SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how S...SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.展开更多
Recently,Nature and Nature Cell Biology published five papers on the function and molecular mechanism of ADAR1(adenosine deaminases acting on RNA)in aging,cancer,and autoimmune diseases.1,2,3,4,5 Among them,four paper...Recently,Nature and Nature Cell Biology published five papers on the function and molecular mechanism of ADAR1(adenosine deaminases acting on RNA)in aging,cancer,and autoimmune diseases.1,2,3,4,5 Among them,four papers published in Nature revealed that ADAR1 regulates autoimmune disease and cancer immunotherapy through canonical adenosine-to-inosine(A-to-I)RNA editing.展开更多
基金supported by grants from The National Natural Science Foundation of China(No.81971132,82271306)the Sichuan Science and Technology Program(China)(No.2021ZYD0106,2021ZYD0091,22ZDYF3783,2022YFS0615,2023YFH0069,2023NSFSC0028,2023NSFSC1559)+1 种基金Project of Luzhou Science and Technology Bureau(No.2021LZXNYDP01,2021LZXNYD-Z05)Luzhou Government-Southwest Medical University Strategic Cooperation Project and Southwest Medical University Project(Sichuan,China)(No.2021ZKQN058,2020ZRQNB072,2021ZKZD013,2021ZKQN041).
文摘SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.
基金We would like to thank Dr.Changchang Chao and Dr.Juan Chen for their help and support.This work was supported by the National Natural Science Foundation of China(32130064,32025008,91940306,and 81921003)the National Key Research and Development Program of China(2022YFA1303300)+1 种基金the Strategic Priority Program of CAS(XDB37000000)the K.C.Wong Education Foundation(GJTD-2020-06)to Y.X.
文摘Recently,Nature and Nature Cell Biology published five papers on the function and molecular mechanism of ADAR1(adenosine deaminases acting on RNA)in aging,cancer,and autoimmune diseases.1,2,3,4,5 Among them,four papers published in Nature revealed that ADAR1 regulates autoimmune disease and cancer immunotherapy through canonical adenosine-to-inosine(A-to-I)RNA editing.
