[Objectives]To study the clinical effect of Chaigui decoction(CGD)on Jueyin type hypertension based on the theory of Five Yun Six Qi.[Methods]52 patients with Jueyin type hypertension in Wuxi Hospital Affiliated to Na...[Objectives]To study the clinical effect of Chaigui decoction(CGD)on Jueyin type hypertension based on the theory of Five Yun Six Qi.[Methods]52 patients with Jueyin type hypertension in Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine from January,2020 to March,2021 were randomly divided into Western medicine control group(18 cases)and CGD group(34 cases).CGD group was treated with CGD,while the control group was treated with irbesartan or amlodipine.[Results]After treatment,the systolic blood pressure(SBP)of the two groups decreased significantly,the difference was statistically significant(P<0.05).After treatment,the diastolic blood pressure(DBP)of CGD group was significantly lower than that of the control group(P<0.05).[Conclusions]Based on the theory of Five Yun Six Qi,CGD has significant effect on Jueyin type hypertension,and the effect of reducing DBP is better than that of Western medicine control group.展开更多
L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercial...L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercially available and inexpensive D-sugars is highly desirable from the viewpoints of organic synthesis and drug discovery.As demonstrated by the convenient preparation of L-glucosyl,L-galactosyl,and L-mannosyl fluorides from readily availableβ-D-C-glucosyl,β-D-C-mannosyl,andβ-D-C-galactosyl derivatives,we describe a novel and efficient approach to the demanding L-glycosyl fluorides.展开更多
基金Fund of Wuxi Municipal Health Commission top young and middle-aged talents funding scheme(BJ2020064).
文摘[Objectives]To study the clinical effect of Chaigui decoction(CGD)on Jueyin type hypertension based on the theory of Five Yun Six Qi.[Methods]52 patients with Jueyin type hypertension in Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine from January,2020 to March,2021 were randomly divided into Western medicine control group(18 cases)and CGD group(34 cases).CGD group was treated with CGD,while the control group was treated with irbesartan or amlodipine.[Results]After treatment,the systolic blood pressure(SBP)of the two groups decreased significantly,the difference was statistically significant(P<0.05).After treatment,the diastolic blood pressure(DBP)of CGD group was significantly lower than that of the control group(P<0.05).[Conclusions]Based on the theory of Five Yun Six Qi,CGD has significant effect on Jueyin type hypertension,and the effect of reducing DBP is better than that of Western medicine control group.
基金support from the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2022QNLM030003-2)the National Natural Science Foundation of China(Nos.21977088 and 21672194)the National Natural Science Foundation of China-Shandong Joint Fund(No.U1906213)。
文摘L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercially available and inexpensive D-sugars is highly desirable from the viewpoints of organic synthesis and drug discovery.As demonstrated by the convenient preparation of L-glucosyl,L-galactosyl,and L-mannosyl fluorides from readily availableβ-D-C-glucosyl,β-D-C-mannosyl,andβ-D-C-galactosyl derivatives,we describe a novel and efficient approach to the demanding L-glycosyl fluorides.
