Circular RNAs in breast cancer diagnosis,treatment and prognosis

Breast cancer has surpassed lung cancer to become the most common malignancy worldwide.The incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public health.Circular RNAs(circRNAs),a new class of noncoding RNAs(ncRNAs),have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression.In breast cancer,circRNAs have significant roles in tumorigenesis,recurrence and multidrug resistance that are mediated by various mechanisms.Therefore,circRNAs may serve as promising targets of therapeutic strategies for breast cancer management.This study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis,treatment and prognosis evaluation,as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast cancer.Understanding the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment.

“新工科”背景下科教融合实验教学——以MnO_(2)催化氧化VOCs实验为例

科教融合教学模式是“新工科”建设条件下高校教师将科研项目与教学紧密结合的必然选择。将“采用多种方法制备MnO_(2)催化剂并用于催化氧化VOCs的研究”引入到本科教学实验中。该实验设置了“文献调研→分组讨论→催化剂制备→活性评价及材料表征→实验数据分析与讨论→科研报告展现”等实验步骤,不仅加强了学生对理论知识的掌握,还培养了学生的动手实践能力和创新能力。通过科教融合的教学理念,力图达到培养具有良好团队合作精神和创新意识的高级应用技术型人才的目标。

增值税改革对制造业企业服务化的影响研究--基于“营改增”政策的准自然实验

“营改增”作为增值税改革的重要内容,其政策效应不仅限于减税,更重要的是促进制造业转型升级。本文利用2009~2018年我国制造业上市公司数据,采用双重差分法,以“营改增”政策作为准自然实验,考察增值税改革对制造业服务化的影响。并在此基础上,采用分组回归的方式考察增值税改革对企业服务化水平的差异性影响。研究表明:(1)增值税改革能够通过增加优质服务要素投入等四个方面提升制造业企业的服务化水平;(2)增值税改革对所有制、生命周期、企业所处地区市场化程度以及与服务业的关联程度不同的企业在服务化水平改变上存在差异。增值税改革对制造业企业服务化水平的促进作用在非国有企业、衰退期企业、高市场化地区的企业以及与服务业关联程度大的企业更明显。

A hydrothermal investigation system for the Qianlong-Ⅱ autonomous underwater vehicle

Qianlong-Ⅱ is a fully autonomous underwater vehicle designed for the investigation of submarine resources,particularly polymetallic sulfides. It was used to successfully explore hydrothermal fields on the Southwest Indian Ridge. Here, we summarized the exploration of hydrothermal systems using Qianlong-Ⅱ, including detailed descriptions of its implementation along with the systems used for data management and fast mapping. We also introduced a method to remove platform magnetic interference using magnetic data while Qianlong-Ⅱ is spinning. Based on hydrothermal anomalies collected by Qianlong-Ⅱ, we developed a rapid method for locating hydrothermal vents. Taking one dive as an example, we systemically demonstrated the process for analyzing hydrothermal survey data to locate hydrothermal vents.

Electrochemical Proton Storage:From Fundamental Understanding to Materials to Devices

Simultaneously improving the energy density and power density of electrochemical energy storage systems is the ultimate goal of electrochemical energy storage technology.An effective strategy to achieve this goal is to take advantage of the high capacity and rapid kinetics of electrochemical proton storage to break through the power limit of batteries and the energy limit of capacitors.This article aims to review the research progress on the physicochemical properties,electrochemical performance,and reaction mechanisms of electrode materials for electrochemical proton storage.According to the different charge storage mechanisms,the surface redox,intercalation,and conversion materials are classified and introduced in detail,where the influence of crystal water and other nanostructures on the migration kinetics of protons is clarified.Several reported advanced full cell devices are summarized to promote the commercialization of electrochemical proton storage.Finally,this review provides a framework for research directions of charge storage mechanism,basic principles of material structure design,construction strategies of full cell device,and goals of practical application for electrochemical proton storage.

The expression of chemokine MCP-1 in colorectal carcinoma and its relationship to the infiltration of macrophage

Objective: To study the expression of MCP-1 in colorectal carcinoma and its relationship to the infiltration of the macrophage and to the biological behaviour of infiltration and metastasis of colorectal carcinoma. Methods: The expression of the MCP-1 mRNA was assessed in colorectal carcinoma collected freshly from surgical specimen by RT-PCR and the expres- sion of the MCP-1 protein was assessed in colorectal carcinoma collected from surgical specimen by immunohistochemistry. The tumor infiltrating cell and macrophage were also investigated by immunohistochemistry. Results: All the 12 specimens of colorectal carcinoma detected by RT-PCR expressed the MCP-1 mRNA; MCP-1 protein was detected in 90℅ (36/40) cases of the tumor; The expression of the MCP-1 protein in colorectal carcinoma correlated negatively with its state of metastasis and the Dukes’ stage. But a postive correlation was found between the expression of MCP-1 and the infiltrated macrophage. The stron- ger expression of MCP-1, the more number of the infiltrated macrophage. Conclusion: The expression of chemokine MCP-1 in colorectal carcinoma may influence its biological behaviour of infiltration and metastasis, and can attract the immuno-cell to the local of the tumor, such as Macrophage.

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC patients.EGFR is crucial for promoting tumor metastasis and associated with poor prognosis.Therefore,it is vital to identify effective therapeutic strategies targeting EGFR inhibition.Ononin,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several cancers.In the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular pathways.We used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this objective.The results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC cells.These effects were achieved through the direct suppression of cell adhesion,invasiveness and motility.Furthermore,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung metastasis.Additionally,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot analysis.Furthermore,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or inhibitors.Importantly,ononin treatment did not exert any toxic effects on liver or kidney function.In conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRmediated PI3K/Akt/m TOR pathway.Further studies are warranted to validate its efficacy and explore its potential clinical applications.

A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain uncommon.What is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

A survey of immersive visualization:Focus on perception and interaction

Immersive visualization utilizes virtual reality,mixed reality devices,and other interactive devices to create a novel visual environment that integrates multimodal perception and interaction.This technology has been maturing in recent years and has found broad applications in various fields.Based on the latest research advancements in visualization,this paper summarizes the state-of-theart work in immersive visualization from the perspectives of multimodal perception and interaction in immersive environments,additionally discusses the current hardware foundations of immersive setups.By examining the design patterns and research approaches of previous immersive methods,the paper reveals the design factors for multimodal perception and interaction in current immersive environments.Furthermore,the challenges and development trends of immersive multimodal perception and interaction techniques are discussed,and potential areas of growth in immersive visualization design directions are explored.

零价铁去除水中(类)金属(含氧)离子技术发展的黄金十年(2011-2021)

应用零价铁(ZVI)去除水中(类)金属(含氧)离子是近年来研究的热点。在ZVI除污染过程中,同步提升ZVI除污的反应活性与电子效率对该技术进一步推广应用至关重要。本文综述了近十年(2011-2021年)ZVI的提升技术,主要涉及硫化、外加弱磁场、投加Fe^(2+)、投加氧化剂以及其他新型技术。从不同体系广谱研究以及单一体系具体研究的角度,系统分析了这些技术对ZVI去除含氧水体中(类)金属(含氧)离子的反应活性、去除容量、电子效率的提升表现及作用机制。最后,对ZVI技术未来的研究方向作出了展望,以期促进ZVI技术的进一步完善与发展。本文有望为增强零价铁去除污染物的实际效能提供新的探索方向并完备相关理论基础。

Activity and hydrothermal stability of CeO_2–ZrO_2–WO_3 for the selective catalytic reduction of NO_x with NH_3

A series of CeO2–ZrO2–WO3（CZW）catalysts prepared by a hydrothermal synthesis method showed excellent catalytic activity for selective catalytic reduction（SCR）of NO with NH3 over a wide temperature of 150–550℃.The effect of hydrothermal treatment of CZW catalysts on SCR activity was investigated in the presence of 10% H2O.The fresh catalyst showed above 90% NOx conversion at 201–459℃,which is applicable to diesel exhaust NOx purification（200–440℃）.The SCR activity results indicated that hydrothermal aging decreased the SCR activity of CZW at low temperatures（below 300℃）,while the activity was notably enhanced at high temperature（above 450℃）.The aged CZW catalyst（hydrothermal aging at 700℃ for 8 hr）showed almost 80% NOx conversion at 229–550℃,while the V2O5–WO3/TiO2 catalyst presented above 80% NOx conversion at 308–370℃.The effect of structural changes,acidity,and redox properties of CZW on the SCR activity was investigated.The results indicated that the excellent hydrothermal stability of CZW was mainly due to the CeO2–ZrO2 solid solution,amorphous WO3 phase and optimal acidity.In addition,the formation of WO3 clusters increased in size as the hydrothermal aging temperature increased,resulting in the collapse of structure,which could further affect the acidity and redox properties.

Effects of slurry viscosity and particle additive size on filter cake formation in highly permeable sand

Filter cake is critical to maintaining the stability of the excavation face of an underwater shield tunnel in a high-permeability stratum.In a high-permeability formation,generating an effective filter cake on the excavation face is difficult with a pure bentonite slurry,which penetrates the ground and may not achieve the required suspension pressure.Determining how to efficiently and quickly form a thin and low-permeability filter cake on the tunnel working face has become a key engineering problem in the construction of slurry shield tunnels in high-permeability strata.In this study,the relationship between slurry viscosity and the slurry pressure gradient of pure bentonite was established by performing slurry permeability experiments.The influence of slurry viscosity on the formation of the filter cake in a high-permeability formation was studied under different pressure gradients.In addition,the effect of additive particle size on the slurry filter cake formation was analyzed by introducing additives with different particle sizes to pure bentonite slurries with different viscosities.The test results indicate that(1)for the pure bentonite slurry,the critical initial pressure gradient can be used as a rough indicator of the formation of the filter cake,and the relationship between the critical maximum pore diameter and the average pore diameter of the for-mation can be compared to establish and analyze the formation law of the slurry filter cake;(2)adding particles to the slurry can enhance the effect of the pure bentonite slurry;and(3)adding coarse-grained materials can effectively improve the film-forming effect.The slurry is more compact when the particle size is close to the average pore size of the formation.

Application of fuzzy analytic hierarchy process model on determination of optimized pile-type

Pile-type selection is a very important stage of foundation design,and there are many field factors influencing the decision of pile-type selection.Since there is a limitation of traditional"major factors method"to satisfy the requirement of modem foundation construction,this study presents an efficient approach,in which analytic hierarchy process(AHP)is employed.AHP is a multiple criteria decision-making tool that has been applied in many fields related to the decision-making,e.g.,in the field of economics,marketing,sociology,etc.However,it is rarely reported that AHP is applied in the field of civil engineering for decision making.In this study,AHP combined with fuzzy synthetic evaluation method is employed to select the type of pile used as the foundation of a residential building in Fuzhou,Fujian Province,China.The results show that fuzzy AHP approach is an easy and efficient way for pile-type selection.

北京砖雕的传承脉络和现状

北京砖雕,承载着深厚的地域建筑文化底蕴,展现着北京民间传统雕刻工艺和京城传统建筑营造技艺的精髓。21世纪初,国家实施非物质文化遗产保护制度,北京砖雕项目在2005年列入北京西城区级非物质文化遗产保护名录,2007年列入北京市级非物质文化遗产保护名录。为北京砖雕在当代的传承与发展带来了新的生机,北京砖雕新时代的复兴、保护和北京砖雕技艺的传承群体发展成为当今人们关注的重点,本文以北京砖雕传承脉络和现状为主要研究对象,通过多年的田野调查、文献考证和口述史,着重讨论北京砖雕技艺传承群体在当前环境下的传承和发展具有重要社会意义。