Voxel-based morphometry is gaining considerable interest for studies examining Parkinson＇s disease dementia patients. In this study, 12 patients with clinically defined Parkinson＇s disease and dementia and 12 non-de...Voxel-based morphometry is gaining considerable interest for studies examining Parkinson＇s disease dementia patients. In this study, 12 patients with clinically defined Parkinson＇s disease and dementia and 12 non-demented patients with Parkinson＇s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson＇s disease patients without dementia, decreased gray matter volume in Parkinson＇s disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.展开更多
基金supported by the Medical Clinical Science and Technology Development Fund of Jiangsu University,No.JLY20120122Innovative Climb Program of Natural Science Foundation of Jiangsu Province,No.BK2008010+1 种基金Natural Science Foundation of Nantong University,China,No.11Z001Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Voxel-based morphometry is gaining considerable interest for studies examining Parkinson＇s disease dementia patients. In this study, 12 patients with clinically defined Parkinson＇s disease and dementia and 12 non-demented patients with Parkinson＇s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson＇s disease patients without dementia, decreased gray matter volume in Parkinson＇s disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.
