Advances in Terrestrial Mammal Movement Ecology:An Overview

As a research field which is blooming quickly in recent years,movement ecology has been a worldwide concern and interest.However,movement ecology is so comprehensive and complicated that many articles only focus on few aspects or species.As tracking technologies and methods of movement data analysis develop,the abundance of movement data becomes available for demonstrating more scientific facts about animal movement.This article is aimed to summarize the advances of terrestrial mammal movement ecology in the past years to show its critical and potential research fields,as well as trying to ascertain direction of these advances.

Multi-stage Co-planning Model for Power Distribution System and Hydrogen Energy System Under Uncertainties

The increased deployment of electricity-based hydrogen production strengthens the coupling of power distribution system(PDS)and hydrogen energy system(HES).Considering that power to hydrogen(PtH)has great potential to facilitate the usage of renewable energy sources(RESs),the coordination of PDS and HES is important for planning purposes under high RES penetration.To this end,this paper proposes a multi-stage co-planning model for the PDS and HES.For the PDS,investment decisions on network assets and RES are optimized to supply the growing electric load and PtHs.For the HES,capacities of PtHs and hydrogen storages(HSs)are optimally determined to satisfy hydrogen load considering the hydrogen production,tube trailer transportation,and storage constraints.The overall planning problem is formulated as a multistage stochastic optimization model,in which the investment decisions are sequentially made as the uncertainties of electric and hydrogen load growth states are revealed gradually over periods.Case studies validate that the proposed co-planning model can reduce the total planning cost,promote RES consumption,and obtain more flexible decisions under long-term load growth uncertainties.

Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome.Here,we report that osteosarcoma Rab22a-NeoF1 fusion protein,together with its binding partner PYK2,is sorted into exosomes by HSP90 via its KFERQ-like motif(RVLFLN^(142)).The exosomal Rab22a-NeoF1 fusion protein facilitates the pulmonary pre-metastatic niche formation by recruiting bone marrow-derived macrophages.The exosomal PYK2 activates RhoA in its negative recipient osteosarcoma cells and induces signal transducer and activator of transcription 3 activation in its recipient macrophages to increase M2 phenotype.Consequently,lung metastases of its recipient osteosarcoma cells are promoted by this exosomal Rab22a-NeoF1 fusion protein,and this event can be targeted by disrupting its interaction with PYK2 using a designed internalizing RGD peptide.