Sirius Scheimpflug-Placido versus. ultrasound pachymetry for central corneal thickness: meta-analysis

Background:To compare the difference in central corneal thickness(CCT)measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer(Sirius,CSO,Italy)and ultrasound pachymetry(USP).Methods:A systematic literature search was conducted for relevant studies published on PubMed,Medline,EMBASE,and the Cochrane Library and ClinicalTrials.gov from inception to August 1st,2019.Primary outcome measures were CCT measurements between Sirius and USP.A random effects model was used to pool CCT measurements.Results:A total of twelve studies involving 862 eyes were included in this meta-analysis.The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different(P<0.0001).The mean difference between Sirius and USP was-11.26μm with a 95%confidence interval(CI)(-16.92μm,-5.60μm).The heterogeneity Was IP=60%(P=0.004).Conclusion:CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP.However,it may be argued that the mean difference of 11.26μm is not a clinically significant difference.

Sirius Scheimpflug–Placido versus ultrasound pachymetry for central corneal thickness:meta-analysis

Background:To compare the difference in central corneal thickness(CCT)measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer(Sirius,CSO,Italy)and ultrasound pachymetry(USP).Methods:A systematic literature search was conducted for relevant studies published on PubMed,Medline,EMBASE,and the Cochrane Library and ClinicalTrials.gov from inception to August 1st,2019.Primary outcome measures were CCT measurements between Sirius and USP.A random effects model was used to pool CCT measurements.Results:A total of twelve studies involving 862 eyes were included in this meta-analysis.The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different(P<0.0001).The mean difference between Sirius and USP was−11.26μm with a 95%confidence interval(CI)(−16.92μm,−5.60μm).The heterogeneity was I^(2)=60%(P=0.004).Conclusion:CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP.However,it may be argued that the mean difference of 11.26μm is not a clinically significant difference.

25G玻璃体切割联合IOL巩膜层间固定术的临床疗效

目的:评价25G玻璃体切割联合人工晶状体(IOL)巩膜层间固定术的临床疗效及安全性。方法:前瞻性临床研究。2014年10月至2016年12月期间在南京医科大学附属无锡第二医院临床检查确诊各种原因引起的晶状体脱位、IOL脱位、无晶状体眼且无后囊膜患者39例(39眼)纳入研究。采用25G玻璃体切割联合IOL巩膜层间固定术治疗。对比观察患者手术前后视力、眼压、角膜内皮细胞数量、IOL位置,以及术后IOL复位率、IOL脱位再发生率及并发症等情况,2个时间点之间的比较采用配对t检验,多个时间点之间的比较采用重复测量资料方差分析。结果:术后1周、1个月、3个月和6个月LogMAR视力较术前提高,各时间点间比较差异均有统计学意义(均P<0.05)。术后各时间点眼压较术前下降,各时间点间比较差异均有统计学意义(均P<0.05)。术后1周,所有患眼IOL均在位,位置居中。术后1个月,36眼(92%)IOL在位,位置居中;1眼(3%)IOL一袢暴露于结膜下;2眼(5%)IOL脱位。术后3~6个月,36眼IOL位置稳定。结论:25G玻璃体切割联合IOL巩膜层间固定术对无囊膜支撑的IOL植入具有良好的有效性及安全性。