A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson＇s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demon...A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson＇s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demonstrating that the LRRK2 gene polymorphism S1647T variant is a risk factor for Parkinson＇s disease in a Chinese Han population. However, the R1398H variant did not influence the risk for Parkinson＇s disease. In addition, there was no difference in clinical symptoms of Parkinson＇s disease patients with various genotypes. Results showed that the LRRK2 S1647T variant was associated with an increased risk for developing early-onset Parkinson＇s disease in a Chinese Hart population. In addition, there was no correlation between LRRK2 S1647T, R1398H variants and G2385R, R1628P variants in Parkinson＇s disease patients.展开更多
Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentrat...Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentration range for mitomycin C, cotton pads soaked with mitomycin C at different concentrations （0.1, 0.3, 0.5, and 0.7 mg/mL） were immediately applied for 5 minutes to the operation area of rats that had undergone laminectomy at L1. Rat sciatic nerves, instead of dorsal nerves, were used in this study. The results showed that mitomycin C at 0.1-0.5 mg/mL did not damage the structure and function of the sciatic nerve, while at 0.7 mg/mL, mitomycin C signiifcantly reduced the thickness of the sciatic nerve myelin sheath compared with lower concen-trations, though no functional change was found. These experimental ifndings indicate that the local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy, but that mitomycin C at high concentrations （＆gt;0.7 mg/mL） has potential safety risks to peripheral nerve structures.展开更多
1 Introduction and main contributions Various power-aware solutions have been proposed to address the alarming energy waste and consequent serious environmental issues since Gupta and Singh initiated the seminal study...1 Introduction and main contributions Various power-aware solutions have been proposed to address the alarming energy waste and consequent serious environmental issues since Gupta and Singh initiated the seminal study on green networking problem in 2003.Most of the researches concentrated their efforts on power-aware networking under the non-bundled link scenarios by leveraging the dynamic power management based Low Power Idle(LPI)policy which was defined and standardized in the IEEE 802.3az standard.However,in modern backbone networks,pairs of routers are typically connected,for each traffic direction,by multiple physical links that form one logical bundled link,which is the link aggregation technique defined and standardized in IEEE 802.1AX.展开更多
Phenotypic plasticity is the ability of a given genotype to produce multiple phenotypes in response to changing environmental conditions.Understanding the genetic basis of phenotypic plasticity and establishing a pred...Phenotypic plasticity is the ability of a given genotype to produce multiple phenotypes in response to changing environmental conditions.Understanding the genetic basis of phenotypic plasticity and establishing a predictive model is highly relevant to future agriculture under a changing climate.Here we report findings on the genetic basis of phenotypic plasticity for 23 complex traits using a diverse maize population planted at five sites with distinct environmental conditions.We found that latituderelated environmental factors were the main drivers of across-site variation in flowering time traits but not in plant architecture or yield traits.For the 23 traits,we detected 109 quantitative trait loci(QTLs),29 for mean values,66 for plasticity,and 14 for both parameters,and 80%of the QTLs interacted with latitude.The effects of several QTLs changed in magnitude or sign,driving variation in phenotypic plasticity.We experimentally validated one plastic gene,ZmTPS14.1,whose effect was likely mediated by the compensation effect of ZmSPL6 from a downstream pathway.By integrating genetic diversity,environmental variation,and their interaction into a joint model,we could provide site-specific predictions with increased accuracy by as much as 9.9%,2.2%,and 2.6%for days to tassel,plant height,and ear weight,respectively.This study revealed a complex genetic architecture involving multiple alleles,pleiotropy,and genotype-byenvironment interaction that underlies variation in the mean and plasticity of maize complex traits.It provides novel insights into the dynamic genetic architecture of agronomic traits in response to changing environments,paving a practical way toward precision agriculture.展开更多
基金Supported by the National Natural Science Foundation of China, No. 30870846
文摘A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson＇s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demonstrating that the LRRK2 gene polymorphism S1647T variant is a risk factor for Parkinson＇s disease in a Chinese Han population. However, the R1398H variant did not influence the risk for Parkinson＇s disease. In addition, there was no difference in clinical symptoms of Parkinson＇s disease patients with various genotypes. Results showed that the LRRK2 S1647T variant was associated with an increased risk for developing early-onset Parkinson＇s disease in a Chinese Hart population. In addition, there was no correlation between LRRK2 S1647T, R1398H variants and G2385R, R1628P variants in Parkinson＇s disease patients.
基金supported by the National Natural Science Foundation of China,No.81171694,81201374,81371968,81371969a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Nature Science Foundation of Jiangsu Province No.BK2012718,BK2011844
文摘Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentration range for mitomycin C, cotton pads soaked with mitomycin C at different concentrations （0.1, 0.3, 0.5, and 0.7 mg/mL） were immediately applied for 5 minutes to the operation area of rats that had undergone laminectomy at L1. Rat sciatic nerves, instead of dorsal nerves, were used in this study. The results showed that mitomycin C at 0.1-0.5 mg/mL did not damage the structure and function of the sciatic nerve, while at 0.7 mg/mL, mitomycin C signiifcantly reduced the thickness of the sciatic nerve myelin sheath compared with lower concen-trations, though no functional change was found. These experimental ifndings indicate that the local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy, but that mitomycin C at high concentrations （＆gt;0.7 mg/mL） has potential safety risks to peripheral nerve structures.
基金supported by the 2021 High-Level Talents Scientific Research Start-Up Funding Project of West Anhui University(No.WGKQ2021054)the Natural Science Research Key Project of Anhui Educational Committee(No.2022AH051667)the National Natural Science Foundation of China(Grant Nos.62032013 and 92267206).
文摘1 Introduction and main contributions Various power-aware solutions have been proposed to address the alarming energy waste and consequent serious environmental issues since Gupta and Singh initiated the seminal study on green networking problem in 2003.Most of the researches concentrated their efforts on power-aware networking under the non-bundled link scenarios by leveraging the dynamic power management based Low Power Idle(LPI)policy which was defined and standardized in the IEEE 802.3az standard.However,in modern backbone networks,pairs of routers are typically connected,for each traffic direction,by multiple physical links that form one logical bundled link,which is the link aggregation technique defined and standardized in IEEE 802.1AX.
基金funded by the Natural Science Foundation of China(31961133002,31901553,and 31771879)the National Key Research and Development Program of China(2020YFE0202300)+3 种基金the Science and Technology Major Program of Hubei Province(2021ABA011)the Swedish Research Council for Environment,Agricultural Sciences,and Spatial Planning(2019-01600)the Key Science and Technology Project of the China National Tobacco Corporation(110202101040 JY-17)the Jilin Scientific and Technological Development Program(20190201290JC).
文摘Phenotypic plasticity is the ability of a given genotype to produce multiple phenotypes in response to changing environmental conditions.Understanding the genetic basis of phenotypic plasticity and establishing a predictive model is highly relevant to future agriculture under a changing climate.Here we report findings on the genetic basis of phenotypic plasticity for 23 complex traits using a diverse maize population planted at five sites with distinct environmental conditions.We found that latituderelated environmental factors were the main drivers of across-site variation in flowering time traits but not in plant architecture or yield traits.For the 23 traits,we detected 109 quantitative trait loci(QTLs),29 for mean values,66 for plasticity,and 14 for both parameters,and 80%of the QTLs interacted with latitude.The effects of several QTLs changed in magnitude or sign,driving variation in phenotypic plasticity.We experimentally validated one plastic gene,ZmTPS14.1,whose effect was likely mediated by the compensation effect of ZmSPL6 from a downstream pathway.By integrating genetic diversity,environmental variation,and their interaction into a joint model,we could provide site-specific predictions with increased accuracy by as much as 9.9%,2.2%,and 2.6%for days to tassel,plant height,and ear weight,respectively.This study revealed a complex genetic architecture involving multiple alleles,pleiotropy,and genotype-byenvironment interaction that underlies variation in the mean and plasticity of maize complex traits.It provides novel insights into the dynamic genetic architecture of agronomic traits in response to changing environments,paving a practical way toward precision agriculture.
