BACKGROUND: Evidence illustrates that androgen has a neuroprotective role. However, whether androgen also has the protective effect on hippocampal neurons during free radical mediated injury remains unclear. OBJECTIV...BACKGROUND: Evidence illustrates that androgen has a neuroprotective role. However, whether androgen also has the protective effect on hippocampal neurons during free radical mediated injury remains unclear. OBJECTIVE: To investigate the neuroprotective effect of androgen on hippocampal neurons during free radical damage. DESIGN, TIME AND SETTING: A controlled in vitro experiment was performed at the Department of Human Anatomy, Cell Culture Lab, and Neuroendocrinology Lab, Basic Medical School, Hebei Medical University from February to June 2009. MATERIALS: Testosterone was provided by Tianjin Jinyao Amino Acid Company, China. METHODS: Primary cultured neurons from 24 Sprague Dawley rats were randomly assigned into four groups: control, H202, testosterone, and testosterone (pre-added) plus H2O2 groups. MAIN OUTCOME MEASURES: The positive cell ratio of microtubule associated protein-Ⅱ and neuron specific enolase was determined by immunocytochemistry. Neuronal morphology was observed by hematoxylin-eosin staining and Nissl staining. Cell vitality and viability were determined using an inverted phase contrast microscope. The content of nitric oxide synthase, malondialdehyde, and superoxide dismutase were measured with a spectrophotometer. RESULTS: As compared with the control group, cell vitality and viability, and superoxide dismutase level were significantly decreased in the H202 group (P 〈 0.05), while nitric oxide synthase and malondialdehyde levels were significantly increased (P 〈 0.05). Neuronal vitality and viability as well as superoxide dismutase level in the testosterone plus H2O2 group were significantly greater than in the H2O2 group (P 〈 0.05), and nitric oxide synthase and malondialdehyde levels were significantly less than in the H2O2 group (P〈 0.05). CONCLUSION: Androgen partially reversed H2O2-induced neuronal damage and protected neurons.展开更多
Complex permittivity and electrical impedance have been measured along the c-axis in single crystals BaFe_2 As_2,which are the conductors known as the parent compound of 122-type iron superconductor. The resultant rel...Complex permittivity and electrical impedance have been measured along the c-axis in single crystals BaFe_2 As_2,which are the conductors known as the parent compound of 122-type iron superconductor. The resultant relative errors defined in the study indicate the existence of the transformation between complex permittivity and electrical impedance in the conductors, and these two physics quantities possibly reveal different aspects of the consistent superconductivityrelevant physics picture.展开更多
Coupled inductor is one appealing technology to improve transient response and reduce output decoupling significantly in interleaved multi-phase voltage regulators (VRs). One well known problem is that coupled inducto...Coupled inductor is one appealing technology to improve transient response and reduce output decoupling significantly in interleaved multi-phase voltage regulators (VRs). One well known problem is that coupled inductor winding structure causes PCB routing path longer than discrete inductor design. This paper investigates possible PCB routing schemes for coupled inductor and conducts a fair and quantitative comparison with discrete inductor in a server VR design. Simulation and measurement are also conducted to verify the analysis.展开更多
A multi-functional polymer film with high hydrophobicity and transparency was formed by simple casting of a polycarbonate solution onto a substrate having micro-scale roughness.The high hydrophobicity was heat-resista...A multi-functional polymer film with high hydrophobicity and transparency was formed by simple casting of a polycarbonate solution onto a substrate having micro-scale roughness.The high hydrophobicity was heat-resistant,which can be retained up to 390 ℃.The polymer film may have potentially wide-ranging applications in industry and high technology.展开更多
Erratum to:Protein Cell 2012,3(2):84-88 DOI 10.1007/s13238-012-2012-y Due to a typesetting error,(~3-7×10^(13)mol/L)in the fifth line of the“TUS-TER microarray”subsection on the right column of page 85 should b...Erratum to:Protein Cell 2012,3(2):84-88 DOI 10.1007/s13238-012-2012-y Due to a typesetting error,(~3-7×10^(13)mol/L)in the fifth line of the“TUS-TER microarray”subsection on the right column of page 85 should be(~3-7×10^(−13)mol/L).展开更多
Lead halide perovskite nanocrystals have recently demonstrated great potential as x-ray scintillators,yet they stll suffer toxicity issues,inferior light yield(LY)caused by severe self-absorption.Nontoxic bivalent eur...Lead halide perovskite nanocrystals have recently demonstrated great potential as x-ray scintillators,yet they stll suffer toxicity issues,inferior light yield(LY)caused by severe self-absorption.Nontoxic bivalent europium ions(Eu^(2+))with intrinsically efficient and self-absorption-free d-f transition are a prospective replacement for the toxic Pb^(2+).Here,we demonstrated solution-processed organic-inorganic hybrid halide BA_(10)Eul_(12)(BA denotes C_(4)H_(9)NH_(4)^(+))single crystals for the first time.展开更多
文摘BACKGROUND: Evidence illustrates that androgen has a neuroprotective role. However, whether androgen also has the protective effect on hippocampal neurons during free radical mediated injury remains unclear. OBJECTIVE: To investigate the neuroprotective effect of androgen on hippocampal neurons during free radical damage. DESIGN, TIME AND SETTING: A controlled in vitro experiment was performed at the Department of Human Anatomy, Cell Culture Lab, and Neuroendocrinology Lab, Basic Medical School, Hebei Medical University from February to June 2009. MATERIALS: Testosterone was provided by Tianjin Jinyao Amino Acid Company, China. METHODS: Primary cultured neurons from 24 Sprague Dawley rats were randomly assigned into four groups: control, H202, testosterone, and testosterone (pre-added) plus H2O2 groups. MAIN OUTCOME MEASURES: The positive cell ratio of microtubule associated protein-Ⅱ and neuron specific enolase was determined by immunocytochemistry. Neuronal morphology was observed by hematoxylin-eosin staining and Nissl staining. Cell vitality and viability were determined using an inverted phase contrast microscope. The content of nitric oxide synthase, malondialdehyde, and superoxide dismutase were measured with a spectrophotometer. RESULTS: As compared with the control group, cell vitality and viability, and superoxide dismutase level were significantly decreased in the H202 group (P 〈 0.05), while nitric oxide synthase and malondialdehyde levels were significantly increased (P 〈 0.05). Neuronal vitality and viability as well as superoxide dismutase level in the testosterone plus H2O2 group were significantly greater than in the H2O2 group (P 〈 0.05), and nitric oxide synthase and malondialdehyde levels were significantly less than in the H2O2 group (P〈 0.05). CONCLUSION: Androgen partially reversed H2O2-induced neuronal damage and protected neurons.
基金Project supported by the National Natural Science Foundation of China(Grant No.11004106)the National Basic Research Program of China(Grant No.2015CB946502)+1 种基金the Chinese Academy of Sciences(Grant No.SPRP-B:XDB25000000)the Youth Innovation Promotion Association of Chinese Academy of Sciences
文摘Complex permittivity and electrical impedance have been measured along the c-axis in single crystals BaFe_2 As_2,which are the conductors known as the parent compound of 122-type iron superconductor. The resultant relative errors defined in the study indicate the existence of the transformation between complex permittivity and electrical impedance in the conductors, and these two physics quantities possibly reveal different aspects of the consistent superconductivityrelevant physics picture.
文摘Coupled inductor is one appealing technology to improve transient response and reduce output decoupling significantly in interleaved multi-phase voltage regulators (VRs). One well known problem is that coupled inductor winding structure causes PCB routing path longer than discrete inductor design. This paper investigates possible PCB routing schemes for coupled inductor and conducts a fair and quantitative comparison with discrete inductor in a server VR design. Simulation and measurement are also conducted to verify the analysis.
基金the National Natural Science Foundation of China(grant no.21101010)the Innovation Foundation of BUAA for PhD Graduates(296181)for continuing financial support
文摘A multi-functional polymer film with high hydrophobicity and transparency was formed by simple casting of a polycarbonate solution onto a substrate having micro-scale roughness.The high hydrophobicity was heat-resistant,which can be retained up to 390 ℃.The polymer film may have potentially wide-ranging applications in industry and high technology.
文摘Erratum to:Protein Cell 2012,3(2):84-88 DOI 10.1007/s13238-012-2012-y Due to a typesetting error,(~3-7×10^(13)mol/L)in the fifth line of the“TUS-TER microarray”subsection on the right column of page 85 should be(~3-7×10^(−13)mol/L).
基金the National Key R&D Program of China(grant no.2021YFB3501800)the National Natural Science Foundation of China(62250003,61725401,62104077,62204092,62004076,and 62134003)+2 种基金the Postdoctoral Research Foundation of China(2022M710054)the Foundation for Innovative Research Groups of Hubei Province of China(2020CFA034)This research is also supported by the Open Project Program of Wuhan National Laboratory for Optoelectronics(no.2022WNLOKF004).
文摘Lead halide perovskite nanocrystals have recently demonstrated great potential as x-ray scintillators,yet they stll suffer toxicity issues,inferior light yield(LY)caused by severe self-absorption.Nontoxic bivalent europium ions(Eu^(2+))with intrinsically efficient and self-absorption-free d-f transition are a prospective replacement for the toxic Pb^(2+).Here,we demonstrated solution-processed organic-inorganic hybrid halide BA_(10)Eul_(12)(BA denotes C_(4)H_(9)NH_(4)^(+))single crystals for the first time.