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短链脂肪酸对小鼠缺血再灌注肾损伤的炎症及纤维化影响和作用机制研究
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作者 孙婧婷 李娜 +3 位作者 罗明辉 高瑶瑶 白义行 朱国贞 《中华肾病研究电子杂志》 2024年第4期181-187,共7页
目的探讨短链脂肪酸(SCFAs)对小鼠肾损伤后炎症及纤维化的影响及其作用机制。方法采用双侧肾动脉夹闭25 min诱导缺血再灌注(I/R)肾损伤建立小鼠肾脏纤维化模型后,小鼠随机分为缺血再灌注组(I/R组)、短链脂肪酸组(I/R+SCFAs组)和短链脂... 目的探讨短链脂肪酸(SCFAs)对小鼠肾损伤后炎症及纤维化的影响及其作用机制。方法采用双侧肾动脉夹闭25 min诱导缺血再灌注(I/R)肾损伤建立小鼠肾脏纤维化模型后,小鼠随机分为缺血再灌注组(I/R组)、短链脂肪酸组(I/R+SCFAs组)和短链脂肪酸合并抗CD25单克隆抗体组(I/R+SCFAs+anti-CD25组),并设假手术组(Sham组),每组6只。I/R+SCFAs组和I/R+SCFAs+anti-CD25组小鼠在术前1周连续饮用SCFAs溶液,且I/R+SCFAs+anti-CD25组小鼠在术前2 d和手术当天给予腹腔注射anti-CD25;Sham组小鼠只分离肾动脉不进行夹闭。建模28 d后收集各组小鼠肾组织,进行病理学检测,免疫组织化学检测CD68、肿瘤坏死因子-α(TNF-α)、细胞间黏附分子-1(ICAM-1)、叉头盒转录因子P3(Foxp3)和转录因子维甲酸相关孤儿受体γt(RORγt)的表达,Western印迹检测各组肾组织中Toll样受体4(TLR4)、髓样分化因子88(MyD88)和核转录因子κB p65(NF-κB p65)及α-平滑肌肌动蛋白(α-SMA)等蛋白表达水平。结果与Sham组相比,I/R组小鼠病理损伤较重,肾小管间质纤维化增多,免疫组织化学检测显示肾组织CD68、TNF-α、ICAM-1表达显著升高(P均<0.05),Western印迹检测TLR4、MyD88、NF-κB p65、α-SMA蛋白表达水平显著增多(P均<0.05)。与I/R组相比,I/R+SCFAs组小鼠肾纤维化程度减轻,肾组织的CD68、TNF-α、ICAM-1表达降低,而且TLR4、MyD88、NF-κB p65、α-SMA蛋白表达水平亦降低(P均<0.05)。与I/R+SCFAs组相比,I/R+SCFAs+anti-CD25组病理损伤加重,Foxp3表达减少,而TNF-α、ICAM-1、RORγt表达升高(P均<0.05),TLR4、MyD88、NF-κB p65、α-SMA蛋白表达水平有所升高。结论SCFAs可能通过TLR4/MyD88/NF-κB通路抑制炎症因子产生,从而减轻肾脏炎症反应和肾纤维化。 展开更多
关键词 炎症 肾纤维化 短链脂肪酸 TOLL样受体4 调节性T细胞
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Development of dynamic shading control for daylight measures in green buildings towards overall energy efficiency of lighting and air-conditioning systems
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作者 jingting sun 《Low-carbon Materials and Green Construction》 2023年第1期273-287,共15页
The introduction of daylight can improve buildings’energy efficiency and bring benefit to occupant satisfaction.However,the introduction of daylight may accompany with excessive heat.Properly counterbalancing the ene... The introduction of daylight can improve buildings’energy efficiency and bring benefit to occupant satisfaction.However,the introduction of daylight may accompany with excessive heat.Properly counterbalancing the energy consumption of air conditioning and lighting systems owing to the entry of daylight is a critical control target of dynamic shading adjustment in cooling season.Most dynamic shading control strategies in use only consider one single system.Additionally,for advanced control mode like performance-based control,the predictive model usually only examines the instantaneous effect of energy performance to determine the shading adjustment state,unable to quantify the overall influence of shading adjustment state on building energy consumption.In order to address this issue,special consideration is given to calculating the cumulative contribution of heat gains to cooling load in this study.An overall energy-efficient shading control metric is proposed and used as basis to develop optimized dynamic shading control strategy.An application example demonstrates that the SGR-Optimal control strategy can further save energy by 21.8%~38.8%when compared to the Rule-based control strategy,thus allowing a better exploration of the energy efficiency potential of daylight measure. 展开更多
关键词 Energy simulation DAYLIGHT Shading control strategy Energy efficiency Green building
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Effect of typical meteorological year selection on integrated daylight modeling and building energy simulation
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作者 jingting sun Zhengrong Li +1 位作者 Cui Li Xiwen Feng 《Low-carbon Materials and Green Construction》 2023年第1期181-192,共12页
The complete description of outdoor luminous and thermal environment is the basis for daylight utilization design with simulation tools.Nevertheless,Typical Meteorological Year(TMY)and generation method specifically d... The complete description of outdoor luminous and thermal environment is the basis for daylight utilization design with simulation tools.Nevertheless,Typical Meteorological Year(TMY)and generation method specifically developed for the energy simulation of daylight-utilized buildings is still unavailable currently.Luminous environment parameters have not been taken into consideration in existing TMY generation methods.In this study,the feasibility of existing TMY generation process has been examined.A generic office model implementing sided window daylighting is established.Historical meteorological data of Hong Kong region from 1979 to 2007 have been collected and three existing weighting schemes are applied during the Typical Meteorological Month(TMM)selection procedures.Three TMY files for Hong Kong are generated and used to conduct integrated Climate-Based Daylight Modeling and building energy simulation.The result demonstrates that,on annual basis,the energy consumption results obtained from the generated TMY files are in good agreements with the long-term mean annual value.The maximum deviation of annual energy consumptions for the generated TMY files is only 1.8%.However,further analysis on monthly basis shows that all the three generated TMY files fail to fully represent the long-term monthly mean level.The maximum deviation of monthly energy consumptions for the generated TMY files can reach up to 11%.As the energy performance daylight utilization is subject to weather change,analysis on daily and monthly energy level is important,especially during design stage.The deficiency of existing TMM selection process and TMY generation method indicates the necessity to develop a corresponding typical weather data input with finer resolution for the energy simulation of daylight-related buildings. 展开更多
关键词 Typical meteorological year Building energy simulation Climate-based daylight modeling Daylight utilization
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Experimental study and assessment of thermal energy storage mortar with paraffin/recycled brick powder composite phase change materials
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作者 Luchen HAO Jianzhuang XIAO +1 位作者 Wanzhi CAO jingting sun 《Frontiers of Structural and Civil Engineering》 SCIE EI CSCD 2022年第10期1301-1314,共14页
Thermal energy storage recycled powder mortar(TESRM)was developed in this study by incorporating paraffin/recycled brick powder(paraffin/BP)composite phase change materials(PCM).Fourier transform infrared and thermogr... Thermal energy storage recycled powder mortar(TESRM)was developed in this study by incorporating paraffin/recycled brick powder(paraffin/BP)composite phase change materials(PCM).Fourier transform infrared and thermogravimetric analysis results showed that paraffin/BP composite PCM had good chemical and thermal stability.The onset melting temperature and latent heat of the composite PCM were 46.49°C and 30.1 J·g−1.The fresh mortar properties and hardened properties were also investigated in this study.Paraffin/BP composite PCM with replacement ratio of 0%,10%,20%,and 30%by weight of cement were studied.The results showed that the static and dynamic yield stresses of TESRM were 699.4%and 172.9%higher than those of normal mortar,respectively.The addition of paraffin/BP composite PCM had a positive impact on the mechanical properties of mortar at later ages,and could also reduce the dry shrinkage of mortar.The dry shrinkage of TESRM had a maximum reduction about 26.15%at 120 d.The thermal properties of TESRM were better than those of normal mortar.The thermal conductivity of TESRM was 36.3%less than that of normal mortar and the heating test results showed that TESRM had good thermal energy storage performance. 展开更多
关键词 recycled powder mortar recycled brick powder thermal energy storage PARAFFIN phase change material
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