ROS1 and EGFR are primary oncogenic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability o...ROS1 and EGFR are primary oncogenic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability of their co-occurrence. Consequently, clinical data and treatment strategies for their simultaneous presence are remarkably scarce. This report details the first recorded case of a sarcomatoid, poorly differentiated lung adenocarcinoma harboring both a ROS1 fusion and an EGFR mutation, alongside ARID1A and NFKBIA gene mutations. Moreover, this case study encompasses a review of instances featuring concurrent ROS1 and EGFR mutations. The identified genetic alterations in ROS1, EGFR, ARID1A, and NFKBIA are pivotal in the etiology of NSCLC. These mutations significantly influence disease progression and are essential for the development of personalized therapeutic approaches. Recognizing the unique genetic profiles in patients permits healthcare providers to devise customized treatment regimens that target these specific mutations, thereby enhancing patient outcomes in NSCLC.展开更多
Squealer tip is widely used in turbines to reduce tip leakage loss.In typical turbine environment,the squealer tip leakage flow is affected by multiple factors such as the relative casing motion and the wide range of ...Squealer tip is widely used in turbines to reduce tip leakage loss.In typical turbine environment,the squealer tip leakage flow is affected by multiple factors such as the relative casing motion and the wide range of variable incidence angles.The development of experimental methods which can accurately model the real turbine environment and influencing factors is of great significance to study the squealer tip leakage flow mechanism.In the present paper,a low-speed turbine cascade test facility which can model the relative casing motion and wide range of variable incidence angles(-25°to 55°)is built.Based on the similarity criteria,a high-low speed similarity transformation method of the turbine cascade is established by considering the thickness of the turbine blade.A combined testing method of Particle Image Velocimetry(PIV)and local pressure measurement is proposed to obtain the complex flow structures within the tip cavity.The results show that the experimental method can successfully model the relative casing motion and the wide range of variable incidence angles.The low-speed cascade obtained by the similarity transformation can model the high-speed flow accurately.The measurement technique developed can obtain the complex flow field and successfully capture the scraping vortex within the squealer tip.展开更多
文摘ROS1 and EGFR are primary oncogenic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability of their co-occurrence. Consequently, clinical data and treatment strategies for their simultaneous presence are remarkably scarce. This report details the first recorded case of a sarcomatoid, poorly differentiated lung adenocarcinoma harboring both a ROS1 fusion and an EGFR mutation, alongside ARID1A and NFKBIA gene mutations. Moreover, this case study encompasses a review of instances featuring concurrent ROS1 and EGFR mutations. The identified genetic alterations in ROS1, EGFR, ARID1A, and NFKBIA are pivotal in the etiology of NSCLC. These mutations significantly influence disease progression and are essential for the development of personalized therapeutic approaches. Recognizing the unique genetic profiles in patients permits healthcare providers to devise customized treatment regimens that target these specific mutations, thereby enhancing patient outcomes in NSCLC.
基金supported by the National Natural Science Foundation of China(No.51676005)。
文摘Squealer tip is widely used in turbines to reduce tip leakage loss.In typical turbine environment,the squealer tip leakage flow is affected by multiple factors such as the relative casing motion and the wide range of variable incidence angles.The development of experimental methods which can accurately model the real turbine environment and influencing factors is of great significance to study the squealer tip leakage flow mechanism.In the present paper,a low-speed turbine cascade test facility which can model the relative casing motion and wide range of variable incidence angles(-25°to 55°)is built.Based on the similarity criteria,a high-low speed similarity transformation method of the turbine cascade is established by considering the thickness of the turbine blade.A combined testing method of Particle Image Velocimetry(PIV)and local pressure measurement is proposed to obtain the complex flow structures within the tip cavity.The results show that the experimental method can successfully model the relative casing motion and the wide range of variable incidence angles.The low-speed cascade obtained by the similarity transformation can model the high-speed flow accurately.The measurement technique developed can obtain the complex flow field and successfully capture the scraping vortex within the squealer tip.
