Chemical constituents and pharmacological activities of Salvia miltiorrhiza

Salvia miltiorrhiza Bunge(S.miltiorrhiza),a perennial plant of the genus Salvia,is widely used in traditional folklore medicine.Previous chemical research on this plant contains diterpenoid quinones,phenolic acids,polysaccharides and other compounds.The pharmacological investigation of S.miltiorrhiza has shown that it has various pharmacological activities,such as cardiovascular system protection,anti-inflammatory,anti-oxidant,anti-tumor,liver protection,and neuroprotection activities.This research tends to give an overview of the main chemical constituents and pharmacological effects of S.miltiorrhiza,aiming to reveal its potential value and provide reference for its further development.

Research review on the main chemical constituents and pharmacological activities of Viburnum awabuki

Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and triterpenes.It has been reported that the extracts of V.awabuki have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting activities.The research progress on the chemical constituents of V.awabuki and pharmacological activities were summarized in this review.

Study of the mechanism underlying inhibitory effect of terpenoids from Daphne plants on liver cancer cells using a network pharmacology-based approach

Daphne plants,belonging to Thymelaeaceae,have been used as traditional Chinese medicine for thousands of years.Previous studies suggested that they exerted anti-tumor activities and reported a number of compounds with anti-tumor activities,isolated from the genus Daphne.However,the targets of these compounds have not been determined yet.In this study,network pharmacology was used to analyze 128 terpenoid compounds from the genus Daphne and 49 target proteins of liver cancer.The results suggested that the target with the most number of directed edges was 5yz0.The compound which docked with 5yz0 best is AR.DT.25(acutilobin D),and the compounds with total docking score greater than 10 were almost all Daphnane diterpenoids.The network pharmacology results predicted that the 5yz0 protein was one of the potential targets of the terpenoids from the genus Daphne and then suggested several new targets and compounds for further liver cancer research.

Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells

Camptotheca acuminate belongs to Nyssaceae family and has been used as traditional Chinese medicine for several years.A number of compounds with anti-tumor activities have been isolated from C.acuminate.However,the targets of some compounds have not been determined.In this study,network pharmacology methods were used to analyze 74 compounds from C.acuminate and 49 target proteins of liver cancer.The results showed that the target with the largest number of directed edges was Dihydroorotate Dehydrogenase(1d3g).The compound docked with 1d3g best was AL.23(19-O-methyangustoline).The results of this study provide further insight into the role of network pharmacology as an effective tool to illuminate the research on liver cancer.

Isolation and structural elucidation of the compounds from the fruits of Camptotheca acuminate

The fruit of Camptotheca acuminate is used as a traditional Chinese medicine.Eight compounds were isolated from the fruit of Camptotheca acuminate for the first time,including(+)-(S)-abscisic acid(1),blumenol A(2),(E)-3-hydroxymegastigm-7-en-9-one(3),(-)-(3R)-3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin(4),(-)-(3R)-8-methoxy-3-methyl-3,4-dihydro-1H-isochromen-1-one(5),neocnidilide(6),(3S)-butylphthalide(7)and senkyunolide I(8).Their structures were determined by comprehensive spectroscopic methods,including HRESIMS and 1D NMR.