Association of Lifestyle Factors and Sperm Motility in Adults from an Ethnic Minority Region of Southwest China

Objectives: To understand sperm motility in adults and its association with lifestyle in an ethnic minority area in Southwest China. Methods: A hospital-based cross-sectional study to assess sperm motility in male adults was conducted at the Reproductive Health Center from January 2018 to May 2019. The data was collected with a questionnaire and semen quality was analyzed with Computer-Aided Sperm Analysis system (CASA). Analysis of covariance (ANCOVA) was used to measure the relationship between lifestyle factors and sperm motility. Results: A total of 349 people were recruited. Dietary celery intake was significantly related to the increase of sperm progressive motility and total motility (β = 7.00, 95% CI: 1.59, 12.42 and β = 7.26, 95% CI: 1.45, 13.07, respectively). Cola consumption was associated with increased sperm progressive motility (β = 9.71, 95% CI: 1.46, 17.96). Frequent use of plastic bags for meat food storage (β = -5.56, 95% CI: -10.61, -0.51), industry work (β = -5.64, 95% CI: -11.21, -0.07), organic disease (β = -6.14, 95% CI: -11.00, -1.28) and sedentary lifestyle (β = -5.92, 95% CI: -10.66, -1.17 for 3-5 h/d and β = -6.04, 95% CI: -11.60, -0.47 for ≥5 h/d, respectively) were related with the decreased sperm progressive motility. Meanwhile, using plastic bags for meat food storage (β = -6.37, 95% CI: -11.79, -0.95), industry work (β = -7.96, 95% CI: -13.94, -1.98) and sedentary lifestyle (β = -5.51, 95% CI: -10.60, -0.42 for 3-5 h/d and β = -6.03, 95% CI: -12.01, -0.06 for ≥5 h/d, respectively) were also risk factors for total motility. Conclusions: Some modifiable lifestyle factors such as job title, cola consumption, dietary celery intake, plastic bags for meat food storage, and sedentary hours were linked to male sperm motility, indicating that changing these lifestyles may improve it.

基于分子动力学模拟的木材细胞壁与水分相互作用研究进展

木材是一种典型的天然高分子材料,在分子尺度上解读水分对木材微纳结构的影响,是木材中水分研究的重难点。文中概述了分子动力学模拟的一般过程,重点介绍了近年来分子动力学模拟在木材-水分的研究领域中,对细胞壁化学组分纤维素、半纤维素、木质素与水分相互作用以及细胞壁各组分之间的界面与水分相互作用等方面的最新研究进展,最后提出了相关的现存问题,并就未来的发展方向进行展望,以期为深入揭示木材与水分的相互作用提供参考。

Optimal Operation Strategy of Electricity-Hydrogen Regional Energy System under Carbon-Electricity Market Trading

Given the“double carbon”objective and the drive toward low-carbon power,investigating the integration and interaction within the carbon-electricity market can enhance renewable energy utilization and facilitate energy conservation and emission reduction endeavors.However,further research is necessary to explore operational optimization methods for establishing a regional energy system using Power-to-Hydrogen(P2H)technology,focusing on participating in combined carbon-electricity market transactions.This study introduces an innovative Electro-Hydrogen Regional Energy System(EHRES)in this context.This system integrates renewable energy sources,a P2H system,cogeneration units,and energy storage devices.The core purpose of this integration is to optimize renewable energy utilization and minimize carbon emissions.This study aims to formulate an optimal operational strategy for EHRES,enabling its dynamic engagement in carbon-electricity market transactions.The initial phase entails establishing the technological framework of the electricity-hydrogen coupling system integrated with P2H.Subsequently,an analysis is conducted to examine the operational mode of EHRES as it participates in carbon-electricity market transactions.Additionally,the system scheduling model includes a stepped carbon trading price mechanism,considering the combined heat and power generation characteristics of the Hydrogen Fuel Cell(HFC).This facilitates the establishment of an optimal operational model for EHRES,aiming to minimize the overall operating cost.The simulation example illustrates that the coordinated operation of EHRES in carbon-electricity market transactions holds the potential to improve renewable energy utilization and reduce the overall system cost.This result carries significant implications for attaining advantages in both low-carbon and economic aspects.

Optimization of a precise integration method for seismic modeling based on graphic processing unit

General purpose graphic processing unit （GPU） calculation technology is gradually widely used in various fields. Its mode of single instruction, multiple threads is capable of seismic numerical simulation which has a huge quantity of data and calculation steps. In this study, we introduce a GPU-based parallel calculation method of a precise integration method （PIM） for seismic forward modeling. Compared with CPU single-core calculation, GPU parallel calculating perfectly keeps the features of PIM, which has small bandwidth, high accuracy and capability of modeling complex substructures, and GPU calculation brings high computational efficiency, which means that high-performing GPU parallel calculation can make seismic forward modeling closer to real seismic records.

Effects of enteral nutrition intervention on immune and nutritional indexes of patients with gastric malignant cancer during postoperative chemotherapy

Objective The aim of this study was to investigate changes in nutritional status and related indexes in patients with Nutritional Risk Score(NRS)≥3 gastric cancer after nutritional support treatment.Methods A total of 50 patients with gastric cancer were divided into two groups according to the different nutritional support treatment they received during postoperative chemotherapy:immune-enhanced enteral nutrition group(n=25)and conventional enteral nutrition group(n=25).Changes in patient’body mass index(BMI),hemoglobin(HB),serum total protein(TP),serum albumin(ALB),and immune indexes(CD3+,CD4+/CD8+,CD3+/CD8+)were monitored before and after chemotherapy.At the same time,the incidence and classification of gastrointestinal adverse reactions after chemotherapy were assessed.Results Compared with the conventional enteral nutrition group,the nutritional and immune indexes in the immune-enhanced enteral nutrition group were significantly improved.After chemotherapy,the incidence of adverse reactions in the digestive tract was relatively lower and the grade was reduced.Conclusion Immune-enhanced enteral nutrition support can significantly improve the nutritional status of patients,improve immune function,increase the susceptibility of cancer patients to chemotherapy,reduce toxicity and adverse effects,and improve the quality of life of tumor patients compared with conventional enteral nutrition support.

Application of Bioinformatics in Microbial Ecology

The rapid development of high-throughput sequencing technology has greatly promoted the study on microbial diversity. Various bioinformatics softwares were developed and used to analyze the large number of gene information generated from the utilization of this technology. Application of bioinformatics in microbial ecology and the corresponding softwares and databases adopted in α, β-diversity study were summarized in the paper.

Gap-free genome assembly and comparative analysis reveal the evolution and anthocyanin accumulation mechanism of Rhodomyrtus tomentosa

Rhodomyrtus tomentosa is an important f leshy-fruited tree and a well-known medicinal plant of the Myrtaceae family that is widely cultivated in tropical and subtropical areas of the world.However,studies on the evolution and genomic breeding of R.tomentosa were hindered by the lack of a reference genome.Here,we presented a chromosome-level gap-free T2T genome assembly of R.tomentosa using PacBio and ONT long read sequencing.We assembled the genome with size of 470.35 Mb and contig N50 of∼43.80 Mb with 11 pseudochromosomes.A total of 33382 genes and 239.31 Mb of repetitive sequences were annotated in this genome.Phylogenetic analysis elucidated the independent evolution of R.tomentosa starting from 14.37MYA and shared a recent WGD event with other Myrtaceae species.We identified four major compounds of anthocyanins and their synthetic pathways in R.tomentosa.Comparative genomic and gene expression analysis suggested the coloring and high anthocyanin accumulation in R.tomentosa tends to be determined by the activation of anthocyanin synthesis pathway.The positive selection and up-regulation of MYB transcription factors were the implicit factors in this process.The copy number increase of downstream anthocyanin transport-related OMT and GST gene were also detected in R.tomentosa.Expression analysis and pathway identification enriched the importance of starch degradation,response to stimuli,effect of hormones,and cell wall metabolism during the f leshy fruit development in Myrtaceae.Our genome assembly provided a foundation for investigating the origins and differentiation of Myrtaceae species and accelerated the genetic improvement of R.tomentosa.

THE LAW OF THE ITERATED LOGARITHM FOR SPATIAL AVERAGES OF THE STOCHASTIC HEAT EQUATION

Let u(t,x)be the solution to the one-dimensional nonlinear stochastic heat equation driven by space-time white noise with u(0,x)=1 for all x∈R.In this paper,we prove the law of the iterated logarithm(LIL for short)and the functional LIL for a linear additive functional of the form∫[0,R]u(t,x)dx and the nonlinear additive functionals of the form∫[0,R]g(u(t,x))dx,where g:R→R is nonrandom and Lipschitz continuous,as R→∞for fixed t>0,using the localization argument.

Cobalt-Catalyzed Switchable[4+1]and[4+1+1]Spirocyclization of Aromatic Amides with 2-Diazo-1H-indene-1,3(2H)-dione:Access to Spiro Indene-2,1'-isoindolinones and Spiro Isochroman-3,1'-isoindolinones

Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-dione.When the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]spirocyclization.When the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen source.In general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility.

儿童教育的旨趣:呵护生命自由生长

儿童教育的旨趣在于呵护生命的自由生长,包括"活在爱中"并促进爱的生长、创造力的绵延、良好人格的养成等方面。然而,"原罪"的膨胀和为了抑制"原罪"而导致的强制会对儿童的自由生长产生消极影响。为此,需要通过构建审美意境来消弭"原罪",通过建立情感联结来引导和陪伴儿童发展,并在此过程中重视儿童的自主探索,保护和激发其好奇心,营造理解的氛围,包容儿童的个体差异,鼓励儿童富有个性地自由生长。

Colloidal synthesis and phase transformation of all-inorganic bismuth halide perovskite nanoplates

Lead-free bismuth-based halide perovskites and their analogues have attracted research interest for their high stability and optoelectronic properties.However,the morphology-controlled synthesis of bismuth-based perovskite nanocrystals has been rarely demonstrated.Herein,we report the colloidal synthesis of zero-dimensional(0D)Cs3BiCl6 nanosheets(NSs),Cs3Bi2Cl9 NSs/nanoplates(NPs)and Cs4MnBi2Cl12 NPs through a hot-injection method.We demonstrate that the Cs3BiCl6 NSs,as an initial product of Cs3Bi2Cl9 and Cs4MnBi2Cl12 NPs,can transform into Cs3Bi2Cl9 NSs or Cs4MnBi2Cl12 NPs via Cl-induced metal ion insertion reactions under the templating effect of Cs3BiCl6.This growth mechanism is also applicable for the synthesis of Cs4CdBi2Cl12 nanoplates.Furthermore,the alloying of Cd2+into Cs4MnBi2Cl12 lattice could weaken the strong coupling effect between Mn and Mn,which leads to a prolonged photoluminescence lifetime and an enhanced photoluminescence quantum yield(PLQY).As a proof of concept,the alloyed Cs4MnxCd1–xBi2Cl12 NPs are used as a scintillator,which show a lowest detection limit of 134.5 nGy/s.The X-ray imaging results display a high spatial resolution of over 20 line pairs per millimeter(lp/mm).These results provide new insights in the synthesis of anisotropic bismuth-based perovskite nanocrystals and their applications in radiation detection.

Bio-assembled MgO-coated tea waste biochar efficiently decontaminates phosphate from water and kitchen waste fermentation liquid

Crystal morphology of metal oxides in engineered metal-biochar composites governs the removal of phosphorus(P)from aqueous solutions.Up to our best knowledge,preparation of bio-assembled MgO-coated biochar and its application for the removal of P from solutions and kitchen waste fermentation liquids have not yet been studied.Therefore,in this study,a needle-like MgO particle coated tea waste biochar composite(MTC)was prepared through a novel biological assembly and template elimination process.The produced MTC was used as an adsorbent for removing P from a synthetic solution and real kitchen waste fermentation liquid.The maximum P sorption capacities of the MTC,deduced from the Langmuir model,were 58.80 mg g^(−1) from the solution at pH 7 and 192.8 mg g^(−1) from the fermentation liquid at pH 9.The increase of ionic strength(0-0.1 mol L^(−1) NaNO_(3))reduced P removal efficiency from 98.53%to 93.01%in the synthetic solution but had no significant impact on P removal from the fermentation liquid.Precipitation of MgHPO4 and Mg(H_(2)PO_(4))_(2)(76.5%),ligand exchange(18.0%),and electrostatic attraction(5.5%)were the potential mechanisms for P sorption from the synthetic solution,while struvite formation(57.6%)and ligand exchange(42.2%)governed the sorption of P from the kitchen waste fermentation liquid.Compared to previously reported MgO-biochar composites,MTC had a lower P sorption capacity in phosphate solution but a higher P sorption capacity in fermentation liquid.Therefore,the studied MTC could be used as an effective candidate for the removal of P from aqueous environments,and especially from the fermentation liquids.In the future,it will be necessary to systematically compare the performance of metal-biochar composites with different metal oxide crystal morphology for P removal from different types of wastewater.

A bibliometric review of driver information processing and application studies

With the continuous development of information technology,the information environment while driving is constantly being enriched,and driver information processing and application are also dynamically evolving.Analysing information processing and application can better provide information services and is particularly important for traffic safety.Based on VOSviewer bibliometric software,this paper explores the research hotspots and future development trends of the driver information processing and application fields using the Web of Science(WoS)core collection as the data source.The results show that the field has a long history and has grown steadily in recent years.The United States,China and Germany are the top three countries in terms of the number of published articles.“Situational awareness and visual load”,“route selection under variable information signs”,“en-route information and behaviour”and“new information technology attitudes”are important knowledge bases for driver information processing and application.En-route information sources,human-computer interaction,and autonomous vehicle information are the research trends of the driver information processing and application field.The results of this research can help people comprehensively and systematically understand the current situation of driver information processing and application research,provide directions for future driver information processing and application research,and promote the engineering application of such research.

Temperature-switching logic in MoS2 single transistors

Due to their unique characteristics,two-dimensional(2D)materials have drawn great attention as promising candidates for the next generation of integrated circuits,which generate a calculation unit with a new working mechanism,called a logic transistor.To figure out the application prospects of logic transistors,exploring the temperature dependence of logic characteristics is important.In this work,we explore the temperature effect on the electrical characteristic of a logic transistor,finding that changes in temperature cause transformation in the calculation:logical output converts from‘AND’at 10 K to‘OR’at 250 K.The transformation phenomenon of temperature regulation in logical output is caused by energy band which decreases with increasing temperature.In the experiment,the indirect band gap of MoS2 shows an obvious decrease from 1.581 eV to 1.535 eV as the temperature increases from 10 K to 250 K.The change of threshold voltage with temperature is consistent with the energy band,which confirms the theoretical analysis.Therefore,as a promising material for future integrated circuits,the demonstrated characteristic of 2D transistors suggests possible application for future functional devices.

Common Problems and Maintenance Management of Highway Bridges

China is currently undergoing rapid urbanization,and highway and bridge construction projects are increasing in both quantity and scope.They are one of the important infrastructures in urban construction.The requirements for the construction of bridge engineering projects are relatively high,but due to the influence of various factors,problems are bound to occur,which affects the aesthetics and functionality of the bridge.Therefore,it is necessary to strengthen the analysis of common problems of highway bridges,understand the causes,and put forward corresponding countermeasures.

Tunable magneto-Seebeck effect in Co_(2)FeSi/MgO/Co_(2)FeSi heterostructure via optimized interfacial engineering

Enhancing the tunneling magneto-Seebeck(TMS) ratio and uncovering its underlying mechanism are greatly demanded in spin caloritronics.The magnitude and sign of the TMS effect depend on the type of atom and the stacking order of atoms at the interfaces.Herein,we demonstrate that TMS ratios can be effectively manipulated by altering heterogonous or homogeneous interface through decoration on the CoFeSi(001) surface inserted on the MgO insulating layers.The maximum TMS ratio of pure Co_(2)/O termination is 4565% at 800 K.Notably,the TMS ratio of the FeSi/O termination has two peak values,of which the maximum could reach up to-3290% at 650 K.By comparing two different atom arrangements at the interface,we reveal that the sign and symbol of the TMS ratio can be controlled by the temperature and different atomic configurations at the Co_(2)FeSi/MgO interface.Furthermore,the spin-Seebeck coefficient up to ~150 μV/K is also possible when we select suitable terminations and temperatures.These findings will provide useful insights into how to control the sign and symbol of the TMS ratio and accordingly stimulate the development field of magneto-thermoelectric power and spin caloritronic devices based on the magneto-Seebeck effect in Heusler-based metallic multilayers.

Porous silicon carbide coated with tantalum as potential material for bone implants

Porous silicon carbide(SiC)has a specific biomorphous microstructure similar to the trabecular microstructure of human bone.Compared with that of bioactive ceramics,such as calcium phosphate,SiC does not induce spontaneous interface bonding to living bone.In this study,bioactive tantalum(Ta)metal deposited on porous SiC scaffolds by chemical vapour deposition was investigated to accelerate osseointegration and improve the bonding to bones.Scanning electron microscopy indicated that the Ta coating evenly covered the entire scaffold structure.Energy-dispersive spectroscopy and X-ray diffraction analysis showed that the coating consisted of Ta phases.The bonding strength between the Ta coating and the SiC substrate is 88.4MPa.The yield strength of porous SiC with a Ta coating(pTa)was 45.862.9MPa,the compressive strength was 61.463.2MPa and the elasticmodulus was4.8GPa.When MG-63 human osteoblasts were co-cultured with pTa,osteoblasts showed good adhesion and spreading on the surface of the pTa and its porous structure,which showed that it has excellent bioactivity and cyto-compatibility.To further study the osseointegration properties of pTa.PTa and porous titanium(pTi)were implanted into the femoral neck of goats for 12weeks,respectively.The Van-Gieson staining of histological sections results that the pTa group had better osseointegration than the pTi group.These results indicate that coating bioactive Ta metal on porous SiC scaffolds could be a potential material for bone substitutes.

Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques

Dear Editor,The unprecedented COVID-19 pandemic caused by SARS-CoV-2 remains ongoing,but there is a lack of fully effective treatments.Convalescent plasma-derived hyperimmune globulins have been a safe and effective treatment but restricted by the difficulties in obtaining sufficient plasma with high antibody titers from a large number of recovered patients.Heterologous antibodies,particularly equine antibodies,have been widely used for decades as the therapeutics against some viral infections or as antivenoms.1 Equine antibodies could be rapidly developed and manufactured into therapeutic antibodies in large quantities under WHO standardized guidelines.Here we explored the development of equine antibody-derived F(ab′)2 as an option to treat COVID-19 by targeting the receptor-binding domain(RBD)of the viral spike protein that is essential for the viral entry into the host cells.2 We observed excellent neutralization titers of the F(ab′)2 in vitro and high potency against SARS-CoV-2 infection in the nonhuman primate rhesus macaques.

Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish

Cyclin-dependent kinase 1 (CDK1) plays an essential role in cell cycle regulation.However,as mouse Cdk1embryos die early,the role of CDK1 in regulating the cell cycle and embryo development remains unclear.Here,we showed that zebrafish cdk1^(-/-)embryos exhibit severe microphthalmia accompanied by multiple defects in S phase entry,M phase progression,and cell differentiation but not in interkinetic nuclear migration.We identified Top2a as a potential downstream target and cyclin A2 and cyclin B1 as partners of Cdk1 in cell cycle regulation via an in silico analysis.While depletion of either cyclin A2 or Top2a led to the decreased S phase entry in zebrafish retinal cells,the depletion of cyclin B1 led to M phase arrest.Moreover,phosphorylation of Top2a at serine 1213 (S1213) was nearly abolished in both cdk1 and ccna2mutants,but not in ccnb1 mutants.Furthermore,overexpression of TOP2A^(S1213D),the phosphomimetic form of human TOP2A,rescued S phase entry and alleviated the microphthalmia defects in both cdk1^(-/-)and ccna2^(-/-)embryos.Taken together,our data suggest that Cdk1 interacts with cyclin A2 to regulate S phase entry partially through Top2a phosphorylation and interacts with cyclin B1 to regulate M phase progression.