Dual-directional regulation of spinal cord injury and the gut microbiota

There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut axis.The spinal cord is a vital important part of the central nervous system;however,the underlying association between spinal cord injury and gut interactions remains unknown.Recent studies suggest that patients with spinal cord injury frequently experience intestinal dysfunction and gut dysbiosis.Alterations in the gut microbiota can cause disruption in the intestinal barrier and trigger neurogenic inflammatory responses which may impede recovery after spinal cord injury.This review summarizes existing clinical and basic research on the relationship between the gut microbiota and spinal cord injury.Our research identified three key points.First,the gut microbiota in patients with spinal cord injury presents a key characteristic and gut dysbiosis may profoundly influence multiple organs and systems in patients with spinal cord injury.Second,following spinal cord injury,weakened intestinal peristalsis,prolonged intestinal transport time,and immune dysfunction of the intestine caused by abnormal autonomic nerve function,as well as frequent antibiotic treatment,may induce gut dysbiosis.Third,the gut microbiota and associated metabolites may act on central neurons and affect recovery after spinal cord injury;cytokines and the Toll-like receptor ligand pathways have been identified as crucial mechanisms in the communication between the gut microbiota and central nervous system.Fecal microbiota transplantation,probiotics,dietary interventions,and other therapies have been shown to serve a neuroprotective role in spinal cord injury by modulating the gut microbiota.Therapies targeting the gut microbiota or associated metabolites are a promising approach to promote functional recovery and improve the complications of spinal cord injury.

A Probabilistic Approach for Predicting Vessel Motion

Dear Editor,This letter addresses the challenge of forecasting the motion of real-world vessels over an extended period with a limited amount of available data.By employing stochastic differential equation(SDE)modeling,we integrate both deterministic and stochastic components of the available information.Subsequently,we establish a recursive prediction methodology based on Bayes’rule to update the model state when new measurements are received.Furthermore,we develop a stochastic model tailored specifically to vessel dynamics and introduce an approximation method to tackle computational complexities.Finally,we present an application example and conduct a comparative experiment to validate the effectiveness and superiority of the proposed method.

Pressure-Driven Energy Band Gap Narrowing of λ-N_(2)

Probing the energy band gap of solid nitrogen at high pressures is of importance for understanding pressuredriven changes in electronic structures and insulator-to-metal transitions under high pressure.The λ-N_(2) formed by cold compression is known to be the most stable one in all solid nitrogen phases observed so far.By optimizing the optical system,we successfully measured the high-pressure absorption spectra of λ-N_(2) covering the polymericnitrogen synthetic pressures(124 GPa-165 GPa).The measured optical band gap decreases with increasing pressure,from 2.23 eV at 124 GPa to 1.55 eV at 165 GPa,with a negative pressure coefficient of-18.4 meV/GPa,which is consistent with the result from our ab initio total-energy calculations(-22.6 meV/GPa).The extrapolative metallization pressure for theλ-N_(2) is around 288(18)GPa,which is close to the metallization pressure(280 GPa)for the η-N_(2) expected by previous absorption edge and direct electrical measurements.Our results provide a direct spectroscopic evidence for the pressure-driven band gap narrowing of solid nitrogen.

Anti-Stokes/Stokes temperature calibration and its application in laser-heating diamond anvil cells

Anti-Stokes/Stokes Raman peak intensity ratio was used to infer sample temperatures,but the influence factors of system correction factors were not clear.Non-contact in-situ anti-Stokes/Stokes temperature calibration was carried out for up to 1500 K based on six different samples under two excitation light sources(±50 K within 1000 K,±100 K above1000 K),and the system correction factorγwas systematically investigated.The results show that the correction factorγof anti-Stokes/Stokes thermometry is affected by the wavelength of the excitation light source,Raman mode peak position,temperature measurement region and other factors.The anti-Stokes/Stokes thermometry was applied to the laser-heating diamond anvil cell(LHDAC)experiment to investigate the anharmonic effect of h BN under high temperature and high pressure.It is concluded that the strong anharmonic effect caused by phonon scattering at low pressure gradually changes into the predominance of localized molecular lattice thermal expansion at high pressure.

Intensified haze formation and meteorological feedback by complex terrain in the North China Plain region

华北平原地区冬季雾霾污染频发,本研究结合地面观测,卫星反演和大气动力-化学耦合模拟发现,该地区复杂地形加剧了细颗粒物污染及其与大气边界层之间的相互作用.一方面,复杂地形导致污染在山麓平原积聚,加强迎风坡上升气流.在污染事件中,污染层易被抬升至1-2公里高度,高空较强的氧化能力利于二次气溶胶生成;另一方面,地形导致的污染层抬升和二次生成进一步加强气溶胶-边界层相互作用,削弱垂直扩散并加剧近地面大气污染.

Blow-Up for a Periodic Two-Component Camassa-Holm Equation with Generalized Weakly Dissipation

In this paper we study a periodic two-component Camassa-Holm equation with generalized weakly dissipation. The local well-posedness of Cauchy problem is investigated by utilizing Kato’s theorem. The blow-up criteria and the blow-up rate are established by applying monotonicity. Finally, the global existence results for solutions to the Cauchy problem of equation are proved by structuring functions.

自愈合离子凝胶的制备及传感测试

制备可自愈合离子凝胶及测试其应变和湿度感应,可用作本科新生的普通化学实验,经拓展内容后也适用于应用化学、高分子化学和材料科学与工程等相关专业本科生的综合实验。实验采用自由基聚合法将1-乙烯基-3-丁基咪唑四氟硼酸盐([VBIm][BF_(4)])制备成交联聚合物凝胶(PIL),1-丁基-3-甲基咪唑四氟硼酸盐([BMIm][BF_(4)],IL)充盈其中作为溶剂和添加剂。该PIL/IL离子凝胶中存在游离态的离子液体,具有良好的导电性,可对应变和湿度变化产生响应;同时,因具有较强离子键相互作用,该离子凝胶具有自愈合能力,可重复使用。

Cullin1对肺腺癌A549和H1395细胞生物学特性的影响

背景与目的Cullin1是Cullin家族中有代表性的一员,对细胞周期、转录和信号转导相关蛋白泛素化起重要作用,Cullin1与多种恶性肿瘤的发生发展有着密切的联系。本研究旨在探讨Cullin1对肺腺癌A549和H1395细胞生物功能的影响。方法实时荧光定量聚合酶链式反应(polymerase chain reaction,PCR)检测肺腺癌细胞(A549、H358、H1395、H1650)及人正常肺上皮细胞BEAS-2B中Cullin1 mRNA表达,采用siRNA技术干扰Cullin1 mRNA相对高表达的肺腺癌细胞;采用四甲基偶氮唑盐比色法(methyl thiazolyl tetrazolium assay,MTT)、流式细胞术及Transwell实验检测细胞增殖、细胞周期分布、细胞早期凋亡及侵袭和迁移能力;采用Western blot检测基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、组织基质金属酶抑制剂-1(tissue inhibitor of metalloproteinase-1,TIMP-1)、细胞周期蛋白D1(Cyclin D1)、细胞周期蛋白E2(Cyclin E2)、p21和p27蛋白的表达水平。结果与BEAS-2B细胞相比,肺腺癌细胞中Cullin1 mRNA均呈高表达,尤其在肺腺癌A549和H1395细胞中相对表达量较高(P<0.05);干扰Cullin1后肺腺癌细胞的增殖能力受到了抑制,G1期细胞增多,S期细胞数目减少,肺腺癌细胞早期凋亡率明显升高(P<0.05);肺腺癌细胞的侵袭及迁移能力下降(P<0.05);干扰Cullin1后MMP-9、MMP-2、Cyclin D1及Cyclin E2蛋白表达量减少(P<0.05),而TIMP-1、p21和p27蛋白表达量增多(P<0.05)。结论干扰Cullin1后可抑制肺腺癌A549和H1395细胞的增殖、侵袭和迁移,Cullin1在肺腺癌中发挥促癌作用。

Trends on physical understanding of bioink printability

Recently, 3D bioprinting is developed as an emerging approach, increasingly applied to materials for healthcare;while, the precise placement of cells and materials, and the shape fidelity of forming constructs is of great importance for successful application of 3D bioprinting. Research efforts have been made to develop new bioinks as "raw materials" with better biocompatibility and biofunctionality, but the printability of bioinks is largely ignored and still needs to be carefully examined to enable robotic bioprinting. This article aims to introduce a recent published review (Appl. Phys. Rev. 2018, 5, 041304) on the evaluation of bioink printability by Huang's research group from University of Florida. Huang et al. comprehensively reviewed the bioink printability based on the physical point of view during inkjet printing, laser printing, and microextrusion, and a series of self-consistent time scales and dimensi on less quantities were utilized to physically understand and evaluate bioink printability. This article would be helpful to know the trends on physical understanding of bioink printability.

Raman scattering from highly-stressed anvil diamond

The high-frequency edge of the first-order Raman mode of diamond reflects the stress state at the culet of anvil, and is often used for the pressure calibration in diamond anvil cell(DAC) experiments. Here we point out that the high-frequency edge of the diamond Raman phonon corresponds to the Brillouin zone(BZ) center Γ point as a function of pressure. The diamond Raman pressure gauge relies on the stability of crystal lattice of diamond under high stress. Upon the diamond anvil occurs failure under the uniaxial stress(197 GPa), the loss of intensity of the first-order Raman phonon and a stressdependent broad Raman band centered at 600 cm^(-1) are observed, which is associated with a strain-induced local mode corresponding to the BZ edge phonon of the L1 transverse acoustic phonon branch.

Effects of uniconazole rate on agronomic traits and physiological indexes of rapeseed blanket seedling

Mechanized transplanting of rapeseed(Brassica napus L.)blanket seedling is an innovative cultivation technology.Cultivating high quality blanket seedling to ensure high survival rate of seedling after transplanting is the key of the technology.The effects of different uniconazole rates of 0,0.5,1.0,1.5 and 2.0 mg/tray,spraying at one leaf and one heart stage,on selected agronomic traits,physiological indexes and survival rate of two rapeseed cultivars(‘Qinyou 100 and’Yangyou 90)were investigated in 2018 and 2019.Our results showed that the plant height decreased significantly with the increase of uniconazole rate.However,the collar diameter increased significantly with the increase of uniconazole rate up to 1.5 mg/tray,and the leaf area,dry weights of root and shoot increased with increased uniconazole rate up to 1.0 mg/tray.The root to shoot ratios,N concentrations of root and shoot with the uniconazole rates of 1.0 and 1.5 mg/tray were higher than those with other treatments.As uniconazole rate increasing,gibberellin(GA)and auxin(IAA)concentrations of root and shoot decreased,while abscisic acid(ABA)concentrations increased,and cytokinin(CTK)concentrations topped at uniconazole rate of 1.0 mg/tray and decreased thereafter.The seedling survival rates with 1.0 and 1.5 mg/tray were greatly higher than those in other treatments.Regression analysis suggested plant survival rate was positively related to CTK concentrations and negatively to GA concentrations of root and shoot.To achieve high survival rate after mechanized transplanting,our study revealed that the uniconazole applied at a rate of 1.0 mg/tray was recommended as the best,followed by 1.5 mg/tray.The findings would help to enhance qualities of rapeseed blanket seedling and to promote popularization of mechanized transplanting of rapeseed production.

High-pressure Raman study of osmium and rhenium up to 200 GPa and pressure dependent elastic shear modulus C_(44)

High-pressure Raman scattering from hexagonal close-packed(HCP) metals Os and Re have been extended up to 200 GPa, and the pressure-dependent shear modulus C_(44)has been deduced from the Raman-active mode E_(28), which is generated from the adjacent vibration of atoms in hexagonal planes, providing the valuable information about the elastic properties for HCP metals under high pressure. Combined with the available data of HCP metals from previous works,a further study indicates that the C_(44)/C_(44)ratio would be close to a constant value, 0.01, with increasing atomic number of metals. The results obtained from high-pressure Raman scattering will allow us to probe the elastic anisotropy of the HCP metals at very high pressure.

Identification of the sensitive area for targeted observation to improve vertical thermal structure prediction in summer in the Yellow Sea

The sensitive area of targeted observations for short-term(7 d)prediction of vertical thermal structure(VTS)in summer in the Yellow Sea was investigated.We applied the Conditional Nonlinear Optimal Perturbation(CNOP)method and an adjoint-free algorithm with the Regional Ocean Modeling System(ROMS).We used vertical integration of CNOP-type temperature errors to locate the sensitive areas,where reduction of initial errors is expected to yield the greatest improvement in VTS prediction for the selected verification area.The identified sensitive areas were northeast−southwest orientated northeast to the verification area,which were possibly related to the southwestward background currents.Then,we performed a series of sensitivity experiments to evaluate the effectiveness of the identified sensitive areas.Results show that initial errors in the identified sensitive areas had the greatest negative effect on VTS prediction in the verification area compared to errors in other areas(e.g.,the verification area and areas to its east and northeast).Moreover,removal of initial errors through deploying simulated observations in the identified sensitive areas led to more refined prediction than correction of initial conditions in the verification area itself.Our results suggest that implementation of targeted observation in the CNOP-based sensitive areas is an effective method to improve short-term prediction of VTS in summer in the Yellow Sea.

多巴胺介导针刺对创伤性脑损伤的唤醒作用及潜在机制

创伤性脑损伤(TBI)是由直接外力引起的脑损伤,其预后取决于损伤的程度和意识水平的变化。及时从昏迷中苏醒是TBI治疗中首先要解决的棘手问题。因此,需要开发安全有效的方法及时唤醒TBI昏迷。多巴胺(DA)及其神经系统受体参与觉醒的调节。多巴胺能神经元的数量和活性可影响细胞功能和神经炎症反应,对TBI后的觉醒过程也具有重要意义。目前常见的TBI觉醒疗法也可能与多巴胺能神经元的激活有关。针刺对TBI后的及时觉醒、意识水平恢复和功能康复具有有益作用。其机制可能与针刺对DA及其受体的靶向调控有关。在针刺急救疗法中,针刺12井穴以其操作简单、超早干预等优势,在TBI后的及时觉醒及一系列后续神经修复作用方面显示出巨大潜力。本文综述了DA在调节觉醒中的作用以及DA系统在针刺治疗TBI中的作用和可能机制,为TBI昏迷的及时觉醒提供了新的视角。

一种基于混沌与Bit位扰乱的彩色图像加密算法

本文提出了一种基于改进的Henon混沌映射与Bit位扰乱的彩色图像加密算法。首先,我们把明文图像的R、G、B三个通道合并成一个矩阵,同时还把其转换成二进制数;其次,把二进制数矩阵的行列进行扰乱,并把扰乱了的二进制数矩阵还原成十进制数矩阵;最后,把其分成三个像素个数相同的矩阵,再分别把三个矩阵进行按位“异或”运算,得到最终加密图像。实验结果和理论分析表明该算法具有密钥空间大,密钥敏感性高,能够有效地抵御统计分析和灰度值分析的攻击,对数字图像的加密具有良好的加密效果。

Evidence for a High-Pressure Isostructural Transition in Nitrogen

We observed an isostructural phase transition in the solid nitrogen λ-N_(2) at approximately 50 GPa accompanied by anomalies in lattice parameters,atomic volume and Raman vibron modes.The anomalies are ascribed to a slight reorientation of the nitrogen molecules,which does not seem to affect the monoclinic symmetry(space group P2_(1)/c).Our ab initio calculations further confirm the phenomena,and suggest an optimized structure for the λ-N_(2) phase.In addition,a new high-pressure amorphous phase of η′-N_(2) was also discovered by a detailed investigation of the pressure-temperature phase diagram of nitrogen with the aim of probing the phase stability of λ-N_(2).Our result may provide helpful information about the crystallographic nature of dissociation transitions in diatomic molecular crystals(H_(2),O_(2),N_(2),etc).

A New Digital Image Encryption Algorithm Based on Improved Logistic Mapping and Josephus Circle

Digital image encryption based on Joseph circle and Chaotic system has become a hot spot in the research of image encryption. An encryption algorithm based on improved Josephus loop and logistic mapping is proposed to scrambling blocks in this paper. At first, the original image is scrambled by using logistic mapping to obtain the encrypted image, and then the encrypted image is divided into many blocks. Finally, the position of the blocked image is scrambled by using the improved Josephus ring to get the encrypted image. According to the experiments, the information entropy of the encrypted image reaches 7.99 and the adjacent correlations in three directions are within ±0.1. The experimental results show that the proposed algorithm has advantages of large key space, high key sensitivity and can effectively resist the attacks of statistical analysis and gray value analysis. It has good encryption effect on digital image encryption.

Effect of N-fertilizer Application on Yield,Grain Quality and N-fertilizer Use Efficiency of the Rapeseed Cultivars with Normal and High Oil Content

In this study,seed yield,quality and N-fertilizer use efficiency in rape(Brassica napus L.) were researched in normal oil content cultivar(Yangyou 6) and two high oil content cultivars(Zhongshuang 11 and Zheyou 50). Results showed that the average oil content of all treatments in Yangyou 6,Zhongshuang 11 and Zheyou 50 was 42. 87%,47. 37% and 48. 28%,respectively. The average protein content of all treatments in Yangyou 6,Zhongshuang 11 and Zheyou 50 was 24. 15%,22. 71% and 21. 84%,respectively. The increased ratio of total nitrogen accumulation amount in Yangyou 6 was higher than that in Zhongshuang 11 and Zheyou 50. Among three cultivars,the total protein accumulation amount in Yangyou 6 was highest,and the total oil accumulation amount was highest in Zheyou 50. With increasing nitrogen fertilization,the value of different parameters of N-fertilizer use efficiency decreased. The average N use efficiency in Yangyou 6 was 68. 70%,which was higher than that in Zhongshuang 11 and Zheyou 50(65. 06% and 60. 30%,respectively). The average N-fertilizer agronomic use efficiency in Yangyou 6 was also highest among three cultivars,which was 8. 97 kg seed / kg N. On the contrary,the average N-fertilizer physiological use efficiency in Zhongshuang 11 and Zheyou 50 was 13. 03 kg seed / kg N and 13. 84 kg seed / kg N,respectively,which was higher than that in Yangyou 6(12. 91 kg seed / kg N). Differences in partial factor productivity of N-fertilizer were slight among three cultivars.

Corporate Social Responsibility and Corporate Financial Performance -Empirical Research of Chinese Culture, Sports and Entertainment industry

Since 2006, the public corporations in China are required to include its social responsibilities in its annual report by company law. Corporations’ business activities should not only focus on maximizing its economic profit but also serve the society. With the awareness of the importance of social responsibility, there are an increasing number of public corporations in China to undertake more charitable activities or employee training activities. There have been a lot of academic researches investigating the relationship between corporate social responsibilities and corporate financial performance. However, the results are inconsistent and vary according to different industries. This study chose Chinese culture, sports and entertainment industry as a sample to test the relationship between CSR and corporate financial performance. Four financial ratios were used to test whether the caproate’s reasonability to government, employee, investors and society has significant impact on its financial performance. The empirical results show that apart from the responsibility to employees which is negatively influence the corporate financial performance the other three factors are found not significantly influence corporate financial performance.

Tunning the Band Gap of 1T’-WTe2 by Uniaxial Strain

The QSH edge channels can be used to connect dissipationless nanoelectronic devices, when the topological edge states and the bulk states have the perfectly spaced. But the monolayer 1T’-WTe2 bulk state is metallic nature, with edge channel lengths around 100 nm, which hinders its further study. By simulating the different terminational edge states, using the GGA-1/2 method to calculate, we found a stable terminational edge state. And under strain engineering, fixed the a-axis, the band gap gradually increases with the b-axis tensile. When the tensile to 2.9%, the band gap increases to 245 meV. It greatly improves the application of 1T’-WTe2. During the phase transition of the material from half-metal to insulator, the topology of edge states remains unchanged, showing strong robustness. Thus introducing strain can make 1T’-WTe2 a suitable material for fundamental research or topological electronic devices.