Peng et al.[Science 379683(2023)]reported an effective method to improve the performance of perovskite solar cells by using thicker porous insulator contact(PIC)-alumina nanoplates.This method overcomes the trade-off ...Peng et al.[Science 379683(2023)]reported an effective method to improve the performance of perovskite solar cells by using thicker porous insulator contact(PIC)-alumina nanoplates.This method overcomes the trade-off between the open-circuit voltage and the fill factor through two mechanisms:reduced surface recombination velocity and increased bulk recombination lifetime due to better perovskite crystallinity.From arguments of drift-diffusion simulations,we find that an increase in mobility and carrier recombination lifetime in bulk are the key factors for minimizing the resistance-effect from thicker PICs and achieving a maximum power conversion efficiency(PCE)at approximately 25%reduced contact area.Furthermore,the partially replacement of perovskite films with thicker PICs would result in a reduction in short-current density,but the relative low refractive index of the PICs imbedded into the high refractive index perovskite creates light trapping structures that compensate for this loss.展开更多
The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanom...The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanomedicine. Herein, we propose a strategy where the anticancer peptide acts as water-soluble monomer to directly participate in emulsion interfacial polymerization for fabricating polypeptide nanospheres. The constructed polypeptide nanospheres hold a high drug loading efficiency of 77%, and can be stably dispersed in highly diluted aqueous solutions. The acid-labile amide linkage in polypeptide nanospheres can be hydrolyzed in tumor acidic environments, thus releasing anticancer peptides selectively. The polypeptide nanospheres achieve significantly enhanced anticancer activity against HCT116 cells in vitro and in vivo through improved mitochondrial and membrane disruption. In addition, its side effects on normal cells can be reduced significantly. It is highly anticipated that more kinds of anticancer drug candidates or anticancer drugs can be applied to fabricate polymeric nanomedicines with improved anticancer activity through this strategy.展开更多
Planktonic ciliates have been recognized as major consumers of nano-and picoplankton in pelagic ecosystems,playing pivotal roles in the transfer of matter and energy in the microbial loop.However,due to the difculties...Planktonic ciliates have been recognized as major consumers of nano-and picoplankton in pelagic ecosystems,playing pivotal roles in the transfer of matter and energy in the microbial loop.However,due to the difculties in identifcation,the species composition of ciliate assemblages,especially for the small,fragile,and naked species that usually dominate the ciliate communities in the oceanic waters,remains largely unknown.In the present study,22 stations along the transect from Shenzhen(China)to Pohnpei(Micronesia)were sampled for the enumeration of picoplankton and nanofagellates.In addition,pigment analysis of major phytoplankton groups along with the measurements of environmental variables including temperature,salinity,and nutrients were also carried out.Ciliates were identifed at species level using quantitative protargol stain to reveal the species composition and their distribution patterns from of-shore to open ocean.Ciliate abundance was positively correlated with phosphate,silicate,and pico-sized pigmented eukaryotes(PPEs),whereas the biomass was closely related with PPEs,heterotrophic nanofagellates,and chlorophytes.The combination of silicate and pigmented nanofagellates was identifed as the major factor driving the ciliate community composition.The close relationship between silicate and ciliate abundance and community structure needs further validation based on more data collected from oceanic waters.Our study showed the necessity of using techniques that can reveal the community composition at higher taxonomic resolutions in future studies on ciliates.展开更多
An Escherichia coli reduction-powered supramolecular polymerization is reported,leading to the fabrication of a near-infrared(NIR)photothermal antibacterial agent in situ.To this end,a bifunctional monomer containing ...An Escherichia coli reduction-powered supramolecular polymerization is reported,leading to the fabrication of a near-infrared(NIR)photothermal antibacterial agent in situ.To this end,a bifunctional monomer containing two viologen moieties was designed.WhenincubatingE.coli with thebifunctional monomer and cucurbit[8]uril,viologen moieties were reduced to viologen cation radicals by E.coli,and a supramolecular polymer with supramolecular dimers of viologen cation radicals integrated into the main chain was fabricated on the surface of E.coli.展开更多
基金Project supported by the Qing-Lan Project from Yangzhou Universitythe National Natural Science Foundation of China (Grant No. 62375234)
文摘Peng et al.[Science 379683(2023)]reported an effective method to improve the performance of perovskite solar cells by using thicker porous insulator contact(PIC)-alumina nanoplates.This method overcomes the trade-off between the open-circuit voltage and the fill factor through two mechanisms:reduced surface recombination velocity and increased bulk recombination lifetime due to better perovskite crystallinity.From arguments of drift-diffusion simulations,we find that an increase in mobility and carrier recombination lifetime in bulk are the key factors for minimizing the resistance-effect from thicker PICs and achieving a maximum power conversion efficiency(PCE)at approximately 25%reduced contact area.Furthermore,the partially replacement of perovskite films with thicker PICs would result in a reduction in short-current density,but the relative low refractive index of the PICs imbedded into the high refractive index perovskite creates light trapping structures that compensate for this loss.
基金financially supported by the Ministry of Science and Technology of China(2021YFA1501600,2018YFA0208900)the National Natural Science Foundation of China(21821001)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB36000000)。
文摘The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanomedicine. Herein, we propose a strategy where the anticancer peptide acts as water-soluble monomer to directly participate in emulsion interfacial polymerization for fabricating polypeptide nanospheres. The constructed polypeptide nanospheres hold a high drug loading efficiency of 77%, and can be stably dispersed in highly diluted aqueous solutions. The acid-labile amide linkage in polypeptide nanospheres can be hydrolyzed in tumor acidic environments, thus releasing anticancer peptides selectively. The polypeptide nanospheres achieve significantly enhanced anticancer activity against HCT116 cells in vitro and in vivo through improved mitochondrial and membrane disruption. In addition, its side effects on normal cells can be reduced significantly. It is highly anticipated that more kinds of anticancer drug candidates or anticancer drugs can be applied to fabricate polymeric nanomedicines with improved anticancer activity through this strategy.
基金This work was funded by the National Natural Science Foundation of China(Nos.41876142,91751207,41606168,and 41861144018)the Senior User Project of RV KEXUE(No.KEXUE2019G08)+3 种基金funded by the Center for Ocean Mega-Science,Chinese Academy of Sciences and China Ocean Mineral Resources R&D Association(DY135-E2-1-04)JY was also funded by MEL Visiting Fellowship(MELRS1921)the Fundamental Research Funds for the Central Universities(20lgpy66)HH was supported by the Training Program of Innovation and Entrepreneurship for Undergraduate at Xiamen University(2018X0724)Special thanks are given to Prof.
文摘Planktonic ciliates have been recognized as major consumers of nano-and picoplankton in pelagic ecosystems,playing pivotal roles in the transfer of matter and energy in the microbial loop.However,due to the difculties in identifcation,the species composition of ciliate assemblages,especially for the small,fragile,and naked species that usually dominate the ciliate communities in the oceanic waters,remains largely unknown.In the present study,22 stations along the transect from Shenzhen(China)to Pohnpei(Micronesia)were sampled for the enumeration of picoplankton and nanofagellates.In addition,pigment analysis of major phytoplankton groups along with the measurements of environmental variables including temperature,salinity,and nutrients were also carried out.Ciliates were identifed at species level using quantitative protargol stain to reveal the species composition and their distribution patterns from of-shore to open ocean.Ciliate abundance was positively correlated with phosphate,silicate,and pico-sized pigmented eukaryotes(PPEs),whereas the biomass was closely related with PPEs,heterotrophic nanofagellates,and chlorophytes.The combination of silicate and pigmented nanofagellates was identifed as the major factor driving the ciliate community composition.The close relationship between silicate and ciliate abundance and community structure needs further validation based on more data collected from oceanic waters.Our study showed the necessity of using techniques that can reveal the community composition at higher taxonomic resolutions in future studies on ciliates.
基金supported by the National Natural Science Foundation of China(nos.21890730,21890731,21821001,and 22071132).P.Z.was supported by the National Natural Science Foundation of China(nos.21771103 and 21977047)the Natural Science Foundation of Jiangsu Province(nos.BK20200058 and BK20202004)Fundamental Research Funds for the Central Universities(grant no.14380205).
文摘An Escherichia coli reduction-powered supramolecular polymerization is reported,leading to the fabrication of a near-infrared(NIR)photothermal antibacterial agent in situ.To this end,a bifunctional monomer containing two viologen moieties was designed.WhenincubatingE.coli with thebifunctional monomer and cucurbit[8]uril,viologen moieties were reduced to viologen cation radicals by E.coli,and a supramolecular polymer with supramolecular dimers of viologen cation radicals integrated into the main chain was fabricated on the surface of E.coli.
