Methicillin-resistant Staphylococcus aureus(MRSA)is a common pathogen causing acquired infections.Antibiotics are routinely employed for bacterial infection treatment.Excessive antibiotic use for bacterial infections ...Methicillin-resistant Staphylococcus aureus(MRSA)is a common pathogen causing acquired infections.Antibiotics are routinely employed for bacterial infection treatment.Excessive antibiotic use for bacterial infections heightens resistance,and MRSA resistance is being prevalent[1].MRSA exhibits substantial resistance to conventional antibiotics,which is associated with its biofilm-forming capability.The bacterial biofilm serves as a barrier,restricting nutrient access and slowing internal metabolism,increasing antibiotic resistance.The bacterial biofilm forms a defensive layer,resisting antibiotic penetration while preventing nutrient entry,inducing a slow bacterial metabolism,and increasing bacterial resistance[2].Consequently,biofilm formation and the emergence of resistance to conventional antibiotics have become substantial challenges in the field of infectious diseases.The development of agents to remove biofilm barriers is urgently required because biofilms are extremely hazardous.展开更多
基金supported by the National Natural Science Foundation of China(No.82060806)the Guangxi Natural Science Foundation Project(No.2023GXNSFAA026461)+2 种基金the Interdisciplinary innovation research team for key technologies of traditional Chinese medicine,emerging biological materials,and intelligent equipment development(GZKJ2303)Graduate education innovation project of Guangxi University of Chinese Medicine(YCSZ2022008)the college student innovation and entrepreneurship training program of Guangxi University of Chinese Medicine(S202310600107,202310600241,S20221060053).
文摘Methicillin-resistant Staphylococcus aureus(MRSA)is a common pathogen causing acquired infections.Antibiotics are routinely employed for bacterial infection treatment.Excessive antibiotic use for bacterial infections heightens resistance,and MRSA resistance is being prevalent[1].MRSA exhibits substantial resistance to conventional antibiotics,which is associated with its biofilm-forming capability.The bacterial biofilm serves as a barrier,restricting nutrient access and slowing internal metabolism,increasing antibiotic resistance.The bacterial biofilm forms a defensive layer,resisting antibiotic penetration while preventing nutrient entry,inducing a slow bacterial metabolism,and increasing bacterial resistance[2].Consequently,biofilm formation and the emergence of resistance to conventional antibiotics have become substantial challenges in the field of infectious diseases.The development of agents to remove biofilm barriers is urgently required because biofilms are extremely hazardous.
