To the Editor:In middle-aged and elderly individuals,intervertebral disc(IVD)degeneration(IVDD)can often cause low back pain(LBP).IVDD has a complex mechanism with many influencing factors.Biological changes in degene...To the Editor:In middle-aged and elderly individuals,intervertebral disc(IVD)degeneration(IVDD)can often cause low back pain(LBP).IVDD has a complex mechanism with many influencing factors.Biological changes in degenerative IVDs mainly include structural abnormalities of the nucleus pulposus(NP),annulus fibrosus(AF),and cartilage endplate,as well as changes in the composition and amount of extracellular matrix(ECM).IVDD disease is treated conservatively,followed by surgery,but these are symptomatic treatments.展开更多
文摘To the Editor:In middle-aged and elderly individuals,intervertebral disc(IVD)degeneration(IVDD)can often cause low back pain(LBP).IVDD has a complex mechanism with many influencing factors.Biological changes in degenerative IVDs mainly include structural abnormalities of the nucleus pulposus(NP),annulus fibrosus(AF),and cartilage endplate,as well as changes in the composition and amount of extracellular matrix(ECM).IVDD disease is treated conservatively,followed by surgery,but these are symptomatic treatments.
