The extraction of penicillin G by ionic liquid[Bmim]PF_6 has exhibited promising prospect.The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology.In this work,the stabi...The extraction of penicillin G by ionic liquid[Bmim]PF_6 has exhibited promising prospect.The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology.In this work,the stability of penicillin G in[Bmim]PF_6 was systematically investigated.The results showed the stability of penicillin G was significantly influenced by pH and temperature.It tended to be more stable when pH value increased from 1.5 to 4.0 and the temperature gradually decreased.The half-life(t_(1/2))of penicillin G in[Bmim]PF_6 was 17.7 h in the optimal technological condition(pH 2.0 and 10°C),which is enough for the requirement of extraction technology.The reaction of penicillin G in[Bmim]PF_6 followed the first order kinetics in the pH range 2.0–4.0.Three isomers of penicillin G were found through rearrangement at pH 2.0,and their structures were not affected by temperature.展开更多
基金Supported by the National Natural Science Foundation of China(21676272)Major Science and Technology Project of Water Pollution Control and Management in China(2017ZX07402003)the Key Research Program of the Chinese Academy of Sciences(ZDRW-ZS-2016-5-3)
文摘The extraction of penicillin G by ionic liquid[Bmim]PF_6 has exhibited promising prospect.The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology.In this work,the stability of penicillin G in[Bmim]PF_6 was systematically investigated.The results showed the stability of penicillin G was significantly influenced by pH and temperature.It tended to be more stable when pH value increased from 1.5 to 4.0 and the temperature gradually decreased.The half-life(t_(1/2))of penicillin G in[Bmim]PF_6 was 17.7 h in the optimal technological condition(pH 2.0 and 10°C),which is enough for the requirement of extraction technology.The reaction of penicillin G in[Bmim]PF_6 followed the first order kinetics in the pH range 2.0–4.0.Three isomers of penicillin G were found through rearrangement at pH 2.0,and their structures were not affected by temperature.
