Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early v...Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early vascular network has small scale.If we remove the tumor early and biopsy it,it will increase the spread of the cancer cells and infection and bleeding.In this case,we presented a new angiography method.A high-resolution OCT system for noninvasive an-giographic imaging of early skin melanoma-Swept Source Optical Coberence Tomography Angiography(SS-OCTA)is proposed.With a high lateral resolution of 10pm in vrivo tomographic angiography,SS-OCTA is used to image and identify the morphology of the early tumor blood vessels.In addition,a control group experiment is conducted to observe the growth of melanoma in the process of rupture,malormation of micro-vessels.The results of the analysis and statistical test(P<0.05)are statistically signifcant.展开更多
In order to evaluate the eco-toxicological effects of Roundup® on Carassius auratus (C. auratus), fish were exposed to 32 μg/L Roundup®, isopropylamine salt of glyphosate (G.I.S) and polyoxyethylene ami...In order to evaluate the eco-toxicological effects of Roundup® on Carassius auratus (C. auratus), fish were exposed to 32 μg/L Roundup®, isopropylamine salt of glyphosate (G.I.S) and polyoxyethylene amine (POEA) over different periods (0.5, 1, 3, 7 and 14 d). Hydroxyl radical (·OH), malondialdehyde (MDA) and acetylcholinesterase (AChE) in liver were detected in this study. Results showed that the generation of ·OH increased before 7 d, but without significantly difference. ·OH was induced at 1 d for POEA group, 3 d for Roundup® group and 7 d for G.I.S group. At 14 d, ·OH generation returned to normal levels. MDA contents all increased significantly (p < 0.01) during 7 days and then reached a normal level at 14 d. AChE activity in all group tests revealed a significant inhibition (p < 0.01) after 7 days exposure and then rebounded a little, but remained below the control after 14 days exposure. The rate of AChE inhibition range from 13% - 42% in Roundup®, 6% - 40% in G.I.S, and 21% - 54% in POEA, suggesting that POEA was more toxic compared to Roundup® and G.I.S. 32 μg/L Roundup® exposure led to the change of physiological and biochemical indexes in C. auratus, which was a reversible process in the long run.展开更多
基金supported by the Jiangsu Province Science Fund for Distinguished Young Scholars(BK20060010)the Frontier Science Research project of the Chinese Academy of Sciences(QYZDBS-SWJSC03)+2 种基金the National Natural Science Foundation of China(61675226)the National Key R&D Program of China(2017YFC0108200,2017YFB0403700)the Jiangsu Province Key R&D Program(BE2018667).
文摘Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early vascular network has small scale.If we remove the tumor early and biopsy it,it will increase the spread of the cancer cells and infection and bleeding.In this case,we presented a new angiography method.A high-resolution OCT system for noninvasive an-giographic imaging of early skin melanoma-Swept Source Optical Coberence Tomography Angiography(SS-OCTA)is proposed.With a high lateral resolution of 10pm in vrivo tomographic angiography,SS-OCTA is used to image and identify the morphology of the early tumor blood vessels.In addition,a control group experiment is conducted to observe the growth of melanoma in the process of rupture,malormation of micro-vessels.The results of the analysis and statistical test(P<0.05)are statistically signifcant.
基金The research was funded through the National Science Foundation of China(No.21077051,51278241)the Jiangsu Natural Science Foundation(No.BK2011057).
文摘In order to evaluate the eco-toxicological effects of Roundup® on Carassius auratus (C. auratus), fish were exposed to 32 μg/L Roundup®, isopropylamine salt of glyphosate (G.I.S) and polyoxyethylene amine (POEA) over different periods (0.5, 1, 3, 7 and 14 d). Hydroxyl radical (·OH), malondialdehyde (MDA) and acetylcholinesterase (AChE) in liver were detected in this study. Results showed that the generation of ·OH increased before 7 d, but without significantly difference. ·OH was induced at 1 d for POEA group, 3 d for Roundup® group and 7 d for G.I.S group. At 14 d, ·OH generation returned to normal levels. MDA contents all increased significantly (p < 0.01) during 7 days and then reached a normal level at 14 d. AChE activity in all group tests revealed a significant inhibition (p < 0.01) after 7 days exposure and then rebounded a little, but remained below the control after 14 days exposure. The rate of AChE inhibition range from 13% - 42% in Roundup®, 6% - 40% in G.I.S, and 21% - 54% in POEA, suggesting that POEA was more toxic compared to Roundup® and G.I.S. 32 μg/L Roundup® exposure led to the change of physiological and biochemical indexes in C. auratus, which was a reversible process in the long run.
