Dear Editor, Many forms of sight-threatening diseases, including retinitis pigmentosa (RP) and age-related macular degeneration (AMD), are caused by the dysfunction, degeneration and loss of the retinal pigment epithe...Dear Editor, Many forms of sight-threatening diseases, including retinitis pigmentosa (RP) and age-related macular degeneration (AMD), are caused by the dysfunction, degeneration and loss of the retinal pigment epithelium (RPE)(Strauss, 2005). RPE cell transplantation may potentially recover or halt disease progression, in which human embryonic stem cells (hESCs) could serve as an unlimited donor source for RPE differentiation, and a few clinical trials have shown the safety and effective of transplantation of hESCs-derived RPE (hESC-RPE) for AMD patients (Schwartz et al., 2012;Schwartz etal., 2015;Song etal., 2015;da Cruz et al., 2018;Kashani et al., 2018;Liu et al., 2018).展开更多
For any given coprime integers p and q greater than 1, in 1959, B proved that all sufficiently large integers can be expressed as a sum of pairwise terms of the form p^aq^b. As Davenport observed, Birch＇s proof can b...For any given coprime integers p and q greater than 1, in 1959, B proved that all sufficiently large integers can be expressed as a sum of pairwise terms of the form p^aq^b. As Davenport observed, Birch＇s proof can be modified that the exponent b can be bounded in terms of p and q. In 2000, N. Hegyvari effective version of this bound. The author improves this bound.展开更多
文摘Dear Editor, Many forms of sight-threatening diseases, including retinitis pigmentosa (RP) and age-related macular degeneration (AMD), are caused by the dysfunction, degeneration and loss of the retinal pigment epithelium (RPE)(Strauss, 2005). RPE cell transplantation may potentially recover or halt disease progression, in which human embryonic stem cells (hESCs) could serve as an unlimited donor source for RPE differentiation, and a few clinical trials have shown the safety and effective of transplantation of hESCs-derived RPE (hESC-RPE) for AMD patients (Schwartz et al., 2012;Schwartz etal., 2015;Song etal., 2015;da Cruz et al., 2018;Kashani et al., 2018;Liu et al., 2018).
基金Project supported by the National Natural Science Foundation of China (Nos. 10771103, 11071121)
文摘For any given coprime integers p and q greater than 1, in 1959, B proved that all sufficiently large integers can be expressed as a sum of pairwise terms of the form p^aq^b. As Davenport observed, Birch＇s proof can be modified that the exponent b can be bounded in terms of p and q. In 2000, N. Hegyvari effective version of this bound. The author improves this bound.
