L/s without the external assistance such as manual pressing,patient cooperation and other means.Finally,the backstepping control is developed to generate a simulated cough airflow that closely mimics the natural cough airflow of humans.The assisted cough system opens up wide opportunities of practical application in airway secretion clearance for critically ill patients with COVID 2019 and other pulmonary diseases.展开更多
基金The research is supported by the National Natural Science Foundation of China(No.52005015)the China Postdoctoral Science Foundation(No.2019M660391)+2 种基金the Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems(No.GZKF-201920)the Outstanding Young Scientists in Beijing(No.BJJWZYJH01201910006021)the National Key Research and Development Project(No.2019YFC0121702).
文摘Cough is a defensive behavior that protects the respiratory system from infection and clears airway secretions.Cough airflow dynamics have been analyzed by a variety of mathematical and experimental tools.In this paper,the cough airflow dynamics of 42 subjects were obtained and analyzed.An identification model based on piecewise Gauss function for cough airflow dynamics is proposed through the dimensionless method,which could achieve over 90%identification accuracy.Meanwhile,an assisted cough system based on pneumatic flow servo system is presented.The vacuum situation and feedback control are used to increase the simulated peak cough flow rate,which are important for airway secretion clearance and to avoid airway collapse,respectively.The simulated cough peak flow could reach 5 L/s without the external assistance such as manual pressing,patient cooperation and other means.Finally,the backstepping control is developed to generate a simulated cough airflow that closely mimics the natural cough airflow of humans.The assisted cough system opens up wide opportunities of practical application in airway secretion clearance for critically ill patients with COVID 2019 and other pulmonary diseases.
